Single nucleotide polymorphisms in genes of endothelin-1 and receptor A associated to cardiovascular in essential hypertension

The endothelin system, for its vasoconstrictor action, is related to the development of essential hypertension (HTAe). The polymorphism analysis of their genes represents a new approach to the study of this disease. We propose to analyze the interaction between stages of essential hypertension (HTAe...

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Bibliographic Details
Published in:	Hipertension y riesgo vascular Vol. 34; no. 2; p. 78
Main Authors:	Tamiozzo, S R, Lassen, O C, Herrera, J, Igarzabal, P, Tabares, S, Sembaj, A
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-04-2017
Subjects:	Aged Argentina - epidemiology Arrhythmias, Cardiac - etiology Cardiomegaly - etiology Endothelin-1 - genetics Endothelin-1 - physiology Essential Hypertension - complications Essential Hypertension - genetics Essential Hypertension - pathology Female Genetic Association Studies Heart - physiopathology Heart Rate Humans Male Middle Aged Myocardium - pathology Polymorphism, Single Nucleotide Receptor, Endothelin A - genetics Receptor, Endothelin A - physiology Risk Factors Severity of Illness Index Stroke Volume Argentina Essential hypertension Hipertensión arterial esencial Endotelina-1, Receptor A de endotelina-1 Endothelin-1, Receptor A of endothelin-1 Genetic polymorphisms Polimorfismos genéticos
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Summary:	The endothelin system, for its vasoconstrictor action, is related to the development of essential hypertension (HTAe). The polymorphism analysis of their genes represents a new approach to the study of this disease. We propose to analyze the interaction between stages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del A gene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA). We included 300 patients of both sexes, unrelated, who consecutively attended the clinic hypertension medical service. Each one underwent a complete physical examination, electrocardiogram, echocardiogram, and Rx thorax. The degree of severity of hypertension was determined in stages. The determination of polymorphisms was performed by amplification followed by cutting by specific restriction enzyme from DNA obtained from peripheral blood. The 46% of patients had HTAe controlled, 17.6% had organ damage or cardiovascular, brain or kidney disease. It was observed that the 4A/4A carriers showed lower frequency of cardiovascular disease, kidney and brain (P<.032; 95% CI: 11.1-21.4). For H323H polymorphism, the evaluation by images showed a higher frequency of the dilations of left auricular (P=.02) and auricular fibrillation (P=.03) between the T/T carrier, a higher frequency of cardiomegaly was detected in C/C patients (P=.04). The genotypes, 4A/4A of the ET-1 gene and the T/T from ETRA gene might be involved in worse outcome of cardiovascular damage. Their identification could help recognize subgroups of the hypertensive patients with different risk.
ISSN:	1989-4805
DOI:	10.1016/j.hipert.2016.10.003