Search Results - "Lassé, Moritz"

Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals by Lassé, Moritz, Pilbrow, Anna P., Kleffmann, Torsten, Andersson Överström, Elin, von Zychlinski, Anne, Frampton, Christopher M. A., Poppe, Katrina K., Troughton, Richard W., Lewis, Lynley K., Prickett, Timothy C. R., Pemberton, Christopher J., Richards, Arthur M., Cameron, Vicky A.

“…To identify circulating proteins predictive of acute cardiovascular disease events in the general population, we performed a proteomic screen in plasma from…”
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Evaluation of protease resistance and toxicity of amyloid-like food fibrils from whey, soy, kidney bean, and egg white by Lassé, Moritz, Ulluwishewa, Dulantha, Healy, Jackie, Thompson, Dion, Miller, Antonia, Roy, Nicole, Chitcholtan, Kenny, Gerrard, Juliet A.

“…•Food fibrils were non-toxic to Caco-2 and Hec-1a cell lines in vitro.•Native protein and fibrillar protein had similar effects on cell viability.•Fibrils…”
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Proteolysis and inflammation of the kidney glomerulus by Demir, Fatih, Troldborg, Anne, Thiel, Steffen, Lassé, Moritz, Huesgen, Pitter F., Tomas, Nicola M., Wiech, Thorsten, Rinschen, Markus M.

“…Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of…”
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Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy by Reinhard, Linda, Machalitza, Maya, Wiech, Thorsten, Gröne, Hermann-Josef, Lassé, Moritz, Rinschen, Markus M, Ferru, Nicoletta, Bräsen, Jan Hinrich, Drömann, Friederike, Rob, Peter Maria, Sethi, Sanjeev, Hoxha, Elion, Stahl, Rolf A K

“…Primary membranous nephropathy (MN) is caused by circulating autoantibodies binding to antigens on the podocyte surface. PLA R1 is the main target antigen in…”
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High Salt Remodels Kidney Metabolism: Metabolite Fuel, Fate, and Signals by Lassé, Moritz, Rinschen, Markus M

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Metabolic Communication by SGLT2 Inhibition by Billing, Anja M, Kim, Young Chul, Gullaksen, Søren, Schrage, Benedikt, Raabe, Janice, Hutzfeldt, Arvid, Demir, Fatih, Kovalenko, Elina, Lassé, Moritz, Dugourd, Aurelien, Fallegger, Robin, Klampe, Birgit, Jaegers, Johannes, Li, Qing, Kravtsova, Olha, Crespo-Masip, Maria, Palermo, Amelia, Fenton, Robert A, Hoxha, Elion, Blankenberg, Stefan, Kirchhof, Paulus, Huber, Tobias B, Laugesen, Esben, Zeller, Tanja, Chrysopolou, Maria, Saez-Rodriguez, Julio, Magnussen, Christina, Eschenhagen, Thomas, Staruschenko, Alexander, Siuzdak, Gary, Poulsen, Per L, Schwab, Clarissa, Cuello, Friederike, Vallon, Volker, Rinschen, Markus M

“…SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but the underlying mechanism remains poorly understood. To gain…”
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The impact of pH, salt concentration and heat on digestibility and amino acid modification in egg white protein by Lassé, Moritz, Deb-Choudhury, Santanu, Haines, Stephen, Larsen, Nigel, Gerrard, Juliet A., Dyer, Jolon M.

“…•Heating improves egg white digestibility at the cost of amino acid modifications.•Heating increases amino acid oxidation, nitration, deamidation, and…”
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Pathogenicity of Human Anti-PLA2R1 Antibodies in Minipigs: A Pilot Study by Reinhard, Linda, Wiech, Thorsten, Reitmeier, Aline, Lassé, Moritz, Machalitza, Maya, Heumann, Asmus, Ferru, Nicoletta, Loreth, Desiree, Schröder, Marie-Luise, Hutzfeldt, Arvid, Stahl, Felix R., Peine, Sven, Gröne, Hermann-Josef, Meyer-Schwesinger, Catherine, Rinschen, Markus M., Stahl, Rolf A.K., Hoxha, Elion

“…Significance Statement Membranous nephropathy (MN) is an autoimmune kidney disease characterized by immune deposits in the glomerular basement membrane…”
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Autoantibodies Targeting Nephrin in Podocytopathies by Hengel, Felicitas E., Dehde, Silke, Lassé, Moritz, Zahner, Gunther, Seifert, Larissa, Schnarre, Annabel, Kretz, Oliver, Demir, Fatih, Pinnschmidt, Hans O., Grahammer, Florian, Lucas, Renke, Mehner, Lea Maxima, Zimmermann, Tom, Billing, Anja M., Oh, Jun, Mitrotti, Adele, Pontrelli, Paola, Debiec, Hanna, Dossier, Claire, Colucci, Manuela, Emma, Francesco, Smoyer, William E., Weins, Astrid, Schaefer, Franz, Alachkar, Nada, Diemert, Anke, Hogan, Julien, Hoxha, Elion, Wiech, Thorsten, Rinschen, Markus M., Ronco, Pierre, Vivarelli, Marina, Gesualdo, Loreto, Tomas, Nicola M., Huber, Tobias B.

