Search Results - "Latour, Yvonne"

The role of polyamines in the regulation of macrophage polarization and function by Latour, Yvonne L., Gobert, Alain P., Wilson, Keith T.

“…Naturally occurring polyamines are ubiquitously distributed and play important roles in cell development, amino acid and protein synthesis, oxidative DNA…”
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Protective Role of Spermidine in Colitis and Colon Carcinogenesis by Gobert, Alain P., Latour, Yvonne L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Finley, Jordan L., Smith, Thaddeus M., McNamara, Kara M., Singh, Kshipra, Sierra, Johanna C., Delgado, Alberto G., Luis, Paula B., Schneider, Claus, Washington, M. Kay, Piazuelo, M. Blanca, Zhao, Shilin, Coburn, Lori A., Wilson, Keith T.

“…Because inflammatory bowel disease is increasing worldwide and can lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown that…”
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Turicibacterales protect mice from severe Citrobacter rodentium infection by Hoek, Kristen L, McClanahan, Kathleen G, Latour, Yvonne L, Shealy, Nicolas, Piazuelo, M Blanca, Vallance, Bruce A, Byndloss, Mariana X, Wilson, Keith T, Olivares-Villagómez, Danyvid

“…One of the major contributors to child mortality in the world is diarrheal diseases, with an estimated 800,000 deaths per year. Many pathogens are causative…”
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Epithelial talin-1 protects mice from Citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity by Latour, Yvonne L., Allaman, Margaret M., Barry, Daniel P., Smith, Thaddeus M., Williams, Kamery J., McNamara, Kara M., Jacobse, Justin, Goettel, Jeremy A., Delgado, Alberto G., Piazuelo, M. Blanca, Zhao, Shilin, Gobert, Alain P., Wilson, Keith T.

“…Pathogenic enteric Escherichia coli present a significant burden to global health. Food-borne enteropathogenic E. coli (EPEC) and Shiga toxin-producing E. coli…”
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Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification by Gobert, Alain P., Smith, Thaddeus M., Latour, Yvonne L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Williams, Kamery J., McNamara, Kara M., Delgado, Alberto G., Short, Sarah P., Mirmira, Raghavendra G., Rose, Kristie L., Schey, Kevin L., Zagol-Ikapitte, Irene, Coleman, Jeremy S., Boutaud, Olivier, Zhao, Shilin, Piazuelo, M. Blanca, Washington, M. Kay, Coburn, Lori A., Wilson, Keith T.

“…The amino acid hypusine, synthesized from the polyamine spermidine by the enzyme deoxyhypusine synthase (DHPS), is essential for the activity of eukaryotic…”
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Hypusination Orchestrates the Antimicrobial Response of Macrophages by Gobert, Alain P., Finley, Jordan L., Latour, Yvonne L., Asim, Mohammad, Smith, Thaddeus M., Verriere, Thomas G., Barry, Daniel P., Allaman, Margaret M., Delagado, Alberto G., Rose, Kristie L., Calcutt, M. Wade, Schey, Kevin L., Sierra, Johanna C., Piazuelo, M. Blanca, Mirmira, Raghavendra G., Wilson, Keith T.

“…Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the…”
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Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis by Gobert, Alain P., Boutaud, Olivier, Asim, Mohammad, Zagol-Ikapitte, Irene A., Delgado, Alberto G., Latour, Yvonne L., Finley, Jordan L., Singh, Kshipra, Verriere, Thomas G., Allaman, Margaret M., Barry, Daniel P., McNamara, Kara M., Sierra, Johanna C., Amarnath, Venkataraman, Tantawy, Mohammed N., Bimczok, Diane, Piazuelo, M. Blanca, Washington, M. Kay, Zhao, Shilin, Coburn, Lori A., Wilson, Keith T.

“…Inflammation in the gastrointestinal tract may lead to the development of cancer. Dicarbonyl electrophiles, such as isolevuglandins (isoLGs), are generated…”
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Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells by Jacobse, Justin, Brown, Rachel E., Li, Jing, Pilat, Jennifer M., Pham, Ly, Short, Sarah P., Peek, Christopher T., Rolong, Andrea, Washington, M. Kay, Martinez-Barricarte, Ruben, Byndloss, Mariana X., Shelton, Catherine, Markle, Janet G., Latour, Yvonne L., Allaman, Margaret M., Cassat, James E., Wilson, Keith T., Choksi, Yash A., Williams, Christopher S., Lau, Ken S., Flynn, Charles R., Casanova, Jean-Laurent, Rings, Edmond H.H.M., Samsom, Janneke N., Goettel, Jeremy A.

