Search Results - "Lassagne, Frederic"

Lateral Deprotometallation‐Trapping Reactions on Methylated Pyridines, Quinolines and Quinoxalines Using Lithium Diethylamide by Hasyeoui, Mohamed, Chapple, Peter M., Lassagne, Frédéric, Roisnel, Thierry, Cordier, Marie, Samarat, Ali, Sarazin, Yann, Mongin, Florence

“…The functionalization of methylated azines and diazines has aroused the interest of chemists given the structural diversity that it affords. Hindered lithium…”
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Deprotonative Metalation of Methoxy-Substituted Arenes Using Lithium 2,2,6,6-Tetramethylpiperidide: Experimental and Computational Study by Akimoto, Gaku, Otsuka, Mai, Takita, Ryo, Uchiyama, Masanobu, Hedidi, Madani, Bentabed-Ababsa, Ghenia, Lassagne, Frédéric, Erb, William, Mongin, Florence

“…The reaction pathways of lithium 2,2,6,6-tetramethylpiperidide (LiTMP)-mediated deprotonative metalation of methoxy-substituted arenes were investigated…”
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Thiazolo[5,4‐f]quinoxalines, Oxazolo[5,4‐f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6‐Aminoquinoxalines and Properties by Lassagne, Frédéric, Sims, Joshua M., Erb, William, Mongin, Olivier, Richy, Nicolas, El Osmani, Nour, Fajloun, Ziad, Picot, Laurent, Thiéry, Valérie, Robert, Thomas, Bach, Stéphane, Dorcet, Vincent, Roisnel, Thierry, Mongin, Florence

“…The regioselective iodination of different 2‐mono‐, 3‐mono‐ and 2,3‐disubstituted 6‐aminoquinoxalines, which takes place at their 5‐position, was rationalized…”
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From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3) by Lassagne, Frédéric, Duguépéroux, Camille, Roca, Carlos, Perez, Concepcion, Martinez, Ana, Baratte, Blandine, Robert, Thomas, Ruchaud, Sandrine, Bach, Stéphane, Erb, William, Roisnel, Thierry, Mongin, Florence

“…2,7-Disubstituted oxazolo[5,4-f]quinoxalines were synthesized from 6-amino-2-chloroquinoxaline in four steps (iodination at C5, substitution of the chloro…”
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Aromatic Iodides: Synthesis and Conversion to Heterocycles by Mongin, Florence, Erb, William, Lassagne, Frédéric

“…Aromatic heterocycles can be found in many molecules endowed with specific properties, in particular for applications in the fields of medicinal chemistry and…”
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Copper‐ and Cobalt‐Catalyzed Syntheses of Thiophene‐Based Tertiary Amines by Bouarfa, Salima, Graßl, Simon, Ivanova, Maria, Langlais, Timothy, Bentabed‐Ababsa, Ghenia, Lassagne, Frédéric, Erb, William, Roisnel, Thierry, Dorcet, Vincent, Knochel, Paul, Mongin, Florence

“…Thienylzinc halides and related compounds prepared by deprotonation followed by transmetalation were used in copper‐catalyzed amination using N‐benzoyloxy…”
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Conversion of Isatins to Tryptanthrins, Heterocycles Endowed with a Myriad of Bioactivities by Amara, Rim, Awad, Haçan, Chaker, Diana, Bentabed‐Ababsa, Ghenia, Lassagne, Frédéric, Erb, William, Chevallier, Floris, Roisnel, Thierry, Dorcet, Vincent, Fajloun, Ziad, Vidal, Joëlle, Mongin, Florence

“…The numerous bioactivities exhibited by tryptanthrins led chemists to develop synthetic approaches towards this important scaffold. In particular, conversion…”
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Fused Systems Based on 2‐Aminopyrimidines: Synthesis Combining Deprotolithiation‐in situ Zincation with N‐Arylation Reactions and Biological Properties by Hedidi, Madani, Maillard, Julien, Erb, William, Lassagne, Frédéric, Halauko, Yury S., Ivashkevich, Oleg A., Matulis, Vadim E., Roisnel, Thierry, Dorcet, Vincent, Hamzé, Monzer, Fajloun, Ziad, Baratte, Blandine, Ruchaud, Sandrine, Bach, Stéphane, Bentabed‐Ababsa, Ghenia, Mongin, Florence

“…Various aromatic ketones were first functionalized next to the carbonyl function by deprotolithiation in the presence of a zinc salt followed by iodolysis. The…”
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From Quinoxaline, Pyrido[2,3- b ]pyrazine and Pyrido[3,4- b ]pyrazine to Pyrazino-Fused Carbazoles and Carbolines by Lassagne, Frédéric, Langlais, Timothy, Caytan, Elsa, Limanton, Emmanuelle, Paquin, Ludovic, Boullard, Manon, Courtel, Coline, Curbet, Idriss, Gédéon, Clément, Lebreton, Julien, Picot, Laurent, Thiéry, Valérie, Souab, Mohamed, Baratte, Blandine, Ruchaud, Sandrine, Bach, Stéphane, Roisnel, Thierry, Mongin, Florence

