Search Results - "Lasky‐Su, J"

Plasma metabolite profiles in children with current asthma by Kelly, R. S., Sordillo, J. E., Lasky‐Su, J., Dahlin, A., Perng, W., Rifas‐Shiman, S. L., Weiss, S. T., Gold, D. R., Litonjua, A. A., Hivert, M.‐F., Oken, E., Wu, A. C.

“…Summary Background Identifying metabolomic profiles of children with asthma has the potential to increase understanding of asthma pathophysiology. Objective To…”
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Metabolomic analysis of 92 pulmonary embolism patients from a nested case–control study identifies metabolites associated with adverse clinical outcomes by Zeleznik, O. A., Poole, E. M., Lindstrom, S., Kraft, P., Van Hylckama Vlieg, A., Lasky‐Su, J. A., Harrington, L. B., Hagan, K., Kim, J., Parry, B. A., Giordano, N., Kabrhel, C.

“…Essentials Risk‐stratification often fails to predict clinical deterioration in pulmonary embolism (PE). First‐ever high‐throughput metabolomics analysis of…”
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TSLP polymorphisms are associated with asthma in a sex‐specific fashion by Hunninghake, G.M, Soto‐Quirós, M.E, Avila, L, Kim, H.P, Lasky‐Su, J, Rafaels, N, Ruczinski, I, Beaty, T.H, Mathias, R.A, Barnes, K.C, Wilk, J.B, O'Connor, G.T, James Gauderman, W, Vora, H, Baurley, J.W, Gilliland, F, Liang, C, Sylvia, J.S, Klanderman, B.J, Sharma, S.S, Himes, B.E, Bossley, C.J, Israel, E, Raby, B.A, Bush, A, Choi, A.M, Weiss, S.T, Celedón, J.C

“…To cite this article: Hunninghake GM, Soto‐Quirós ME, Avila L, Kim HP, Lasky‐Su J, Rafaels N, Ruczinski I, Beaty TH, Mathias RA, Barnes KC, Wilk JB, O'Connor…”
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Gene editing in the context of an increasingly complex genome by Blighe, K, DeDionisio, L, Christie, K A, Chawes, B, Shareef, S, Kakouli-Duarte, T, Chao-Shern, C, Harding, V, Kelly, R S, Castellano, L, Stebbing, J, Lasky-Su, J A, Nesbit, M A, Moore, C B T

“…The reporting of the first draft of the human genome in 2000 brought with it much hope for the future in what was felt as a paradigm shift toward improved…”
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HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults by Lasky-Su, J., Himes, B. E., Raby, B. A., Klanderman, B. J., Sylvia, J. Senter, Lange, C., Melen, E., Martinez, F. D., Israel, E., Gauderman, J., Gilliland, F., Sleiman, P., Hakonarson, H., Celedón, J. C., Soto-Quiros, M., Avila, L., Lima, J. J., Irvin, C. G., Peters, S. P., Boushey, H., Chinchilli, V. M., Mauger, D., Tantisira, K., Weiss, S. T.

“…Summary Background Asthma is a common chronic respiratory disease in children and adults. An important genetic component to asthma susceptibility has long been…”
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Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan by Glatt, S J, Faraone, S V, Lasky-Su, J A, Kanazawa, T, Hwu, H-G, Tsuang, M T

“…The gene that codes for dopamine receptor D2 ( DRD2 on chromosome 11q23) has long been a prime functional and positional candidate risk gene for schizophrenia…”
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Evidence for an Association of the Dopamine D5 Receptor Gene on Age at Onset of Attention Deficit Hyperactivity Disorder by Lasky‐Su, J., Biederman, J., Laird, N., Tsuang, M., Doyle, A. E., Smoller, J. W., Lange, C., Faraone, S. V.

