Search Results - "Latham, John A"

New developments in RiPP discovery, enzymology and engineering by Montalbán-López, Manuel, Scott, Thomas A, Ramesh, Sangeetha, Rahman, Imran R, van Heel, Auke J, Viel, Jakob H, Bandarian, Vahe, Dittmann, Elke, Genilloud, Olga, Goto, Yuki, Grande Burgos, María José, Hill, Colin, Kim, Seokhee, Koehnke, Jesko, Latham, John A, Link, A James, Martínez, Beatriz, Nair, Satish K, Nicolet, Yvain, Rebuffat, Sylvie, Sahl, Hans-Georg, Sareen, Dipti, Schmidt, Eric W, Schmitt, Lutz, Severinov, Konstantin, Süssmuth, Roderich D, Truman, Andrew W, Wang, Huan, Weng, Jing-Ke, van Wezel, Gilles P, Zhang, Qi, Zhong, Jin, Piel, Jörn, Mitchell, Douglas A, Kuipers, Oscar P, van der Donk, Wilfred A

“…Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven…”
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MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin by Ayikpoe, Richard S, Latham, John A

“…Mycofactocin (MFT) is a putative ribosomally synthesized and post-translationally modified (RiPP) redox cofactor. The biosynthesis of MFT is encoded by the…”
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Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms by Mason, Bianca N, Kaiser, Eric A, Kuburas, Adisa, Loomis, Maria-Cristina M, Latham, John A, Garcia-Martinez, Leon F, Russo, Andrew F

“…The neuropeptide calcitonin gene-related peptide (CGRP) is a key player in migraine. Although migraine can be treated using CGRP antagonists that act…”
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Mycofactocin Biosynthesis Proceeds through 3‑Amino-5-[(p‑hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE Specificity toward MftA by Ayikpoe, Richard, Salazar, Joe, Majestic, Brian, Latham, John A

“…The structure of the ribosomally synthesized and post-translationally modified peptide product mycofactocin is unknown. Recently, the first step in…”
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Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway by Koehn, Eric M, Latham, John A, Armand, Tara, Evans, Robert L, Tu, Xiongying, Wilmot, Carrie M, Iavarone, Anthony T, Klinman, Judith P

“…Understanding the biosynthesis of cofactors is fundamental to the life sciences, yet to date a few important pathways remain unresolved. One example is the…”
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Chromatin Signaling to Kinetochores: Transregulation of Dam1 Methylation by Histone H2B Ubiquitination by Latham, John A., Chosed, Renée J., Wang, Shanzhi, Dent, Sharon Y.R.

“…Histone H3K4 trimethylation by the Set1/MLL family of proteins provides a hallmark for transcriptional activity from yeast to humans. In S. cerevisiae, H3K4…”
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Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone by Latham, John A., Xia, Youlin, Klinman, Judith P., Wilmot, Carrie M.

“…Biosynthesis of the ribosomally synthesized and post-translationally modified peptide (RiPP), pyrroloquinoline quinone (PQQ), is initiated when the precursor…”
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Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide by Moldovan Loomis, Cristina, Dutzar, Benjamin, Ojala, Ethan W, Hendrix, Lee, Karasek, Charlie, Scalley-Kim, Michelle, Mulligan, Jenny, Fan, Pei, Billgren, Jens, Rubin, Vanessa, Boshaw, Heidi, Kwon, Gayle, Marzolf, Sam, Stewart, Erica, Jurchen, David, Pederson, Susan M, Perrino McCulloch, Lisa, Baker, Brian, Cady, Roger K, Latham, John A, Allison, Dan, Garcia-Martinez, Leon F

“…Migraine is a debilitating disease that affects almost 15% of the population worldwide and is the first cause of disability in people under 50 years of age,…”
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Divergence of Substrate Specificity and Function in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB by Latham, John A, Chen, Danqi, Allen, Karen N, Dunaway-Mariano, Debra

