Search Results - "Latus, L J"

The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity by Bom, D., Curran, D.P., Zhang, J., Zimmer, S.G., Bevins, R., Kruszewski, S., Howe, J.N., Bingcang, A., Latus, L.J., Burke, T.G.

“…The novel silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67) is 25- to 50-times more lipophilic than camptothecin and readily incorporates into…”
Get full text

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity by Bom, David, Curran, Dennis P, Kruszewski, Stefan, Zimmer, Stephen G, Thompson Strode, J, Kohlhagen, Glenda, Du, Wu, Chavan, Ashok J, Fraley, Kimberly A, Bingcang, Alex L, Latus, Lori J, Pommier, Yves, Burke, Thomas G

“…We describe the rational design and synthesis of B- and A,B-ring-modified camptothecins. The key α-hydroxy-δ-lactone pharmacophore in…”
Get full text

Specific Alterations of U1-C Protein or U1 Small Nuclear RNA Can Eliminate the Requirement of Prp28p, an Essential DEAD Box Splicing Factor by Chen, Jeff Yi-Fu, Stands, Leah, Staley, Jonathan P, Jackups, Ronald R, Latus, Lori J, Chang, Tien-Hsien

“…While some members of the ubiquitous DExD/H box family of proteins have RNA helicase activity in vitro, their roles in vivo remain virtually unknown. Here, we…”
Get full text

Effects of platelet-contained growth factors (PDGF, EGF, IGF-I, and TGF-beta) on DNA synthesis in porcine aortic smooth muscle cells in culture by Hwang, D L, Latus, L J, Lev-Ran, A

“…Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and transforming growth factor-beta (TGF-beta) are…”
Get more information

Genetic Interactions of Conserved Regions in the DEAD-Box Protein Prp28p by Chang, Tien-Hsien, Latus, Lori J., Liu, Zheng, Abbott, John M.

“…The yeast PRP28 gene has been implicated in nuclear precursor messenger RNA (pre-mRNA) splicing, a two-step reaction involved in a multitude of RNA structural…”
Get full text

The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction by De Meyts, P, Wallach, B, Christoffersen, C T, Ursø, B, Grønskov, K, Latus, L J, Yakushiji, F, Ilondo, M M, Shymko, R M

“…The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our…”
Get more information

Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection by Zhang, Junhong, Burke, Thomas G, Latus, Lori J

“…A novel insoluble topoisomerase I inhibitor, 9-nitrocamptothecin (9-NC), is in advanced stages of clinical development and has been used to treat a diverse…”
Get full text