“…The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R…”
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Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production by McNamara, Kara M., Sierra, Johanna C., Latour, Yvonne L., Hawkins, Caroline V., Asim, Mohammad, Williams, Kamery J., Barry, Daniel P., Allaman, Margaret M., Zagol-Ikapitte, Irene, Luis, Paula B., Schneider, Claus, Delgado, Alberto G., Piazuelo, M. Blanca, Tyree, Regina N., Carson, Kate S., Choksi, Yash A., Coburn, Lori A., Gobert, Alain P., Wilson, Keith T.

“…Abstract Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for therapeutic intervention in H…”
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Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation by Latour, Yvonne L., McNamara, Kara M., Allaman, Margaret M., Barry, Daniel P., Smith, Thaddeus M., Asim, Mohammad, Williams, Kamery J., Hawkins, Caroline V., Jacobse, Justin, Goettel, Jeremy A., Delgado, Alberto G., Piazuelo, M. Blanca, Washington, M. Kay, Gobert, Alain P., Wilson, Keith T.

“…The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major…”
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Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis by Latour, Yvonne L., Yoon, Robin, Thomas, Sarah E., Grant, Christina, Li, Cuiling, Sena-Esteves, Miguel, Allende, Maria L., Proia, Richard L., Tifft, Cynthia J.

“…GM1 gangliosidosis is an autosomal recessive neurodegenerative disorder caused by the deficiency of lysosomal β-galactosidase (β-gal) and resulting in…”
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The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice by Gobert, Alain P., Latour, Yvonne L., McNamara, Kara M., Hawkins, Caroline V., Williams, Kamery J., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Delgado, Alberto G., Milne, Ginger L., Zhao, Shilin, Piazuelo, M. Blanca, Washington, M. Kay, Coburn, Lori A., Wilson, Keith T.

“…Cystathionine γ-lyase (CTH) is a critical enzyme in the reverse transsulfuration pathway, the major route for the metabolism of sulfur-containing amino acids,…”
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Risks and benefits of anesthesia for combined pediatric procedures in the NIH undiagnosed diseases program by Macnamara, Ellen F., Loydpierson, Amelia, Latour, Yvonne L., D'Souza, Precilla, Murphy, Jennifer, Wolfe, Lynne, Estwick, Tyra, Johnston, Jean M., Yang, John, Acosta, Maria T., Lee, Paul R., Pierson, Tyler Mark, Soldatos, Ariane, Toro, Camilo, Markello, Tom, Adams, David R., Gahl, William A., Yousef, Muhammad, Tifft, Cynthia J.

“…The NIH Undiagnosed Diseases Program (UDP) aims to provide diagnoses to patients who have previously received exhaustive evaluations yet remain undiagnosed…”
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Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection by Latour, Yvonne L., Sierra, Johanna C., McNamara, Kara M., Smith, Thaddeus M., Luis, Paula B., Schneider, Claus, Delgado, Alberto G., Barry, Daniel P., Allaman, Margaret M., Calcutt, M. Wade, Schey, Kevin L., Piazuelo, M. Blanca, Gobert, Alain P., Wilson, Keith T.

“…Abstract Colonization by Helicobacter pylori is associated with gastric diseases, ranging from superficial gastritis to more severe pathologies, including…”
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Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway by Gobert, Alain P, Latour, Yvonne L, Asim, Mohammad, Finley, Jordan L, Verriere, Thomas G, Barry, Daniel P, Milne, Ginger L, Luis, Paula B, Schneider, Claus, Rivera, Emilio S, Lindsey-Rose, Kristie, Schey, Kevin L, Delgado, Alberto G, Sierra, Johanna C, Piazuelo, M Blanca, Wilson, Keith T

“…The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage…”
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Novel Biomarkers of Human GM1 Gangliosidosis Reflect the Clinical Efficacy of Gene Therapy in a Feline Model by Gray-Edwards, Heather L., Regier, Debra S., Shirley, Jamie L., Randle, Ashley N., Salibi, Nouha, Thomas, Sarah E., Latour, Yvonne L., Johnston, Jean, Golas, Gretchen, Maguire, Annie S., Taylor, Amanda R., Sorjonen, Donald C., McCurdy, Victoria J., Christopherson, Peter W., Bradbury, Allison M., Beyers, Ronald J., Johnson, Aime K., Brunson, Brandon L., Cox, Nancy R., Baker, Henry J., Denney, Thomas S., Sena-Esteves, Miguel, Tifft, Cynthia J., Martin, Douglas R.

