Search Results - "Lassam, N."

MLK‐3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6 by Tibbles, L. A., Ing, Y. L., Kiefer, F., Chan, J., Iscove, N., Woodgett, J. R., Lassam, N. J.

“…Mixed lineage kinase‐3 (MLK‐3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function…”
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CDKN2A Mutations in Multiple Primary Melanomas by Monzon, Jose, Liu, Ling, Brill, Herbert, Goldstein, Alisa M, Tucker, Margaret A, From, Lynn, McLaughlin, John, Hogg, David, Lassam, Norman J

“…Some patients with cancer have one or more subsequent primary tumors of the same histologic subtype. This phenomenon can be explained by the long-term exposure…”
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Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-Aza-2'-deoxycytidine by WEBER, J, SALGALLER, M, SAMID, D, JOHNSON, B, HERLYN, M, LASSAM, N, TREISMAN, J, ROSENBERG, S. A

“…MAGE-1 is a gene that encodes an antigen on a melanoma cell line that is recognized by cytolytic T-cells. We have used a reverse transcription-polymerase chain…”
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Overexpression of p53 is a late event in the development of malignant melanoma by LASSAM, N. J, FROM, L, KAHN, H. J

“…Overexpression of the p53 gene product has been observed in a high percentage of malignant melanomas. To evaluate the role of this protein in the development…”
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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway by Kiefer, F., Tibbles, L. A., Anafi, M., Janssen, A., Zanke, B. W., Lassam, N., Pawson, T., Woodgett, J. R., Iscove, N. N.

“…In mammalian cells, a specific stress‐activated protein kinase (SAPK/JNK) pathway is activated in response to inflammatory cytokines, injury from heat,…”
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Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma : results of a phase 1 clinical trial by STEWART, A. K, LASSAM, N. J, ADDISON, C. L, MOEN, R. C, GAULDIE, T, GRAHAM, F. L, QUIRT, I. C, BAILEY, D. J, ROTSTEIN, L. E, KRAJDEN, M, DESSUREAULT, S, GALLINGER, S, CAPPE, D, WAN, Y

“…We conducted a phase 1 trial of direct injection of an E1, E3-deleted adenovirus encoding interleukin-2 (AdCAIL-2) into subcutaneous deposits of melanoma or…”
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Loss of c-kit expression in cultured melanoma cells by Lassam, N, Bickford, S

“…The proto-oncogene c-kit encodes a receptor tyrosine kinase which has been shown to play a key role in melanocyte development. In this report we asked whether…”
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CDKN2A mutation in a non‐FAMMM kindred with cancers at multiple sites results in a functionally abnormal protein by Sun, Sophie, Pollock, Pamela M., Liu, Ling, Karimi, Sepideh, Jothy, Serge, Milner, Benedict J., Renwick, Andrew, Lassam, Norman J., Hayward, Nicholas K., Hogg, David, Narod, Steven A., Foulkes, William D.

“…The CDKN2A gene encodes p16 (CDKN2A), a cell‐cycle inhibitor protein which prevents inappropriate cell cycling and, hence, proliferation. Germ‐line mutations…”
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MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain by Ing, Y L, Leung, I W, Heng, H H, Tsui, L C, Lassam, N J

“…We have identified a novel protein kinase, designated MLK-3, from human thymus using RT-PCR and cDNA library screening. The deduced open reading frame, derived…”
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Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation by Lassam, N, Jay, G

“…The oncogenic potential of some transformed cell lines has been shown in animal tumor models to be the direct result of MHC class I mRNA suppression. Rodent…”
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Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations by Lal, Geeta, Liu, Ling, Hogg, David, Lassam, Norman J., Redston, Mark S., Gallinger, Steven

“…Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second…”
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Fine mapping of the MLK-3 gene within 11q13 and its exclusion as the MEN1 susceptibility gene by LASSAM, N. J, LIN, Z, SHENNAN, M. G, COURSEAUX, A, TEH, B. T, GAUDRAY, P, LARSSON, C

“…MLK-3 kinase is a widely expressed serine/ threonine kinase that bears multiple protein interaction domains and regulates signals mediated by the…”
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A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma by Stewart, A K, Lassam, N J, Graham, F L, Gauldie, J, Addison, C L, Bailey, D J, Dessureault, S, Dubé, I D, Gallenger, S, Krajden, M, Rotstein, L E, Quirt, I C, Moen, R

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Protein kinases in normal and transformed melanocytes by Quong, R Y, Bickford, S T, Ing, Y L, Terman, B, Herlyn, M, Lassam, N J

“…Aberrant function of protein kinases has been implicated in the development of melanoma. In an effort to define the molecular events involved in initiation and…”
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The mouse homologs of RELA and MLK3 are located within a 120-kb fragment on chromosome 19 by Fernandes, M, Poirier, C, Lassam, N J, Larsson, C, Guénet, J, Gaudray, P, Carle, G F

“…Recent advances in the identification of a large collection of polymorphic genetic markers and unique probes have yielded respectively detailed genetic and…”
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Novel components of mammalian stress-activated protein kinase cascades by Kiefer, F, Tibbles, L A, Lassam, N, Zanke, B, Iscove, N, Woodgett, J R

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Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma by Hogg, D, Brill, H, Liu, L, Monzon, J, Summers, A, From, L, Lassam, N J

“…Approximately 8 to 12% of melanoma appears to be inherited in an autosomal dominant form. Although most early stage melanomas can be treated successfully by…”
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Lack of germ-line mutations of CDK4, p16INK4A, and p15INK4B in families with glioma by GAO, L, LIU, L, VAN MEYEL, D, CAIRNCROSS, G, FORSYTH, P, KIMMEL, D, JENKINS, R. B, LASSAM, N. J, HOGG, D

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VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor by Terman, B, Khandke, L, Dougher-Vermazan, M, Maglione, D, Lassam, N J, Gospodarowicz, D, Persico, M G, Böhlen, P, Eisinger, M

“…Vascular endothelial growth factor (VEGF) is an angiogenic growth factor which binds to two structurally related tyrosine kinase receptors denoted KDR and…”
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Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma by Hogg, David, Liu, Ling, Dilworth, David, Gao, Luzhang, Monzon, Jose, Summers, Ann, Lassam, Norman

“…Approximately 8-12% of melanoma is inherited in an autosomal dominant fashion with variable penetrance. A chromosome 9p21 locus has been linked to this disease…”
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