Search Results - "Lattime, Edmund C."

Targeting tumor-associated macrophages to combat pancreatic cancer by Cui, Ran, Yue, Wen, Lattime, Edmund C, Stein, Mark N, Xu, Qing, Tan, Xiang-Lin

“…The tumor microenvironment is replete with cells that evolve with and provide support to tumor cells during the transition to malignancy. The hijacking of the…”
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Early Detection of Myeloid-Derived Suppressor Cells in the Lung Pre-Metastatic Niche by Shortwave Infrared Nanoprobes by Siebert, Jake N, Shah, Jay V, Tan, Mei Chee, Riman, Richard E, Pierce, Mark C, Lattime, Edmund C, Ganapathy, Vidya, Moghe, Prabhas V

“…Metastatic breast cancer remains a significant source of mortality amongst breast cancer patients and is generally considered incurable in part due to the…”
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Shortwave‐Infrared‐Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer by Shah, Jay V., Siebert, Jake N., Zhao, Xinyu, He, Shuqing, Riman, Richard E., Tan, Mei Chee, Pierce, Mark C., Lattime, Edmund C., Ganapathy, Vidya, Moghe, Prabhas V.

“…Checkpoint immunotherapy has made great strides in the treatment of solid tumors, but many patients do not respond to immune checkpoint inhibitors…”
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Integrated metabolic and genetic analysis reveals distinct features of human differentiated thyroid cancer by Cararo Lopes, Eduardo, Sawant, Akshada, Moore, Dirk, Ke, Hua, Shi, Fuqian, Laddha, Saurabh, Chen, Ying, Sharma, Anchal, Naumann, Jake, Guo, Jessie Yanxiang, Gomez, Maria, Ibrahim, Maria, Smith, Tracey L., Riedlinger, Gregory M., Lattime, Edmund C., Trooskin, Stanley, Ganesan, Shridar, Su, Xiaoyang, Pasqualini, Renata, Arap, Wadih, De, Subhajyoti, Chan, Chang S., White, Eileen

“…Background Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with a good prognosis…”
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Recombinant Poxvirus and the Tumor Microenvironment: Oncolysis, Immune Regulation and Immunization by Sharp, Daniel W, Lattime, Edmund C

“…Oncolytic viruses (OVs) are being extensively studied for their potential roles in the development of cancer therapy regimens. In addition to their direct…”
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Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death by Kohlhapp, Frederick J., Huelsmann, Erica J., Lacek, Andrew T., Schenkel, Jason M., Lusciks, Jevgenijs, Broucek, Joseph R., Goldufsky, Josef W., Hughes, Tasha, Zayas, Janet P., Dolubizno, Hubert, Sowell, Ryan T., Kühner, Regina, Burd, Sarah, Kubasiak, John C., Nabatiyan, Arman, Marshall, Sh’Rae, Bommareddy, Praveen K., Li, Shengguo, Newman, Jenna H., Monken, Claude E., Shafikhani, Sasha H., Marzo, Amanda L., Guevara-Patino, Jose A., Lasfar, Ahmed, Thomas, Paul G., Lattime, Edmund C., Kaufman, Howard L., Zloza, Andrew

“…In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune…”
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Autophagy Regulates Stress Responses, Metabolism, and Anticancer Immunity by White, Eileen, Lattime, Edmund C, Guo, Jessie Yanxiang

“…Autophagy is a catabolic intracellular nutrient-scavenging pathway triggered by nutrient deprivation and stress that captures and degrades intracellular…”
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Vaccinia virus leads to ATG12-ATG3 conjugation and deficiency in autophagosome formation by Moloughney, Joseph G., Monken, Claude E., Tao, Hanlin, Zhang, Haiyan, Thomas, Janice D., Lattime, Edmund C., Jin, Shengkan V.

“…The interactions between viruses and cellular autophagy have been widely reported. On the one hand, autophagy is an important innate immune response against…”
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Bacillus Calmette-Guerin mechanism of action: the role of immunity, apoptosis, necrosis and autophagy by DiPaola, Robert S, Lattime, Edmund C

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Cellular Autophagy Machinery is not Required for Vaccinia Virus Replication and Maturation by Zhang, Haiyan, Monken, Claude E., Lenard, John, Mizushima, Noboru, Lattime, Edmund C., Jin, Shengkan

“…The origin of the primary membrane of vaccinia virus, the double-membrane structure that surrounds the immature virions (IV), is not fully understood. Here we…”
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Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain by Staquicini, Daniela I., Tang, Fenny H. F., Markosian, Christopher, Yao, Virginia J., Staquicini, Fernanda I., Dodero-Rojas, Esteban, Contessoto, Vinícius G., Davis, Deodate, O’Brien, Paul, Habib, Nazia, Smith, Tracey L., Bruiners, Natalie, Sidman, Richard L., Gennaro, Maria L., Lattime, Edmund C., Libutti, Steven K., Whitford, Paul C., Burley, Stephen K., Onuchic, José N., Arap, Wadih, Pasqualini, Renata

