Search Results - "Latinovic, Olga"

Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy by Zhang, Yan, Du, Xuexiang, Liu, Mingyue, Tang, Fei, Zhang, Peng, Ai, Chunxia, Fields, James K., Sundberg, Eric J., Latinovic, Olga S., Devenport, Martin, Zheng, Pan, Liu, Yang

“…It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects…”
Get full text

Past HIV-1 Medications and the Current Status of Combined Antiretroviral Therapy Options for HIV-1 Patients by Weichseldorfer, Matthew, Reitz, Marvin, Latinovic, Olga S.

“…Combined antiretroviral therapy (cART) is treatment with a combination of several antiretroviral drugs that block multiple stages in the virus replication…”
Get full text

The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope by Affram, Yvonne, Zapata, Juan C, Gholizadeh, Zahra, Tolbert, William D, Zhou, Wei, Iglesias-Ussel, Maria D, Pazgier, Marzena, Ray, Krishanu, Latinovic, Olga S, Romerio, Fabio

“…The negative strand of HIV-1 encodes a highly hydrophobic antisense protein (ASP) with no known homologs. The presence of humoral and cellular immune responses…”
Get full text

Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies by Weichseldorfer, Matthew, Tagaya, Yutaka, Reitz, Marvin, DeVico, Anthony L, Latinovic, Olga S

“…The chemokine receptor CCR5 is the major coreceptor for HIV-1 cell entry. We previously observed that not all CCR5 mAbs reduce HIV-1 infection, suggesting that…”
Get full text

Mycoplasma DnaK increases DNA copy number variants in vivo by Benedetti, Francesca, Silvestri, Giovannino, Saadat, Saman, Denaro, Frank, Latinovic, Olga S, Davis, Harry, Williams, Sumiko, Bryant, Joseph, Ippodrino, Rudy, Rathinam, Chozha V, Gallo, Robert C, Zella, Davide

“…The human microbiota affects critical cellular functions, although the responsible mechanism(s) is still poorly understood. In this regard, we previously…”
Get full text

Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties by Zella, Davide, Curreli, Sabrina, Benedetti, Francesca, Krishnan, Selvi, Cocchi, Fiorenza, Latinovic, Olga S, Denaro, Frank, Romerio, Fabio, Djavani, Muhammad, Charurat, Man E, Bryant, Joseph L, Tettelin, Hervé, Gallo, Robert C

“…We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in…”
Get full text

Role of Mycoplasma Chaperone DnaK in Cellular Transformation by Benedetti, Francesca, Cocchi, Fiorenza, Latinovic, Olga S, Curreli, Sabrina, Krishnan, Selvi, Munawwar, Arshi, Gallo, Robert C, Zella, Davide

“…Studies of the human microbiome have elucidated an array of complex interactions between prokaryotes and their hosts. However, precise bacterial…”
Get full text

Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells by Benedetti, Francesca, Silvestri, Giovannino, Mavian, Carla, Weichseldorfer, Matthew, Munawwar, Arshi, Cash, Melanie N, Dulcey, Melissa, Vittor, Amy Y, Ciccozzi, Massimo, Salemi, Marco, Latinovic, Olga S, Zella, Davide

“…SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) is primarily responsible for coronavirus disease (COVID-19) and it is characterized by respiratory…”
Get full text

Combined cART including Tenofovir Disoproxil, Emtricitabine, and Dolutegravir has potent therapeutic effects in HIV-1 infected humanized mice by Weichseldorfer, Matthew, Affram, Yvonne, Heredia, Alonso, Rikhtegaran-Tehrani, Zahra, Sajadi, Mohammad M, Williams, Sumiko P, Tagaya, Yutaka, Benedetti, Francesca, Ramadhani, Habib O, Denaro, Frank, Munawwar, Arshi, Bryant, Joseph, Zella, Davide, Reitz, Marvin, Romerio, Fabio, Latinovic, Olga S

“…HIV-1 reservoirs persist in the presence of combined antiretroviral therapy (cART). However, cART has transformed HIV-1 infection into a chronic disease marked…”
Get full text

Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties by Zella, Davide, Curreli, Sabrina, Benedetti, Francesca, Krishnan, Selvi, Cocchi, Fiorenza, Latinovic, Olga S., Denaro, Frank, Romerio, Fabio, Djavani, Mahmoud, Charurat, Man E., Bryant, Joseph L., Tettelin, Hervé, Gallo, Robert C.