“…2,3-Diphenylated quinoxaline, pyrido[2,3- ]pyrazine and 8-bromopyrido[3,4- ]pyrazine were halogenated in deprotometalation-trapping reactions using mixed…”
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Saccharin as an Organocatalyst for Quinoxalines and Pyrido[2,3-b]pyrazines Syntheses by Lassagne, Frédéric, Chevallier, Floris, Mongin, Florence

“…A room-temperature procedure using saccharin as catalyst has been described for the cyclocondensation of different 1,2-arylenediamines with various…”
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Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells by Hasyeoui, Mohamed, Lassagne, Frédéric, Erb, William, Nael, Manal, Elokely, Khaled M., Chaikuad, Apirat, Knapp, Stefan, Jorda, Adrian, Vallés, Soraya L., Quissac, Emie, Verreault, Maïté, Robert, Thomas, Bach, Stéphane, Samarat, Ali, Mongin, Florence

“…[Display omitted] The 2-(3-pyridyl)oxazolo[5,4-f]quinoxalines CD-07 and FL-291 are ATP-competitive GSK-3 kinase inhibitors. Here, we investigated the impact of…”
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Deproto-metallation and computed CH acidity of 2-aryl-1,2,3-triazoles by Chevallier, Floris, Blin, Thomas, Nagaradja, Elisabeth, Lassagne, Frédéric, Roisnel, Thierry, Halauko, Yury S, Matulis, Vadim E, Ivashkevich, Oleg A, Mongin, Florence

“…2-Aryl-1,2,3-triazoles were synthesized by cyclization of the corresponding glyoxal arylosazones, generated from commercial arylhydrazines. The…”
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Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives by Snégaroff, Katia, Lassagne, Frédéric, Bentabed-Ababsa, Ghenia, Nassar, Ekhlass, Ely, Sidaty Cheikh Sid, Hesse, Stéphanie, Perspicace, Enrico, Derdour, Aïcha, Mongin, Florence

“…A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the…”
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New Approach to 3-Aminothiophene- 2-carboxylic Acid Derivatives: Access to 5-Aryl-4-(ethylsulfanyl) Compounds by Lassagne, Frédéric, Pochat, Francis, Sinbandhit, Sourisak

“…Treatment of DMSO/water solutions of β-bromo-α-(ethylsulfanyl)cinnamonitriles with sodium sulphide and α-halo acetic acids derivatives followed by cyclization…”
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Thiazoloquinoxalines, Oxazoloquinoxalines and Pyrazinoisatins: Synthesis from 6‐Aminoquinoxalines and Properties by Lassagne, Frédéric, Sims, Joshua M, Erb, William, Mongin, Olivier, Richy, Nicolas, Nour El Osmani, Fajloun, Ziad, Picot, Laurent, Thiéry, Valérie, Thomas, Robert, Bach, Stéphane, Dorcet, Vincent, Roisnel, Thierry, Mongin, Florence

“…The regioselective iodination of different 2‐mono‐, 3‐mono‐ and 2,3‐disubstituted 6‐aminoquinoxalines, which takes place at their 5‐position, was rationalized…”
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Synthesis of 3-Cyanoflavones and Their Biological Evaluation by M. Gaydou, Emile, Lassagne, Frederic, Bombarda, Isabelle, Dherbomez, Michel, Sinbandhit, Sourisak

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Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells by Hedidi, Madani, Maillard, Julien, Erb, William, Lassagne, Frédéric, Halauko, Yury, Ivashkevich, Oleg, Matulis, Vadim, Roisnel, Thierry, Dorcet, Vincent, Hamzé, Monzer, Fajloun, Ziad, Baratte, Blandine, Ruchaud, Sandrine, Bach, Stéphane, Bentabed-Ababsa, Ghenia, Mongin, Florence

“…N-Arylation of pyrrole with 3-iodo-4-methoxypyridine was investigated by copper catalysis under different conditions. The best conditions, that proved to be…”
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A convenient access to 3-cyanoflavones by Lassagne, Frédéric, Pochat, Francis

“…Reaction of β-bromo α-alkylthiocinnamonitriles with various substituted methyl salicylates followed by treatment with AlCl 3/PhNO 2 provides 3-cyanoflavones…”
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Aza-β3-Cyclohexapeptides:  Pseudopeptidic Macrocycles with Interesting Conformational and Configurational Properties Slow Pyramidal Nitrogen Inversion in 24-Membered Rings by Le Grel, Philippe, Salaün, Arnaud, Potel, Michel, Le Grel, Barbara, Lassagne, Fredéric

“…Among pseudopeptidic foldamers, aza-β3-peptides have the unique property to possess nitrogen stereocenters instead of carbon stereocenters. As the result of…”
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Aza-β 3 -Cyclohexapeptides:  Pseudopeptidic Macrocycles with Interesting Conformational and Configurational Properties Slow Pyramidal Nitrogen Inversion in 24-Membered Rings by Le Grel, Philippe, Salaün, Arnaud, Potel, Michel, Le Grel, Barbara, Lassagne, Fredéric

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