“…Development of effective vaccines against coronavirus disease 2019 (COVID-19) is a global imperative. Rapid immunization of the entire human population against…”
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B7 immune-checkpoints as targets for the treatment of neuroendocrine tumors by Yuan, Ziqiang, Gardiner, Juliet C, Maggi, Elaine C, Huang, Shuyu, Adem, Asha, Bagdasarov, Svetlana, Li, Guiying, Lee, Sylvia, Slegowski, Daniel, Exarchakis, Alyssa, Howe, James R, Lattime, Edmund C, Zang, Xingxing, Libutti, Steven K

“…The B7 family, and their receptors, the CD28 family, are major immune checkpoints that regulate T-cell activation and function. In the present study, we…”
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Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response by Poillet-Perez, Laura, Sharp, Daniel W, Yang, Yang, Laddha, Saurabh V, Ibrahim, Maria, Bommareddy, Praveen K, Hu, Zhixian Sherrie, Vieth, Joshua, Haas, Michael, Bosenberg, Marcus W, Rabinowitz, Joshua D, Cao, Jian, Guan, Jun-Lin, Ganesan, Shridar, Chan, Chang S, Mehnert, Janice M, Lattime, Edmund C, White, Eileen

“…Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy…”
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A National Multicenter Phase 2 Study of Prostate-specific Antigen (PSA) Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression: ECOG 9802 by DiPaola, Robert S, Chen, Yu-Hui, Bubley, Glenn J, Stein, Mark N, Hahn, Noah M, Carducci, Michael A, Lattime, Edmund C, Gulley, James L, Arlen, Philip M, Butterfield, Lisa H, Wilding, George

“…Abstract Background E9802 was a phase 2 multi-institution study conducted to evaluate the safety and effectiveness of vaccinia and fowlpox prostate-specific…”
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Tumor-induced interleukin 10 suppresses the ability of splenic dendritic cells to stimulate CD4 and CD8 T-cell responses by YANG, Arvin S, LATTIME, Edmund C

“…Dendritic cell (DC) maturation and function are influenced by the surrounding cytokine milieu. We demonstrate tumor-associated suppression of DCs in…”
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Phase I neoadjuvant study of intravesical recombinant fowlpox-GM-CSF (rF-GM-CSF) or fowlpox-TRICOM (rF-TRICOM) in patients with bladder carcinoma by Portal, Daniella E., Weiss, Robert E., Wojtowicz, Malgorzata, Mansour, Amal, Monken, Claude, Mehnert, Janice M., Aisner, Joseph A., Kane, Michael, Nishioka, Jennifer, Aisner, Seena, Peters, Stephen, Stein, Mark N., Kim, Isaac Y., Mayer, Tina M., Shih, Weichung, Gulley, James, Streicher, Howard, Singer, Eric A., Lattime, Edmund C.

“…Intravesical BCG is a highly effective treatment for high-grade nonmuscle invasive bladder cancer and carcinoma in situ (CIS); however, for patients who are…”
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Antineoplastic Effects of Partially HLA-Matched Irradiated Blood Mononuclear Cells in Patients With Renal Cell Carcinoma by STRAIR, Roger K, SCHAAR, Dale, BAKER, Christina, DUDEK, Liesel, CIARDELLA, Marie, KURIYAN, Mercy, RUBIN, Arnold, LATTIME, Edmund C, MEDINA, Daniel, TODD, Mary B, AISNER, Joseph, DIPAOLA, Robert S, MANAGO, Jacqueline, KNOX, Beth, JENKINSON, Amanda, SENZON, Rachelle

“…Vaccines, cytokines, and other biologic-based therapies are being developed as antineoplastic agents. Many of these agents are designed to induce an autologous…”
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350 Phase I Trial of Endoscopic Ultrasound (EUS) Guided Intratumoral Vaccination With Recombinant Panvac-F and Systemic Panvac-V in Patients With Locally Advanced Pancreatic Cancer by Repaka, Aparna, Poplin, Elizabeth a, August, David a, Ben-Menachem, Tamir, Michael, Hazar, Artymyshyn, Renee, Lattime, Edmund C

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Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response by Poillet-Perez, Laura, Sharp, Daniel W, Yang, Yang, Laddha, Saurabh V, Ibrahim, Maria, Bommareddy, Praveen K, Hu, Zhixian Sherrie, Vieth, Joshua, Haas, Michael, Bosenberg, Marcus W, Rabinowitz, Joshua D, Cao, Jian, Guan, Jun-Lin, Ganesan, Shridar, Chan, Chang S, Mehnert, Janice M, Lattime, Edmund C, White, Eileen

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Anti-CTL -associated antigen 4 : Are regulatory T cells a target? by GABRIEL, Emmanuel M, LATTIME, Edmund C

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