“…Antinephrin autoantibodies occur in adults with minimal change disease and children with idiopathic nephrotic syndrome and appear to be disease activity…”
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Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1 -/- ) gain less body weight during adolescence and adulthood by Dumoulin, Bernhard, Heydeck, Dagmar, Jähn, Desiree, Lassé, Moritz, Sofi, Sajad, Ufer, Christoph, Kuhn, Hartmut

“…The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that…”
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Comparison of SPEED, S-Trap, and In-Solution-Based Sample Preparation Methods for Mass Spectrometry in Kidney Tissue and Plasma by Templeton, Evelyn M, Pilbrow, Anna P, Kleffmann, Torsten, Pickering, John W, Rademaker, Miriam T, Scott, Nicola J A, Ellmers, Leigh J, Charles, Christopher J, Endre, Zoltan H, Richards, A Mark, Cameron, Vicky A, Lassé, Moritz

“…Mass spectrometry is a powerful technique for investigating renal pathologies and identifying biomarkers, and efficient protein extraction from kidney tissue…”
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Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure by Templeton, Evelyn M, Lassé, Moritz, Kleffmann, Torsten, Ellmers, Leigh J, Palmer, Suetonia C, Davidson, Trent, Scott, Nicola J A, Pickering, John W, Charles, Christopher J, Endre, Zoltan H, Cameron, Vicky A, Richards, A Mark, Rademaker, Miriam T, Pilbrow, Anna P

“…One-quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI)-an abrupt reduction or loss of kidney function…”
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An integrated organoid omics map extends modeling potential of kidney disease by Lassé, Moritz, El Saghir, Jamal, Berthier, Celine C., Eddy, Sean, Fischer, Matthew, Laufer, Sandra D., Kylies, Dominik, Hutzfeldt, Arvid, Bonin, Léna Lydie, Dumoulin, Bernhard, Menon, Rajasree, Vega-Warner, Virginia, Eichinger, Felix, Alakwaa, Fadhl, Fermin, Damian, Billing, Anja M., Minakawa, Akihiro, McCown, Phillip J., Rose, Michael P., Godfrey, Bradley, Meister, Elisabeth, Wiech, Thorsten, Noriega, Mercedes, Chrysopoulou, Maria, Brandts, Paul, Ju, Wenjun, Reinhard, Linda, Hoxha, Elion, Grahammer, Florian, Lindenmeyer, Maja T., Huber, Tobias B., Schlüter, Hartmut, Thiel, Steffen, Mariani, Laura H., Puelles, Victor G., Braun, Fabian, Kretzler, Matthias, Demir, Fatih, Harder, Jennifer L., Rinschen, Markus M.

“…Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression…”
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Reaction dynamics and residue identification of haemoglobin modification by acrolein, a lipid-peroxidation by-product by Lassé, Moritz, Stampfli, Anja R., Orban, Thomas, Bothara, Roshit K., Gerrard, Juliet A., Fairbanks, Antony J., Pattinson, Neil R., Dobson, Renwick C.J.

“…Abstract Lipid hydroperoxides decompose to reactive aldehydes, such as acrolein. Measurement of oxidative stress markers in the clinic could improve risk…”
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Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations by Wu, Zhenqiang, Pilbrow, Anna P., Liew, Oi Wah, Chong, Jenny P.C., Sluyter, John, Lewis, Lynley K., Lasse, Moritz, Frampton, Chris M., Jackson, Rod, Poppe, Katrina, Camargo, Carlos Arturo, Cameron, Vicky A., Scragg, Robert, Richards, A. Mark

“…Plasma cardiac markers may assist in prediction of incident cardiovascular disease. The incremental value of cardiac Troponins (T and I) and NT-proBNP added to…”
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Stability and cytotoxicity of crystallin amyloid nanofibrils by Kaur, Manmeet, Healy, Jackie, Vasudevamurthy, Madhusudan, Lassé, Moritz, Puskar, Ljiljana, Tobin, Mark J, Valery, Celine, Gerrard, Juliet A, Sasso, Luigi

“…Previous work has identified crystallin proteins extracted from fish eye lenses as a cheap and readily available source for the self-assembly of amyloid…”
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Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery by Poen, Sinothai, Nakatani, Yoshio, Opel-Reading, Helen K, Lassé, Moritz, Dobson, Renwick C J, Krause, Kurt L

“…Glutamate racemase (MurI) is responsible for providing D-glutamate for peptidoglycan biosynthesis in bacteria and has been a favoured target in pharmaceutical…”
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Consensus Draft of the Mouse Podocyte-Ome: FR-PO712 by Hutzfeldt, Arvid D., Tan, Yifan, Bonin, Léna L., Lassé, Moritz, Demir, Fatih, Rinschen, Markus M.

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An Integrated Proteome-Transcriptome Organoid Atlas Illuminates Core Concepts of Kidney Disease: TH-PO541 by Lassé, Moritz, El Saghir, Jamal, Berthier, Celine C., Eddy, Sean, Fischer, Matthew, Kretzler, Matthias, Harder, Jennifer L., Rinschen, Markus M.

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TNF-Treated Kidney Organoids Recapitulate Poor Outcome Nephrotic Syndrome: TH-PO441 by Fischer, Matthew, Lassé, Moritz, Eddy, Sean, El Saghir, Jamal, Vega-Warner, V., Kretzler, Matthias, Rinschen, Markus M., Harder, Jennifer L.

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