“…Summary The purpose of this study was to determine whether the single nucleotide polymorphisms (SNPs) within candidate genes for attention deficit…”
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Genome-wide association study of body mass index in 23 000 individuals with and without asthma by Melén, E., Granell, R., Kogevinas, M., Strachan, D., Gonzalez, J. R., Wjst, M., Jarvis, D., Ege, M., Braun-Fahrländer, C., Genuneit, J., Horak, E., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., Michel, S., von Berg, A., Heinzmann, A., Kabesch, M., Probst-Hensch, N. M., Curjuric, I., Imboden, M., Rochat, T., Henderson, J., Sterne, J. A. C., McArdle, W. L., Hui, J., James, A. L., William Musk, A., Palmer, L. J., Becker, A., Kozyrskyj, A. L., Chan-Young, M., Park, J. E., Leung, A., Daley, D., Freidin, M. B., Deev, I. A., Ogorodova, L. M., Puzyrev, V. P., Celedón, J. C., Brehm, J. M., Cloutier, M. M., Canino, G., Acosta-Pérez, E., Soto-Quiros, M., Avila, L., Bergström, A., Magnusson, J., Söderhäll, C., Kull, I., Scholtens, S., Marike Boezen, H., Koppelman, G. H., Wijga, A. H., Marenholz, I., Esparza-Gordillo, J., Lau, S., Lee, Y.-A., Standl, M., Tiesler, C. M. T., Flexeder, C., Heinrich, J., Myers, R. A., Ober, C., Nicolae, D. L., Farrall, M., Kumar, A., Moffatt, M. F., Cookson, W. O. C. M., Lasky-Su, J.

“…Summary Background Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between…”
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A genome-wide association study of bronchodilator response in asthmatics by Duan, Q L, Lasky-Su, J, Himes, B E, Qiu, W, Litonjua, A A, Damask, A, Lazarus, R, Klanderman, B, Irvin, C G, Peters, S P, Hanrahan, J P, Lima, J J, Martinez, F D, Mauger, D, Chinchilli, V M, Soto-Quiros, M, Avila, L, Celedón, J C, Lange, C, Weiss, S T, Tantisira, K G

“…Reversibility of airway obstruction in response to β 2 -agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a…”
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A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics by Duan, Q L, Du, R, Lasky-Su, J, Klanderman, B J, Partch, A B, Peters, S P, Irvin, C G, Hanrahan, J P, Lima, J J, Blake, K V, Liggett, S B, Litonjua, A A, Tantisira, K G

“…A pro-asthmatic culture milieu and β 2 -agonist (isoproterenol) were previously shown to regulate the expression of select transcription factors (TFs) within…”
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Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder by Christiansen, H., Chen, W., Oades, R. D., Asherson, P., Taylor, E. A., Lasky-Su, J., Zhou, K., Banaschewski, T., Buschgens, C., Franke, B., Gabriels, I., Manor, I., Marco, R., Müller, U. C., Mulligan, A., Psychogiou, L., Rommelse, N. N. J., Uebel, H., Buitelaar, J., Ebstein, R. P., Eisenberg, J., Gill, M., Miranda, A., Mulas, F., Roeyers, H., Rothenberger, A., Sergeant, J. A., Sonuga-Barke, E. J. S., Steinhausen, H.-C., Thompson, M., Faraone, S. V.

“…Summary Common disorders of childhood and adolescence are attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct…”
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Statistical challenges for genome-wide association studies of suicidality using family data by Lasky-Su, J, Lange, C

“…Abstract The etiology of suicide is complex in nature with both environmental and genetic causes that are extremely diverse. This extensive heterogeneity…”
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S.18.05 Molecular-genetics of aggression and antisocial behaviour in clinical populations by Anney, R, Lasky-Su, J, The Image Consortium

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A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families by Lasky-Su, J, Faraone, Stephen V, Lange, C, Tsuang, M T, Doyle, A E, Smoller, J W, Laird, N M, Biederman, J