“…GM1 gangliosidosis is a fatal neurodegenerative disease that affects individuals of all ages. Favorable outcomes using adeno-associated viral (AAV) gene…”
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Rapid Identification of New Biomarkers for the Classification of GM1 Type 2 Gangliosidosis Using an Unbiased 1H NMR-Linked Metabolomics Strategy by Percival, Benita C., Latour, Yvonne L., Tifft, Cynthia J., Grootveld, Martin

“…Biomarkers currently available for the diagnosis, prognosis, and therapeutic monitoring of GM1 gangliosidosis type 2 (GM1T2) disease are mainly limited to…”
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Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation by Latour, Yvonne L., Sierra, Johanna C., Finley, Jordan L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Smith, Thaddeus M., McNamara, Kara M., Luis, Paula B., Schneider, Claus, Jacobse, Justin, Goettel, Jeremy A., Calcutt, M. Wade, Rose, Kristie L., Schey, Kevin L., Milne, Ginger L., Delgado, Alberto G., Piazuelo, M. Blanca, Paul, Bindu D., Snyder, Solomon H., Gobert, Alain P., Wilson, Keith T.

“…Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori , which infects half of the world’s population…”
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Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss by Peek, Christopher T., Ford, Caleb A., Eichelberger, Kara R., Jacobse, Justin, Torres, Teresa P., Maseda, Damian, Latour, Yvonne L., Piazuelo, M. Blanca, Johnson, Joshua R., Byndloss, Mariana X., Wilson, Keith T., Rathmell, Jeffrey C., Goettel, Jeremy A., Cassat, James E.

“…Inflammatory bowel disease (IBD) is characterized by severe gastrointestinal inflammation, but many patients experience extra-intestinal disease. Bone loss is…”
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Whole genome sequencing reveals novel IGHMBP2 variant leading to unique cryptic splice‐site and Charcot‐Marie‐Tooth phenotype with early onset symptoms by Cassini, Thomas A., Rives, Lynette C., Newman, John H., Koziura, Mary E., Hamid, Rizwan, Adams, Christopher, Adams, David, Alejandro, Mercedes, Allard, Patrick, Ashley, Euan, Bacino, Carlos, Balasubramanyam, Ashok, Barseghyan, Hayk, Bellen, Hugo, Boone, Braden, Bostwick, Bret, Briere, Lauren, Burke, Elizabeth, Burrage, Lindsay, Chao, Katherine, Clark, Gary, Dhar, Shweta, Donnell‐Fink, Laurel, Eckstein, David, Frisby, Trevor, Gartner, Valerie, Godfrey, Rena, Goheen, Mitchell, Golas, Gretchen, Goldstein, David, Gordon, Mary, Gould, Sarah, Gourdine, Jean‐Philippe, Hanchard, Neil, Handley, Lori, Herzog, Matthew, Holm, Ingrid, Howerton, Ellen, Jacob, Howard, Jain, Mahim, Jiang, Yong‐hui, Johnston, Jean, Jones, Angela, Koehler, Alanna, Kohler, Jennefer, Krier, Joel, Lalani, Seema, Latour, Yvonne, Lee, Brendan, Lee, Hane, Lee, Paul, Levy, Shawn, Lewis, Richard, Lincoln, Sharyn, Loscalzo, Joseph, Maas, Richard, MacRae, Calum, Malicdan, May Christine, Mamounas, Laura, McCarty, Alexandra, McCray, Alexa, Might, Matthew, Mulvihill, John, Murphy, Jennifer, Muzny, Donna, Nehrebecky, Michele, Nelson, Stan, Novacic, Donna, Carl Pallais, J, Posey, Jennifer, Potocki, Lorraine, Ramoni, Rachel, Rodan, Lance, Rosenfeld, Jill, Samson, Susan, Schaffer, Katherine, Sharma, Prashant, Shashi, Vandana, Silverman, Edwin, Soldatos, Ariane, Spillmann, Rebecca, Splinter, Kimberly, Stoler, Joan, Stong, Nicholas, Strong, Kimberly, Sullivan, Jennifer, Tifft, Cynthia, Vilain, Eric, Vogel, Tiphanie, Waggott, Daryl, Wahl, Colleen, Waters, Katrina, Webb‐Robertson, Bobbie‐Jo, Westerfield, Monte, Wheeler, Matthew, Wise, Anastasia, Wolfe, Lynne, Worthey, Elizabeth, Yamamoto, Shinya, Yang, Yaping

“…Background Rare variants (RV) in immunoglobulin mu‐binding protein 2 (IGHMBP2) [OMIM 600502] can cause an autosomal recessive type of Charcot‐Marie‐Tooth (CMT)…”
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