Search Results - "Lassus, Heini"

Risk of Gynecologic Cancer According to the Type of Endometriosis by Saavalainen, Liisu, Lassus, Heini, But, Anna, Tiitinen, Aila, Härkki, Päivi, Gissler, Mika, Pukkala, Eero, Heikinheimo, Oskari

“…OBJECTIVE:To assess the risks of gynecologic cancer according to the type of endometriosis in women with surgically verified endometriosis. METHODS:This is a…”
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Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers by Deng, Shan, Yang, Xiaojun, Lassus, Heini, Liang, Shun, Kaur, Sippy, Ye, Qunrui, Li, Chunsheng, Wang, Li-Ping, Roby, Katherine F, Orsulic, Sandra, Connolly, Denise C, Zhang, Youcheng, Montone, Kathleen, Bützow, Ralf, Coukos, George, Zhang, Lin

“…Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells. However, our knowledge of the expression and…”
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Incidence of extraovarian clear cell cancers in women with surgically diagnosed endometriosis: A cohort study by Saavalainen, Liisu, Lassus, Heini, But, Anna, Gissler, Mika, Heikinheimo, Oskari, Pukkala, Eero

“…Background Endometriosis is associated with increased risk of clear cell ovarian cancer and has even suggested being an etiological factor for this cancer…”
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MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer by NUO YANG, KAUR, Sippy, JOHNSTONE, Cameron N, CHEN, Xian-Ming, LIU, Chang-Gong, QIHONG HUANG, KATSAROS, Dionyssios, CALIN, George Adrian, WEBER, Barbara L, BÜTZOW, Ralf, CROCE, Carlo M, COUKOS, George, VOLINIA, Stefano, LIN ZHANG, GRESHOCK, Joel, LASSUS, Heini, HASEGAWA, Kosei, SHUN LIANG, LEMINEN, Arto, SHAN DENG, SMITH, Lori

“…MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that negatively regulate protein-coding gene expression in a sequence-specific manner via…”
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Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells by XIAOJUN YANG, XIAOJUAN LIN, XIA ZHAO, YOUCHENG ZHANG, BÜTZOW, Ralf, COUKOS, George, LIN ZHANG, XIAOMIN ZHONG, KAUR, Sippy, NING LI, SHUN LIANG, LASSUS, Heini, LIPING WANG, KATSAROS, Dionyssios, MONTONE, Kathleen

“…A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-like" subpopulation of tumor cells has the unique ability to initiate and perpetuate…”
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Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness by Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela

“…Glucocorticoids are routinely used in the clinic as anti-inflammatory and immunosuppressive agents as well as adjuvants during cancer treatment to mitigate the…”
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Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity by Santos, João Manuel, Heiniö, Camilla, Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Siurala, Mikko, Havunen, Riikka, Butzow, Ralf, Zafar, Sadia, de Gruijl, Tanja, Lassus, Heini, Kanerva, Anna, Hemminki, Akseli

“…BackgroundOvarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy…”
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Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma by Lassus, Heini, Staff, Synnöve, Leminen, Arto, Isola, Jorma, Butzow, Ralf

“…Abstract Objective Aurora-A is a potential oncogene and therapeutic target in ovarian carcinoma. It is involved in mitotic events and overexpression leads to…”
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A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer by NING LI, KAUR, Sippy, KATSAROS, Dionyssios, QIHONG HUANG, BÜTZOW, Ralf, WEBER, Barbara L, COUKOS, George, LIN ZHANG, GRESHOCK, Joel, LASSUS, Heini, XIAOMIN ZHONG, YANLING WANG, LEMINEN, Arto, ZHONGJUN SHAO, XIAOWEN HU, SHUN LIANG

“…Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a…”
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Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma by LASSUS, Heini, SIHTO, Harri, LEMINEN, Arto, JOENSUU, Heikki, ISOLA, Jorma, NUPPONEN, Nina N, BUTZOW, Ralf

“…EGFR and erbB-2 are targets for specific cancer therapy. The purpose of this study was to examine the frequency and clinicopathological correlations of gene…”
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Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients by Moilanen, Jarna, Lassus, Heini, Leminen, Arto, Vaheri, Antti, Bützow, Ralf, Carpén, Olli