“…We isolated a strain of human mycoplasma that promotes lymphomagenesis in SCID mice, pointing to a p53-dependent mechanism similar to lymphomagenesis in…”
Get full text

Cauliflower Mosaic Virus TAV, a Plant Virus Protein That Functions like Ribonuclease H1 and is Cytotoxic to Glioma Cells by Abbati, Giulia, Sarnelli, Anna, Ratti, Claudio, Massi, Paola, Schoelz, James E., Salvato, Maria S., Piccinini, Filippo, Martinelli, Giovanni, Vagheggini, Alessandro, Martelli, Pier Luigi, Calassanzio, Matteo, Parigi, Maria, Toyang, Ngeh, Bonafè, Massimiliano, Latinovic, Olga S., Turri, Valentina, Casadio, Rita

“…Recent comparisons between plant and animal viruses reveal many common principles that underlie how all viruses express their genetic material, amplify their…”
Get full text

Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1 by Heredia, Alonso, Latinovic, Olga, Gallo, Robert C, Melikyan, Gregory, Reitz, Marv, Le, Nhut, Redfield, Robert R

“…Vicriviroc (VCV) is a chemokine (C-C motif) receptor 5 (CCR5) antagonist with potent anti-HIV activity that currently is being evaluated in phase III clinical…”
Get full text

Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of β chemokines and RNases by Cocchi, Fiorenza, DeVico, Anthony L, Lu, Wuyuan, Popovic, Mikulas, Latinovic, Olga, Sajadi, Mohammad M, Redfield, Robert R, Lafferty, Mark K, Galli, Massimo, Garzino-Demo, Alfredo, Gallo, Robert C

“…T-cell-derived soluble factors that inhibit both X4 and R5 HIV are recognized as important in controlling HIV. Whereas three β chemokines,…”
Get full text

Full Length Single Chain Fc Protein (FLSC IgG1) as a Potent Antiviral Therapy Candidate: Implications for In Vivo Studies by Latinovic, Olga S, Medina-Moreno, Sandra, Schneider, Kate, Gohain, Neelakshi, Zapata, Juan, Pazgier, Marzena, Reitz, Marvin, Bryant, Joseph, Redfield, Robert R

“…We have previously shown that FLSC, a chimeric protein containing HIV-1BAL gp120 and the D1 and D2 domains of human CD4, blocks the binding and entry of HIV-1…”
Get more information

The HIV-1 Transgenic Rat: Relevance for HIV Noninfectious Comorbidity Research by Denaro, Frank, Benedetti, Francesca, Worthington, Myla D., Scapagnini, Giovanni, Krauss, Christopher C., Williams, Sumiko, Bryant, Joseph, Davis, Harry, Latinovic, Olga S., Zella, Davide

“…HIV noninfectious comorbidities (NICMs) are a current healthcare challenge. The situation is further complicated as there are very few effective models that…”
Get full text

Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion by Jha, Naveen K, Latinovic, Olga, Martin, Erik, Novitskiy, Gennadiy, Marin, Mariana, Miyauchi, Kosuke, Naughton, John, Young, John A T, Melikyan, Gregory B

“…A large group of viruses rely on low pH to activate their fusion proteins that merge the viral envelope with an endosomal membrane, releasing the viral…”
Get full text

Synergistic Inhibition of R5 HIV-1 by the Fusion Protein (FLSC) IgG1 Fc and Maraviroc in Primary Cells: Implications for Prevention and Treatment by Latinovic, Olga S, Zhang, Jian, Tagaya, Yutaka, DeVico, Anthony L, Fouts, Timothy R, Schneider, K, Lakowicz, Joseph R, Heredia, Alonso, Redfield, Robert R

“…Antiretroviral (ARV) drugs targeting retroviral enzymes have been extensively employed to treat HIV-1 infection. Drawbacks of this approach include cost,…”
Get more information

Structural and micromechanical characterization of type I collagen gels by Latinovic, Olga, Hough, Lawrence A, Daniel Ou-Yang, H

“…Abstract In this paper we report a study where we use a novel optical tweezers technique to measure the local viscoelastic properties of type I collagen…”
Get full text

Shiga toxin type-2 (Stx2) induces glutamate release via phosphoinositide 3-kinase (PI3K) pathway in murine neurons by Obata, Fumiko, Hippler, Lauren M, Saha, Progyaparamita, Jandhyala, Dakshina M, Latinovic, Olga S

“…Shiga toxin-producing Escherichia coli (STEC) can cause central nervous system (CNS) damage resulting in paralysis, seizures, and coma. The key STEC virulence…”
Get full text

A novel small-molecule inhibitor of HIV-1 entry by Heredia, Alonso, Latinovic, Olga S, Barbault, Florent, de Leeuw, Erik P H

“…Antiretroviral therapy has transformed HIV-1 infection into a managed condition with near-normal life expectancy. However, a significant number of patients…”
Get full text