Search Results - "Lason, Wladyslaw"

Emerging Molecular Targets for Anti-Epileptogenic and Epilepsy Modifying Drugs by Łukasiuk, Katarzyna, Lasoń, Władysław

“…The pharmacological treatment of epilepsy is purely symptomatic. Despite many decades of intensive research, causal treatment of this common neurologic…”
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Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage by Jantas, Danuta, Warszyński, Piotr, Lasoń, Władysław

“…This study compared the neuroprotective efficacy of three antioxidants-the plant-derived carnosic acid (CA), and two synthetic free radical scavengers:…”
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Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials by Kryst, Joanna, Kawalec, Paweł, Mitoraj, Alicja Mikrut, Pilc, Andrzej, Lasoń, Władysław, Brzostek, Tomasz

“…Due to unmet clinical needs for efficient drugs with a rapid onset of antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in…”
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Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications by Jantas, Danuta, Lasoń, Władysław

“…Neurodegenerative diseases are the most frequent chronic, age-associated neurological pathologies having a major impact on the patient’s quality of life…”
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Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress–Induced Cell Damage: an Involvement of Cathepsin D Inhibition by Jantas, Danuta, Chwastek, Jakub, Grygier, Beata, Lasoń, Władysław

“…Necroptosis, a recently discovered form of non-apoptotic programmed cell death, can be implicated in many pathological conditions including neuronal cell…”
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Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons by Wnuk, Agnieszka, Rzemieniec, Joanna, Litwa, Ewa, Lasoń, Władysław, Kajta, Małgorzata

“…[Display omitted] •Prenatal exposure to BP-3 induces apoptosis in neocortical neurons of offspring.•BP-3 decreases ESR1/ESR2 expression and increases GPER1…”
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Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures by Ślusarczyk, Joanna, Trojan, Ewa, Głombik, Katarzyna, Piotrowska, Anna, Budziszewska, Bogusława, Kubera, Marta, Popiołek-Barczyk, Katarzyna, Lasoń, Władysław, Mika, Joanna, Basta-Kaim, Agnieszka

“…An increasing body of evidence postulates that microglia are the main mediators of inflammation-related disorders, including depression. Since activated…”
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The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D by Chwastek, Jakub, Jantas, Danuta, Lasoń, Władysław

“…[Display omitted] •KU-55933 provided neuroprotection against H2O2- and doxorubicin (Dox)- but not staurosporine (St)-induced cell damage.•KU-55933 mediated…”
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The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer's and Parkinson's Diseases: A Narrative Review by Lasoń, Władysław, Jantas, Danuta, Leśkiewicz, Monika, Regulska, Magdalena, Basta-Kaim, Agnieszka

“…The vitamin D receptor (VDR) belongs to the nuclear receptor superfamily of transcription factors. The VDR is expressed in diverse brain regions and has been…”
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Antiepileptic drugs and adverse skin reactions: An update by Błaszczyk, Barbara, Lasoń, Władysław, Czuczwar, Stanisław Jerzy

“…This paper summarizes current views on clinical manifestation, pathogenesis, prognosis and management of antiepileptic drug (AED)-induced adverse skin…”
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Prenatal Exposure to Benzophenone-3 Impairs Autophagy, Disrupts RXRs/PPARγ Signaling, and Alters Epigenetic and Post-Translational Statuses in Brain Neurons by Wnuk, Agnieszka, Rzemieniec, Joanna, Staroń, Jakub, Litwa, Ewa, Lasoń, Władysław, Bojarski, Andrzej, Kajta, Małgorzata

“…The UV absorber benzophenone-3 (BP-3) is the most extensively used chemical substance in various personal care products. Despite that BP-3 exposure is…”
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Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells by Wnuk, Agnieszka, Rzemieniec, Joanna, Lasoń, Władysław, Krzeptowski, Wojciech, Kajta, Małgorzata

“…Benzophenone-3 (BP-3) is the most widely used compound among UV filters for the prevention of photodegradation. Population studies have demonstrated that it…”
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Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease by Trojan, Ewa, Curzytek, Katarzyna, Cieślik, Paulina, Wierońska, Joanna M., Graff, Johannes, Lasoń, Władysław, Saito, Takashi, Saido, Takaomi C., Basta-Kaim, Agnieszka

“…Accumulating evidence indicates that early adverse life experiences may be involved in the pathogenesis of Alzheimer's disease (AD). Prenatal stress (PS) can…”
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New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection by Jantas, Danuta, Lech, Tomasz, Gołda, Sławomir, Pilc, Andrzej, Lasoń, Władysław

“…A specific activation of metabotropic glutamate receptor 7 (mGluR7) has been shown to be neuroprotective in various models of neuronal cell damage, however,…”
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Vitamin D3 and Ischemic Stroke: A Narrative Review by Lasoń, Władysław, Jantas, Danuta, Leśkiewicz, Monika, Regulska, Magdalena, Basta-Kaim, Agnieszka

“…Ischemic stroke is one of the major causes of death and permanent disability worldwide. The only efficient treatment to date is anticoagulant therapy and…”
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Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression by Anderson, George, Kubera, Marta, Duda, Weronika, Lasoń, Władysław, Berk, Michael, Maes, Michael

“…Depression has been conceptualized as a disorder driven by immuno-inflammatory pathways and oxidative and nitrosative stress. These factors couple to the…”
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Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic‐Induced Human Neuroblastoma SH‐SY5Y Cell Damage: The Impact of Cell Differentiation State by Jantas, Danuta, Grygier, Beata, Zatorska, Justyna, Lasoń, Władysław

“…The participation of group III metabotropic glutamate receptors (mGluRs) in cancer growth and progression is still an understudied issue. Based on our recent…”
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Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats by Głombik, Katarzyna, Stachowicz, Aneta, Ślusarczyk, Joanna, Trojan, Ewa, Budziszewska, Bogusława, Suski, Maciej, Kubera, Marta, Lasoń, Władysław, Wędzony, Krzysztof, Olszanecki, Rafał, Basta-Kaim, Agnieszka

“…Highlights • Prenatal stress leads to behavioral disturbances. • Prenatal stress supresses mitochondrial biogenesis. • Prenatal stress affects the expresssion…”
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Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells by Ślusarczyk, Joanna, Trojan, Ewa, Głombik, Katarzyna, Budziszewska, Bogusława, Kubera, Marta, Lasoń, Władysław, Popiołek-Barczyk, Katarzyna, Mika, Joanna, Wędzony, Krzysztof, Basta-Kaim, Agnieszka

“…Several lines of evidence suggest that the dysregulation of the immune system is an important factor in the development of depression. Microglia are the…”
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Developments in the discovery and design of intranasal antidepressants by Panek, Małgorzata, Kawalec, Paweł, Pilc, Andrzej, Lasoń, Władysław

“…Depression remains a major cause of morbidity worldwide; consequently, there is a need in neuropsychiatry for new antidepressants with a rapid onset of action…”
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