“…Ezrin is a membrane–cytoskeleton linker protein, which regulates cell polarity and signaling. Increased ezrin expression in astrocytomas and uveal melanomas is…”
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Elevated Cyclooxygenase-2 Expression Is Associated with Altered Expression of p53 and SMAD4, Amplification of HER-2/neu, and Poor Outcome in Serous Ovarian Carcinoma by ERKINHEIMO, Tiina-Liisa, LASSUS, Heini, FINNE, Patrik, VAN REES, Bastiaan P, LEMINEN, Arto, YLIKORKALA, Olavi, HAGLUND, Caj, BUTZOW, Ralf, RISTIMÄKI, Ari

“…Purpose and Experimental Design: Cyclooxygenase-2 (COX-2) is frequently expressed in human adenocarcinomas and inhibition of COX-2 suppresses tumor formation…”
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Clinical factors and biomarker profiles associated with patient outcome in endometrioid ovarian carcinoma - Emphasis on tumor grade by Soovares, Piret, Pasanen, Annukka, Similä-Maarala, Jonna, Bützow, Ralf, Lassus, Heini

“…The role of clinicopathological factors and molecular markers in prognostic classification of endometrioid ovarian carcinoma (EnOC) is not established. Tumor…”
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TCGA molecular classification in endometriosis-associated ovarian carcinomas: Novel data on clear cell carcinoma by Similä-Maarala, Jonna, Soovares, Piret, Pasanen, Annukka, Ahvenainen, Terhi, Vahteristo, Pia, Bützow, Ralf, Lassus, Heini

“…Clear cell and endometrioid ovarian carcinomas (OCC and OEC, respectively) have a presumed origin in endometriosis and share molecular alterations with each…”
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L1CAM expression associates with poor outcome in endometrioid, but not in clear cell ovarian carcinoma by Soovares, Piret, Pasanen, Annukka, Bützow, Ralf, Lassus, Heini

“…Highlights • L1CAM predicts poor outcome in endometrioid, but not in clear cell ovarian carcinoma. • Our findings are similar to those previously observed in…”
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Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes by Pikkusaari, Sanna, Tumiati, Manuela, Virtanen, Anni, Oikkonen, Jaana, Li, Yilin, Perez-Villatoro, Fernando, Muranen, Taru, Salko, Matilda, Huhtinen, Kaisa, Kanerva, Anna, Koskela, Heidi, Tapper, Johanna, Koivisto-Korander, Riitta, Joutsiniemi, Titta, Haltia, Ulla-Maija, Lassus, Heini, Hautaniemi, Sampsa, Färkkilä, Anniina, Hynninen, Johanna, Hietanen, Sakari, Carpén, Olli, Kauppi, Liisa

“…Deficiency in homologous recombination (HR) repair of DNA damage is characteristic of many high-grade serous ovarian cancers (HGSC). It is imperative to…”
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Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance by Niskakoski, Anni, Pasanen, Annukka, Lassus, Heini, Renkonen-Sinisalo, Laura, Kaur, Sippy, Mecklin, Jukka-Pekka, Bützow, Ralf, Peltomäki, Päivi

“…Molecular alterations preceding endometrial and ovarian cancer and the sequence of events are unknown. Consecutive specimens from lifelong surveillance for…”
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Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma by Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli

“…Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment…”
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Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas by Niskakoski, Anni, Pasanen, Annukka, Porkka, Noora, Eldfors, Samuli, Lassus, Heini, Renkonen-Sinisalo, Laura, Kaur, Sippy, Mecklin, Jukka-Pekka, Bützow, Ralf, Peltomäki, Päivi

“…The diagnosis of carcinoma in both the uterus and the ovary simultaneously is not uncommon and raises the question of synchronous primaries vs. metastatic…”
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A Nationwide Cohort Study on the risk of non‐gynecological cancers in women with surgically verified endometriosis by Saavalainen, Liisu, Lassus, Heini, But, Anna, Tiitinen, Aila, Härkki, Päivi, Gissler, Mika, Heikinheimo, Oskari, Pukkala, Eero

“…We assessed the association of surgically verified endometriosis and risk of non‐gynecological cancers according to the type of endometriosis (i.e., ovarian,…”
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