Search Results - "Lathia, Justin"

Cancer stem cell–immune cell crosstalk in tumour progression by Bayik, Defne, Lathia, Justin D.

“…Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent yet synergistic drivers of tumour progression and underlie therapeutic…”
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Targeting Cancer Stemness in the Clinic: From Hype to Hope by Saygin, Caner, Matei, Daniela, Majeti, Ravindra, Reizes, Ofer, Lathia, Justin D.

“…Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of genetic and functional heterogeneity. Cancer stem cells (CSCs) are…”
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Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth by Cheng, Lin, Huang, Zhi, Zhou, Wenchao, Wu, Qiulian, Donnola, Shannon, Liu, James K., Fang, Xiaoguang, Sloan, Andrew E., Mao, Yubin, Lathia, Justin D., Min, Wang, McLendon, Roger E., Rich, Jeremy N., Bao, Shideng

“…Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular hierarchies containing self-renewing tumorigenic glioma stem cells…”
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Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors by Lauko, Adam, Lo, Alice, Ahluwalia, Manmeet S., Lathia, Justin D.

“…Brain tumors remain one of the most difficult tumors to treat and, depending on the diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is…”
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Skull bones harbour immune cells that are poised to target brain tumours by Lee, Juyeun, Lathia, Justin D.

“…The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed…”
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Cancer stem cells in glioblastoma by Lathia, Justin D, Mack, Stephen C, Mulkearns-Hubert, Erin E, Valentim, Claudia L L, Rich, Jeremy N

“…Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate…”
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The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors by Lee, Juyeun, Lathia, Justin D.

“…Diffuse midline gliomas (DMGs) pose treatment challenges due to their location within the brainstem and invasive nature. Although classical immune checkpoint…”
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The Clinical Impact of Cancer Stem Cells by Lathia, Justin, Liu, Huiping, Matei, Daniela

“…Patients with cancer can go though many stages in their disease, including diagnosis, recurrence, metastasis, and treatment failure. Cancer stem cells (CSCs)…”
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Overview of Cancer Stem Cells and Stemness for Community Oncologists by Lathia, Justin D., Liu, Huiping

“…Advances in cancer research in the past have led to an evolving understanding of cancer pathogenesis and the development of novel drugs that significantly…”
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The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions by Mitchell, Kelly, Troike, Katie, Silver, Daniel J, Lathia, Justin D

“…Abstract Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a population of self-renewing, therapeutically resistant…”
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Antibody-cytokine fusion breathes new life into glioblastoma therapy by Lee, Juyeun, Nicosia, Michael, Lathia, Justin D

“…An antibody-cytokine fusion molecule combined with chemotherapy induces tumor regression in mice and patients with recurrent glioblastoma by boosting antitumor…”
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Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment by Lathia, Justin D., Heddleston, John M., Venere, Monica, Rich, Jeremy N.

“…Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are…”
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A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer by Hubert, Christopher G, Stauffer, Shaun R, Lathia, Justin D

“…Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue…”
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Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2 by Eyler, Christine E., Wu, Qiulian, Yan, Kenneth, MacSwords, Jennifer M., Chandler-Militello, Devin, Misuraca, Katherine L., Lathia, Justin D., Forrester, Michael T., Lee, Jeongwu, Stamler, Jonathan S., Goldman, Steven A., Bredel, Markus, McLendon, Roger E., Sloan, Andrew E., Hjelmeland, Anita B., Rich, Jeremy N.

“…Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this…”
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Fountain of chaos: cerebrospinal fluid enhancement of cancer stem cells in glioblastoma by Lathia, Justin D

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Preinvasive to Invasive: PD-1-Expressing Macrophages Shift Lung Cancer into High Gear by Lee, Juyeun, Bayik, Defne, Lathia, Justin D

“…Lung adenocarcinoma is the most common subtype of lung cancer, which has the second highest incidence among cancers. Immunotherapy has revolutionized lung…”
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A circuitous route to GBM stem cell signalling by Mitchell, Kelly, Lathia, Justin D.

“…Circular RNAs regulate a variety of biological processes. Now an unexpected pathway is revealed in which a translated circular RNA derived from E-cadherin…”
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Optimising gene editing for cancer therapy by Troike, Katie, Lathia, Justin D.

“…Gene editing holds promise for the treatment of cancers that are driven by well-characterised molecular alterations. A study now provides a proof of concept…”
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Drak, Drak, Goose: A New Signaling Axis in Glioblastoma by Lathia, Justin D

“…While many molecular alterations in glioblastoma (GBM), the most common primary malignant brain tumor, have been defined, the intricate signaling networks…”
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Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells by Schonberg, David L., Miller, Tyler E., Wu, Qiulian, Flavahan, William A., Das, Nupur K., Hale, James S., Hubert, Christopher G., Mack, Stephen C., Jarrar, Awad M., Karl, Robert T., Rosager, Ann Mari, Nixon, Anne M., Tesar, Paul J., Hamerlik, Petra, Kristensen, Bjarne W., Horbinski, Craig, Connor, James R., Fox, Paul L., Lathia, Justin D., Rich, Jeremy N.

“…Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to…”
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