“…The work described in this paper, and its companion paper (Wu, R., Latham, J. A., Chen, D., Farelli, J., Zhao, H., Matthews, K. Allen, K. N., and…”
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Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB by Wu, Rui, Latham, John A, Chen, Danqi, Farelli, Jeremiah, Zhao, Hong, Matthews, Kaila, Allen, Karen N, Dunaway-Mariano, Debra

“…Herein, the structural determinants for substrate recognition and catalysis in two hotdog-fold thioesterase paralogs, YbdB and YdiI from Escherichia coli, are…”
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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation by Sutherland, May Kung, Geoghegan, James C., Yu, Changpu, Turcott, Eileen, Skonier, John E., Winkler, David G., Latham, John A.

“…A null mutation in the SOST gene is associated with sclerosteosis, an inherited disorder characterized by a high bone mass phenotype. The protein product of…”
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The Set1 Methyltransferase Opposes Ipl1 Aurora Kinase Functions in Chromosome Segregation by Zhang, Ke, Lin, Wenchu, Latham, John A., Riefler, Gary M., Schumacher, Jill M., Chan, Clarence, Tatchell, Kelly, Hawke, David H., Kobayashi, Ryuji, Dent, Sharon Y.R.

“…A balance in the activities of the Ipl1 Aurora kinase and the Glc7 phosphatase is essential for normal chromosome segregation in yeast. We report here that…”
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Regioselectivity of Enzymatic and Photochemical Single Electron Transfer Promoted Carbon−Carbon Bond Fragmentation Reactions of Tetrameric Lignin Model Compounds by Cho, Dae Won, Latham, John A, Park, Hea Jung, Yoon, Ung Chan, Langan, Paul, Dunaway-Mariano, Debra, Mariano, Patrick S

“…New types of tetrameric lignin model compounds, which contain the common β-O-4 and β-1 structural subunits found in natural lignins, have been prepared and…”
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Occurrence, function, and biosynthesis of mycofactocin by Ayikpoe, Richard, Govindarajan, Vishnu, Latham, John A.

“…Mycofactocin is a member of the rapidly growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Although…”
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Biosynthesis of the redox cofactor mycofactocin is controlled by the transcriptional regulator MftR and induced by long-chain acyl-CoA species by Mendauletova, Aigera, Latham, John A.

“…Mycofactocin (MFT) is a ribosomally synthesized and post-translationally-modified redox cofactor found in pathogenic mycobacteria. While MFT biosynthetic…”
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Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins by Winkler, David G., Sutherland, May S. Kung, Ojala, Ethan, Turcott, Eileen, Geoghegan, James C., Shpektor, Diana, Skonier, John E., Yu, Changpu, Latham, John A.

“…High bone mass diseases are caused both by activating mutations in the Wnt pathway and by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading…”
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Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC by Khaliullin, Bulat, Ayikpoe, Richard, Tuttle, Mason, Latham, John A.

“…Ribosomally synthesized and posttranslationally modified peptide (RiPP) pathways produce a diverse array of natural products. A subset of these pathways…”
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Demonstration That the Radical S-Adenosylmethionine (SAM) Enzyme PqqE Catalyzes de Novo Carbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD by Barr, Ian, Latham, John A., Iavarone, Anthony T., Chantarojsiri, Teera, Hwang, Jennifer D., Klinman, Judith P.

“…The radical S-adenosylmethionine (SAM) protein PqqE is predicted to function in the pyrroloquinoline quinone (PQQ) biosynthetic pathway via catalysis of…”
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Cross-regulation of histone modifications by Dent, Sharon Y R, Latham, John A

“…Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show…”
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Identification of a poly-cyclopropylglycine–containing peptide via bioinformatic mapping of radical S-adenosylmethionine enzymes by Kostenko, Anastasiia, Lien, Yi, Mendauletova, Aigera, Ngendahimana, Thacien, Novitskiy, Ivan M., Eaton, Sandra S., Latham, John A.

“…Peptide-derived natural products are a large class of bioactive molecules that often contain chemically challenging modifications. In the biosynthesis of…”
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