Search Results - "Latek, Robert R"

Mechanisms of Autoinhibition and STI-571/Imatinib Resistance Revealed by Mutagenesis of BCR-ABL by Azam, Mohammad, Latek, Robert R., Daley, George Q.

“…The Bcr-Abl fusion protein kinase causes chronic myeloid leukemia and is targeted by the signal transduction inhibitor STI-571/Gleevec/imatinib (STI-571)…”
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The transcription factor Eyes absent is a protein tyrosine phosphatase by Rebay, Ilaria, Tootle, Tina L, Silver, Serena J, Davies, Erin L, Newman, Victoria, Latek, Robert R, Mills, Ishara A, Selengut, Jeremy D, Parlikar, Beth E. W

“…Post-translational modifications provide sensitive and flexible mechanisms to dynamically modulate protein function in response to specific signalling inputs…”
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Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice by Latek, R R, Suri, A, Petzold, S J, Nelson, C A, Kanagawa, O, Unanue, E R, Fremont, D H

“…We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other…”
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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton by Dos D. Sarbassov, Ali, Siraj M, Kim, Do-Hyung, Guertin, David A, Latek, Robert R, Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M

“…The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby cells accumulate mass and…”
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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery by Kim, Do-Hyung, Sarbassov, Dos D., Ali, Siraj M., King, Jessie E., Latek, Robert R., Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M.

“…mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that…”
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The SANT domain: a unique histone-tail-binding module? by Peterson, Craig L, Boyer, Laurie A, Latek, Robert R

“…Chromatin-remodelling complexes have an important role in all DNA-mediated processes and, although much is known about how these enzymes regulate chromosomal…”
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GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR by Kim, Do-Hyung, Sarbassov, Dos D, Ali, Siraj M, Latek, Robert R, Guntur, Kalyani V.P, Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M

“…mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors. Here, we identify a…”
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Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-Ak class II molecules by Latek, R R, Petzold, S J, Unanue, E R

“…Selection of particular antigen-derived peptides by class II MHC molecules determines the population of complexes represented on the antigen-presenting cell…”
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Temperature-sensitive Yeast GPI Anchoring Mutants gpi2 and gpi3 Are Defective in the Synthesis of N-Acetylglucosaminyl Phosphatidylinositol by Leidich, Steven D., Kostova, Zlatka, Latek, Robert R., Costello, Lisa C., Drapp, Darren A., Gray, William, Fassler, Jan S., Orlean, Peter

“…To identify genes required for the synthesis of glycosyl phosphatidylinositol (GPI) membrane anchors in yeast, we devised a way to isolate GPI anchoring…”
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BCR-ABL Kinase Dynamics and Drug Resistance by Azam, Mohammad, Nardi, Valentina, Shakespear, William C., Latek, Robert R., Veach, Darren, Clarckson, Bernard, Bohacheck, Regine, Sawyer, Tomi K., Daley, George Q.

“…The aberrant signaling behavior caused by the expression of BCR-ABL is necessary and sufficient to cause chronic myeloid leukemia (CML), an observation which…”
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Mechanisms and consequences of peptide selection by the I‐A k class II molecule by Latek, Robert R., Unanue, Emil R.

“…Important quantitative parameters can be utilized to define the selection and the immunogenicity of protein antigens precisely at a biochemical and a cellijlar…”
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Temperature-sensitive yeast GPI anchoring mutants gpi2 and gpi3 are defective in the synthesis of N-acetylglucosaminyl phosphatidylinositol. Cloning of the GPI2 gene by Leidich, S D, Kostova, Z, Latek, R R, Costello, L C, Drapp, D A, Gray, W, Fassler, J S, Orlean, P

“…To identify genes required for the synthesis of glycosyl phosphatidylinositol (GPI) membrane anchors in yeast, we devised a way to isolate GPI anchoring…”
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Hindering Auxiliary Anchors Are Potent Modulators of Peptide Binding and Selection by I-AkClass II Molecules by Latek, Robert R., Petzold, Shirley J., Unanue, Emil R.

“…Selection of particular antigen-derived peptides by class II MHC molecules determines the population of complexes represented on the antigen-presenting cell…”
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Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-A k class II molecules by Latek, Robert R., Petzold, Shirley J., Unanue, Emil R.

“…Selection of particular antigen-derived peptides by class II MHC molecules determines the population of complexes represented on the antigen-presenting cell…”
Get full text

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR by Kim, Do-Hyung, Sarbassov, D D, Ali, Siraj M, Latek, Robert R, Guntur, Kalyani V P, Erdjument-Bromage, Hediye, Tempst, Paul, Sabatini, David M

“…mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors. Here, we identify a…”
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Mechanisms and consequences of peptide selection by the I-Ak class II molecule by Latek, Robert R., Unanue, Emil R.

“…Important quantitative parameters can be utilized to define the selection and the immunogenicity of protein antigens precisely at a biochemical and a cellijlar…”
Get full text