Controlled Delivery of Celecoxib-β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Controlled Delivery of Celecoxib-β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers

Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate the possibility of creating a functional drug delivery system based on anodic TiO for celecoxib as an alternative anti-inflammatory drug and its inclusion complex with β-cyclodex...

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Bibliographic Details
Published in:Pharmaceutics Vol. 15; no. 7; p. 1861
Main Authors: Jarosz, Magdalena, Latosiński, Jakub, Gumułka, Paweł, Dąbrowska, Monika, Kępczyński, Mariusz, Sulka, Grzegorz Dariusz, Starek, Małgorzata
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-07-2023
MDPI
Subjects:
Angiogenesis inhibitors
Bioavailability
Biocompatibility
Biomedical materials
Bone surgery
Celecoxib
Cyclodextrins
drug delivery
Drug delivery systems
Drugs
Edema
Electrolytes
inclusion complexes
Inflammation
Intraocular lenses
Lung cancer
Medical research
Medicine, Experimental
Nanoparticles
nanostructured titanium dioxide
Narcotics
Titanium
Titanium dioxide
Transplants & implants
Vehicles
β-cyclodextrin
nanostructured titanium dioxide
drug delivery
celecoxib
β-cyclodextrin
inclusion complexes
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Summary:Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate the possibility of creating a functional drug delivery system based on anodic TiO for celecoxib as an alternative anti-inflammatory drug and its inclusion complex with β-cyclodextrin. First, the optimal composition of celecoxib-β-cyclodextrin complexes was synthesized and determined. The effectiveness of the complexation was quantified using isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR) nuclear magnetic resonance ( H NMR), and scanning electron microscopy (SEM). Then, nanostructured titanium dioxide layers (TiO ) were synthesized using the electrochemical oxidation technique. The TiO layers with pore diameters of 60 nm and layer thickness of 1.60 µm were used as drug delivery systems. The samples were modified with pure celecoxib and the β-cyclodextrin-celecoxib complex. The release profiles shown effective drug release from such layers during 24 h. After the initial burst release, the drug was continuously released from the pores. The presented results confirm that the use of nanostructured TiO as a drug delivery system can be effectively used in more complicated systems composed of β-cyclodextrin-celecoxib complexes, making such drugs available for pain treatment, e.g., for orthopedic surgeries.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15071861