Search Results - "Lathrop, D A"

Ionic currents and action potentials in rabbit, rat, guinea pig ventricular myocytes by VARRO, A, LATHROP, D. A, HESTER, S. B, NANASI, P. P, PAPP, J. G. Y

“…Distinct differences exist in action potentials and ionic currents between rabbit, rat, and guinea pig ventricular myocytes. Data obtained at room temperature…”
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Effects of temperature on cycle length dependent changes and restitution of action potential duration in guinea pig ventricular muscle by Bjørnstad, H, Tande, P M, Lathrop, D A, Refsum, H

“…The aim was to investigate the effects of temperature on cycle length dependent changes of action potential duration and on restitution of action potential…”
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Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes by Yang, T, Tande, P M, Lathrop, D A, Refsum, H

“…The aim was to examine the electromechanical effects of dofetilide, a new class III antiarrhythmic agent, in isolated guinea pig ventricular muscle during…”
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Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration by Lengyel, C, Iost, N, Virág, L, Varró, A, Lathrop, D A, Papp, J G

“…1. The effects of I(Ks) block by chromanol 293B and L-735,821 on rabbit QT-interval, action potential duration (APD), and membrane current were compared to…”
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Vasoactive Intestinal Polypeptide Facilitates Atrioventricular Nodal Conduction and Shortens Atrial and Ventricular Refractory Periods in Conscious and Anesthetized Dogs by Rigel, Dean F, Lathrop, David A

“…Our study was designed to determine the cardiac electrophysiological influence of vasoactive intestinal polypeptide (VIP) in conscious dogs. Dogs (n=8) were…”
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Potassium currents in isolated human atrial and ventricular cardiocytes by Varró, A, Nánási, P P, Lathrop, D A

“…The whole-cell configuration of the patch-clamp technique was applied to study and compare ion currents in single ventricular and atrial cardiocytes isolated…”
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The combined electrophysiological effects of lignocaine and sotalol in canine isolated cardiac Purkinje fibres are rate‐dependent by Lathrop, David A., Varró, András

“…1 The frequency‐dependent electrophysiological effects of lignocaine, sotalol, and their combination were studied in dog isolated cardiac Purkinje fibres, both…”
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Vasoactive intestinal polypeptide enhances automaticity of supraventricular pacemakers in anesthetized dogs by Rigel, D F, Lathrop, D A

“…Effects of the cardiac neuropeptide vasoactive intestinal polypeptide (VIP) and isoproterenol (ISO) were compared on sinus nodal, subsidiary atrial, and…”
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In vitro cardiac models of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil by Lathrop, David A., Nànàsi, Pèter P., Varrò, Andràs

“…1 The effects of nicorandil (30 μm and 100 μm) on two models of triggered activity [early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs)]…”
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Slow inward calcium currents have no obvious role in muscle excitation-contraction coupling by Gonzalez-Serratos, H, Valle-Aguilera, R, Lathrop, D. A, del Carmen Garcia, Maria

“…It has been proposed that an influx of calcium ions into twitch muscle fibres during an action potential might initiate contraction. However, when external…”
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Insulin-induced hyperpolarization in mammalian skeletal muscle by Iannaccone, S T, Li, K X, Sperelakis, N, Lathrop, D A

“…Insulin-induced hyperpolarization of up to 9 mV has been described in isolated frog [J. Physiol. Lond. 252: 43-58, 1975; Am. J. Physiol. 251 (Cell Physiol. 4):…”
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Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212 by RAPUNDALO, S. T, LATHROP, D. A, HARRISON, S. A, BEAVO, J. A, SCHWARTZ, A

“…Possible cAMP-dependent and cAMP-independent mechanisms of action for the cardiac effects of OPC-8212, a novel piperazinyl-quinolinone derivative, were…”
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Rate and concentration‐dependent effects of UK‐68,798, a potent new class III antiarrhythmic, on canine Purkinje fibre action potential duration and Vmax by Knilans, Timothy K., Lathrop, David A., Nánási, Péter P., Schwartz, Arnold, Varró, András

“…1 The frequency‐dependent electrophysiological effects of UK‐68,798 in concentrations of 1, 3, 10 and 30 nm were examined in isolated cardiac Purkinje fibres…”
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Electromechanical characterization of the effects of racemic sotalol and its optical isomers on isolated canine ventricular trabecular muscles and Purkinje strands by Lathrop, D A

“…In both isolated canine ventricular trabecular muscle and Purkinje strand preparations, dl-sotalol and its two optical isomers d- and l-sotalol produced a…”
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Prevention of some hypothermia induced electromechanical changes by calcium channel blockade by Bjørnstad, H, Lathrop, D A, Refsum, H

“…Cooling induces electromechanical changes in the heart. The aim of the study was to examine how the calcium channel blocker, nisoldipine (NIS), altered these…”
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Ionic basis for OPC-8212-induced increase in action potential duration in isolated rabbit, guinea pig and human ventricular myocytes by Lathrop, D A, Nánási, P P, Schwartz, A, Varró, A

“…Changes in transmembrane ionic currents induced by OPC-8212 (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline) , a recently introduced…”
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Effects of the optical isomers of verapamil on electrophysiological properties of the heart in conscious dogs by Takahata, Osamu, Krolikowski, John G, McCallum, John B, Lathrop, David A, Bosnjak, Zeljko J

“…We compared the cumulative dose–response relations of verapamil (0.1, 0.2 and 0.4 mg kg −1) in different R/ S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and…”
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Effect of stimulation and veratrine on total cellular calcium in rat and guinea-pig ventricular myocytes by HENDEN, T, LARSEN, T. S, LATHROP, D. A

“…In rat cardiac myocytes, calcium efflux by Na+/Ca(2+)-exchange is expected only during ventricular systole following initial action potential repolarization…”
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Modulation of the effects of sotalol on Purkinje strand electromechanical characteristics by Lathrop, D A, Varró, A

“…The modulation of the effects of sotalol (30 microM) by two sodium channel blockers, tetrodotoxin (0.07 microM) and lidocaine (50 microM), and by a potassium…”
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Rate-dependent electrophysiological effects of OPC-8212: comparison to sotalol by Lathrop, D A, Varró, A, Schwartz, A

“…The rate-dependent effects of OPC-8212 (6 microM), a new positive inotropic drug which lengthens cardiac action potential duration were studied in dog cardiac…”
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