Search Results - "Lattmann, Rene"

Development of tridentate iron chelators: from desferrithiocin to ICL670 by Nick, Hanspeter, Acklin, Pierre, Lattmann, René, Buehlmayer, Peter, Hauffe, Suzanne, Schupp, Joachim, Alberti, Daniele

“…Successful treatment of beta-thalassemia requires two key elements: blood transfusion and iron chelation. Regular blood transfusions considerably expand the…”
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Decomposing the effects of α-tACS on brain oscillations and aperiodic 1/f activity by Kasten, Florian H., Lattmann, René, Strüber, Daniel, Herrmann, Christoph S.

“…•Effects of tACS are decomposed onto periodic and aperiodic activity.•Removing 1/f brain activity does not change the effect of tACS on α-oscillations.•1/f…”
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Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension by Shaw, Duncan E., Smith, Nichola, Beerli, Rene, Cotesta, Simona, D’Alessandro, Pier-Luca, Edwards, Anne-Marie, Lattmann, Rene, Lizos, Dimitrios, Pulz, Robert, Rooney, Lisa, Sohal, Bindi, Rynn, Caroline, Taylor, Jessica, Troxler, Thomas, Williams, Gareth, Guth, Sabine, Rowlands, David

“…Pulmonary arterial hypertension (PAH) is a devastating rare disease, which despite currently available treatments, still represents a high unmet medical need…”
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2-Cyano-pyrimidines:  A New Chemotype for Inhibitors of the Cysteine Protease Cathepsin K by Altmann, Eva, Aichholz, Reiner, Betschart, Claudia, Buhl, Thomas, Green, Jonathan, Irie, Osamu, Teno, Naoki, Lattmann, René, Tintelnot-Blomley, Marina, Missbach, Martin

“…Starting from the purine lead structure 1, a new series of cathepsin K inhibitors based on a pyrimidine scaffold have been explored. Investigations of P3 and…”
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Novel scaffold for cathepsin K inhibitors by Teno, Naoki, Miyake, Takahiro, Ehara, Takeru, Irie, Osamu, Sakaki, Junichi, Ohmori, Osamu, Gunji, Hiroki, Matsuura, Naoko, Masuya, Keiichi, Hitomi, Yuko, Nonomura, Kazuhiko, Horiuchi, Miyuki, Gohda, Keigo, Iwasaki, Atsuko, Umemura, Ichiro, Tada, Sachiyo, Kometani, Motohiko, Iwasaki, Genji, Cowan-Jacob, Sandra W., Missbach, Martin, Lattmann, René, Betschart, Claudia

“…Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3…”
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Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism by Kallen, Joerg, Lattmann, Rene, Beerli, Rene, Blechschmidt, Anke, Blommers, Marcel J.J., Geiser, Martin, Ottl, Johannes, Schlaeppi, Jean-Marc, Strauss, Andre, Fournier, Brigitte

“…Inverse agonists of the constitutively active human estrogen-related receptorα (ERRα, NR3B1) are of potential interest for several disease indications (e.g…”
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Dipeptide nitrile inhibitors of cathepsin K by Altmann, Eva, Aichholz, Reiner, Betschart, Claudia, Buhl, Thomas, Green, Jonathan, Lattmann, René, Missbach, Martin

“…A series of dipeptidyl nitriles as inhibitors of cathepsin K have been explored starting from lead structure 1 (Cbz–Leu–NH–CH 2–CN, IC 50 = 39 nM). Attachment…”
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Preparation of 10,11-Epoxy-carbamazepine and 10,11-Dihydro-10-hydroxy-carbamazepine by Microbial Epoxidation and Hydroxylation by Kittelmann, Matthias, Lattmann, Rene, Ghisalba, Oreste

“…Within a microbial screening two bacterial strains were identified that epoxidize carbamazepine (CBZ) to 10,11-epoxy-CBZ. Ten strains could hydroxylate…”
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4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]- benzoic Acid: A Novel Efficient and Selective Iron(III) Complexing Agent by Heinz, Uwe, Hegetschweiler, Kaspar, Acklin, Pierre, Faller, Bernard, Lattmann, René, Schnebli, Hans Peter

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Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism by Joerg Kallen, Rene Lattmann, Rene Beerli, Anke Blechschmidt, Marcel J. J. Blommers, Martin Geiser, Johannes Ottl, Jean-Marc Schlaeppi, Andre Strauss, Brigitte Fournier

“…Inverse agonists of the constitutively active human estrogen-related receptorα (ERRα, NR3B1) are of potential interest for several disease indications ( e.g…”
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ICL670A: preclinical profile by Nick, Hanspeter, Wong, Agnes, Acklin, Pierre, Faller, Bernard, Jin, Yi, Lattmann, René, Sergejew, Thomas, Hauffe, Suzanne, Thomas, Helmut, Schnebli, Hans Peter

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4‐[3,5‐Bis(2‐hydroxyphenyl)‐1,2,4‐triazol‐1‐yl]‐ benzoic Acid: A Novel Efficient and Selective Iron(III) Complexing Agent by Heinz, Uwe, Hegetschweiler, Kaspar, Acklin, Pierre, Faller, Bernard, Lattmann, René, Schnebli, Hans Peter

“…An exceptionally stable 1:2 complex [FeL2]3− is formed from the ligand H3L and FeIII. In contrast, the affinity of this ligand for other biometals is…”
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4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoesäure: ein neuartiger, effizienter und selektiver Eisen(III)-Komplexbildner by Heinz, Uwe, Hegetschweiler, Kaspar, Acklin, Pierre, Faller, Bernard, Lattmann, René, Schnebli, Hans Peter

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4‐[3,5‐Bis(2‐hydroxyphenyl)‐1,2,4‐triazol‐1‐yl]benzoesäure: ein neuartiger, effizienter und selektiver Eisen(III)‐Komplexbildner by Heinz, Uwe, Hegetschweiler, Kaspar, Acklin, Pierre, Faller, Bernard, Lattmann, René, Schnebli, Hans Peter

“…Einen außerordentlich stabilen 1:2‐Komplex [FeL2]3− bildet der Ligand H3L (siehe Formel) mit FeIII. Seine Affinität für andere Biometalle ist dagegen…”
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D-Ribulokinase from Klebsiella pneumoniae for continuous production of D-(-)-ribulose-5-phosphate by GYGAX, D, NACHTEGAAL, H, GHISALBA, O, LATTMANN, R, SCHAÊR, H.-P, WANDREY, C, STREIFF, M. B

“…The production of D-ribulose-5-phosphate in an enzyme membrane reactor was examined. Phosphoryl transfer from ATP to D-ribulose was catalysed by D-ribulokinase…”
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