Search Results - "Lassen, Kara G."

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome by Knights, Dan, Lassen, Kara G, Xavier, Ramnik J

“…Studies of the genetics underlying inflammatory bowel diseases have increased our understanding of the pathways involved in both ulcerative colitis and Crohn's…”
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Mechanisms and function of autophagy in intestinal disease by Lassen, Kara G., Xavier, Ramnik J.

“…The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that…”
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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense by Lassen, Kara G., Kuballa, Petric, Conway, Kara L., Patel, Khushbu K., Becker, Christine E., Peloquin, Joanna M., Villablanca, Eduardo J., Norman, Jason M., Liu, Ta-Chiang, Heath, Robert J., Becker, Morgan L., Fagbami, Lola, Horn, Heiko, Mercer, Johnathan, Yilmaz, Omer H., Jaffe, Jacob D., Shamji, Alykhan F., Bhan, Atul K., Carr, Steven A., Daly, Mark J., Virgin, Herbert W., Schreiber, Stuart L., Stappenbeck, Thaddeus S., Xavier, Ramnik J.

“…A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn…”
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Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk by Lassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R., Xavier, Ramnik J.

“…Although numerous polymorphisms have been associated with inflammatory bowel disease (IBD), identifying the function of these genetic factors has proved…”
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Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice by Ferder, Ianina C, Fung, Leslie, Ohguchi, Yasuyo, Zhang, Xiaoyu, Lassen, Kara G, Capen, Diane, Brown, Dennis, Xavier, Ramnik J, Wang, Ning

“…The transition from mitotic to meiotic cell cycles is essential for haploid gamete formation and fertility. Stimulated by retinoic acid gene 8 (Stra8) is an…”
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A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells by Selleck, Elizabeth M, Orchard, Robert C, Lassen, Kara G, Beatty, Wandy L, Xavier, Ramnik J, Levine, Beth, Virgin, Herbert W, Sibley, L David

“…A core set of autophagy proteins is required for gamma interferon (IFN-γ)-mediated clearance of Toxoplasma gondii in the mouse because of their control of…”
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The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response by Lavoie, Sydney, Conway, Kara L, Lassen, Kara G, Jijon, Humberto B, Pan, Hui, Chun, Eunyoung, Michaud, Monia, Lang, Jessica K, Gallini Comeau, Carey Ann, Dreyfuss, Jonathan M, Glickman, Jonathan N, Vlamakis, Hera, Ananthakrishnan, Ashwin, Kostic, Aleksander, Garrett, Wendy S, Xavier, Ramnik J

“…Inflammatory bowel disease (IBD) is driven by dysfunction between host genetics, the microbiota, and immune system. Knowledge gaps remain regarding how IBD…”
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RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy by Heath, Robert J., Goel, Gautam, Baxt, Leigh A., Rush, Jason S., Mohanan, Vishnu, Paulus, Geraldine L.C., Jani, Vijay, Lassen, Kara G., Xavier, Ramnik J.

“…Xenophagy is a form of selective autophagy that involves the targeting and elimination of intracellular pathogens through several recognition, recruitment, and…”
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A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs by Lassen, Kara G, Hebbeler, Andrew M, Bhattacharyya, Darshana, Lobritz, Michael A, Greene, Warner C

“…Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency have been generally hindered by the lack of a robust and rapidly…”
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Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 by Khor, Bernard, Conway, Kara L, Omar, Abdifatah S, Biton, Moshe, Haber, Adam L, Rogel, Noga, Baxt, Leigh A, Begun, Jakob, Kuballa, Petric, Gagnon, John D, Lassen, Kara G, Regev, Aviv, Xavier, Ramnik J

“…The clear role of autophagy in human inflammatory diseases such as Crohn disease was first identified by genome-wide association studies and subsequently…”
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Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics by Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.

“…Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity…”
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Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV by Chan, Jonathan K, Bhattacharyya, Darshana, Lassen, Kara G, Ruelas, Debbie, Greene, Warner C

“…Attempts to eradicate HIV have been thwarted by the persistence of a small pool of quiescent memory CD4 T cells that harbor a transcriptionally silent,…”
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Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1) by Sakane, Naoki, Kwon, Hye-Sook, Pagans, Sara, Kaehlcke, Katrin, Mizusawa, Yasuhiro, Kamada, Masafumi, Lassen, Kara G, Chan, Jonathan, Greene, Warner C, Schnoelzer, Martina, Ott, Melanie

“…The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are…”
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Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo by Murano, Tatsuro, Najibi, Mehran, Paulus, Geraldine L. C., Adiliaghdam, Fatemeh, Valencia-Guerrero, Aida, Selig, Martin, Wang, Xiaofei, Jeffrey, Kate, Xavier, Ramnik J., Lassen, Kara G., Irazoqui, Javier E.

“…Understanding the transcription factors that modulate epithelial resistance to injury is necessary for understanding intestinal homeostasis and injury repair…”
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Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy by Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A.B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca, Xavier, Ramnik J.

“…The polymorphism ATG16L1 T300A, associated with increased risk of Crohn’s disease, impairs pathogen defense mechanisms including selective autophagy, but…”
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Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells by Lassen, Kara G, Ramyar, Kasra X, Bailey, Justin R, Zhou, Yan, Siliciano, Robert F

“…HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe…”
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Neutralizing Antibodies Do Not Mediate Suppression of Human Immunodeficiency Virus Type 1 in Elite Suppressors or Selection of Plasma Virus Variants in Patients on Highly Active Antiretroviral Therapy by BAILEY, Justin R, LASSEN, Kara G, YANG, Hung-Chih, QUINN, Thomas C, RAY, Stuart C, BLANKSON, Joel N, SILICIANO, Robert F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules by Shaw, Stanley Y, Tran, Khoa, Castoreno, Adam B, Peloquin, Joanna M, Lassen, Kara G, Khor, Bernard, Aldrich, Leslie N, Tan, Pauline H, Graham, Daniel B, Kuballa, Petric, Goel, Gautam, Daly, Mark J, Shamji, Alykhan F, Schreiber, Stuart L, Xavier, Ramnik J

“…Autophagy is an evolutionarily conserved catabolic process that directs cytoplasmic proteins, organelles and microbes to lysosomes for degradation. Autophagy…”
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Analysis of Human Immunodeficiency Virus Type 1 Transcriptional Elongation in Resting CD4+ T Cells In Vivo by LASSEN, Kara G, BAILEY, Justin R, SILICIANO, Robert F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse by Liao, Juan, Jijon, Humberto B, Kim, Ira R, Goel, Gautam, Doan, Aivi, Sokol, Harry, Bauer, Hermann, Herrmann, Bernhard G, Lassen, Kara G, Xavier, Ramnik J

“…The pathogenesis of complex diseases, such as type 1 diabetes (T1D), derives from interactions between host genetics and environmental factors. Previous…”
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