“…Recent animal research suggests that brain-derived neurotrophic factor (BDNF), may mediate response to different environmental stimuli. In this paper, we…”
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Validation of biomarkers of aging by Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Ying, Kejun, Justice, Jamie N., Belsky, Daniel W., Higgins-Chen, Albert T., Chen, Brian H., Cohen, Alan A., Fuellen, Georg, Hägg, Sara, Marioni, Riccardo E., Widschwendter, Martin, Fortney, Kristen, Fedichev, Peter O., Zhavoronkov, Alex, Barzilai, Nir, Lasky-Su, Jessica, Kiel, Douglas P., Kennedy, Brian K., Cummings, Steven, Slagboom, P. Eline, Verdin, Eric, Maier, Andrea B., Sebastiano, Vittorio, Snyder, Michael P., Gladyshev, Vadim N., Horvath, Steve, Ferrucci, Luigi

“…The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers could predict…”
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Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype by Rago, Daniela, Pedersen, Casper-Emil T, Huang, Mengna, Kelly, Rachel S, Gürdeniz, Gözde, Brustad, Nicklas, Knihtilä, Hanna, Lee-Sarwar, Kathleen A, Morin, Andréanne, Rasmussen, Morten A, Stokholm, Jakob, Bønnelykke, Klaus, Litonjua, Augusto A, Wheelock, Craig E, Weiss, Scott T, Lasky-Su, Jessica, Bisgaard, Hans, Chawes, Bo L

“…A link among sphingolipids, 17q21 genetic variants, and childhood asthma has been suggested, but the underlying mechanisms and characteristics of such an…”
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Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism by Prince, Nicole, Begum, Sofina, Mínguez-Alarcón, Lidia, Génard-Walton, Maximilien, Huang, Mengna, Soeteman, Djøra I., Wheelock, Craig, Litonjua, Augusto A., Weiss, Scott T., Kelly, Rachel S., Lasky-Su, Jessica

“…Exposure to per- and polyfluoroalkyl substances (PFAS) through the environment can lead to harmful health outcomes and the development of disease. However,…”
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Maternal vitamin D–related metabolome and offspring risk of asthma outcomes by Kim, Min, Brustad, Nicklas, Ali, Mina, Gürdeniz, Gözde, Arendt, Morten, Litonjua, Augusto A., Wheelock, Craig E., Kelly, Rachel S., Chen, Yulu, Prince, Nicole, Guo, Feng, Zhou, Xiaobo, Stokholm, Jakob, Bønnelykke, Klaus, Weiss, Scott T., Bisgaard, Hans, Lasky-Su, Jessica, Chawes, Bo

“…[Display omitted] Gestational vitamin D deficiency is implicated in development of respiratory diseases in offspring, but the mechanism underlying this…”
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Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts by Kelly, Rachel S, Mendez, Kevin M, Huang, Mengna, Hobbs, Brian D, Clish, Clary B, Gerszten, Robert, Cho, Michael H, Wheelock, Craig E, McGeachie, Michael J, Chu, Su H, Celedón, Juan C, Weiss, Scott T, Lasky-Su, Jessica

“…Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a more detailed molecular classification is needed. Metabolomics represents…”
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Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study by Djukanović, Ratko, Brinkman, Paul, Kolmert, Johan, Gomez, Cristina, Schofield, James, Brandsma, Joost, Shapanis, Andy, Skipp, Paul J S, Postle, Anthony, Wheelock, Craig, Dahlen, Sven-Erik, Sterk, Peter J, Brown, Thomas, Jackson, David J, Mansur, Adel, Pavord, Ian, Patel, Mitesh, Brightling, Christopher, Siddiqui, Salman, Bradding, Peter, Sabroe, Ian, Saralaya, Dinesh, Chishimba, Livingstone, Porter, Joanna, Robinson, Douglas, Fowler, Stephen, Howarth, Peter H, Little, Louisa, Oliver, Thomas, Hill, Kayleigh, Stanton, Louise, Allen, Alexander, Ellis, Deborah, Griffiths, Gareth, Harrison, Tim, Akenroye, Ayobami, Lasky-Su, Jessica, Heaney, Liam, Chaudhuri, Rekha, Kurukulaaratchy, Ramesh

“…The anti-IgE monoclonal antibody omalizumab is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during…”
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