Search Results - "Lasky, Joseph"

Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway by Saito, Shigeki, Zhuang, Yan, Shan, Bin, Danchuk, Svitlana, Luo, Fayong, Korfei, Martina, Guenther, Andreas, Lasky, Joseph A

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via…”
Get full text

Novel mediators of idiopathic pulmonary fibrosis by Saito, Shigeki, Deskin, Brian, Rehan, Mohammad, Yadav, Santosh, Matsunaga, Yasuka, Lasky, Joseph A, Thannickal, Victor J

“…Fibrosis involving the lung may occur in many settings, including in association with known environmental agents, connective tissue diseases, and exposure to…”
Get more information

In search of druggable targets for GBM amino acid metabolism by Panosyan, Eduard H, Lin, Henry J, Koster, Jan, Lasky, 3rd, Joseph L

“…Amino acid (AA) pathways may contain druggable targets for glioblastoma (GBM). Literature reviews and GBM database ( http://r2.amc.nl ) analyses were carried…”
Get full text

Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis by Sosulski, Meredith L, Gongora, Rafael, Feghali-Bostwick, Carol, Lasky, Joseph A, Sanchez, Cecilia G

“…Oxidative stress leads to alveolar epithelial cell injury and fibroblast-myofibroblast differentiation (FMD), key events in the pathobiology of pulmonary…”
Get full text

NOTCH-ing up Surface Tension in the Fibrotic Lung by Lasky, Joseph A, Thannickal, Victor J

“…Lasky and Thannickal discuss the study by Wasnick and colleagues on surface tension in idiopathic pulmonary fibrosis (IPF). IPF occurs in a pattern that is…”
Get full text

A Phase 3 Trial of l-Glutamine in Sickle Cell Disease by Niihara, Yutaka, Miller, Scott T, Kanter, Julie, Lanzkron, Sophie, Smith, Wally R, Hsu, Lewis L, Gordeuk, Victor R, Viswanathan, Kusum, Sarnaik, Sharada, Osunkwo, Ifeyinwa, Guillaume, Edouard, Sadanandan, Swayam, Sieger, Lance, Lasky, Joseph L, Panosyan, Eduard H, Blake, Osbourne A, New, Tamara N, Bellevue, Rita, Tran, Lan T, Razon, Rafael L, Stark, Charles W, Neumayr, Lynne D, Vichinsky, Elliott P

“…A year-long, phase 3, randomized trial involving patients with sickle cell disease showed that the median number of pain crises was 25% lower and the median…”
Get full text

Prednisone, Azathioprine, and N-Acetylcysteine for Pulmonary Fibrosis by Raghu, Ganesh, Anstrom, Kevin J, King, Jr, Talmadge E, Lasky, Joseph A, Martinez, Fernando J

“…Many treatments used for idiopathic pulmonary fibrosis (IPF) have not been rigorously tested. This article reports discontinuation of treatment with…”
Get full text

Pharmacotherapy and adjunctive treatment for idiopathic pulmonary fibrosis (IPF) by Saito, Shigeki, Alkhatib, Ala, Kolls, Jay K, Kondoh, Yasuhiro, Lasky, Joseph A

“…Idiopathic pulmonary fibrosis (IPF) is an advancing and fatal lung disease with increasing incidence and prevalence. Nintedanib and pirfenidone were approved…”
Get full text

Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis by Korfei, Martina, Stelmaszek, Daniel, MacKenzie, BreAnne, Skwarna, Sylwia, Chillappagari, Shashipavan, Bach, Anna C, Ruppert, Clemens, Saito, Shigeki, Mahavadi, Poornima, Klepetko, Walter, Fink, Ludger, Seeger, Werner, Lasky, Joseph A, Pullamsetti, Soni S, Krämer, Oliver H, Guenther, Andreas

“…Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a poor prognosis. Pirfenidone is the first antifibrotic agent to be approved for…”
Get full text

Update in Interstitial Lung Disease 2020 by Podolanczuk, Anna J, Wong, Alyson W, Saito, Shigeki, Lasky, Joseph A, Ryerson, Christopher J, Eickelberg, Oliver

“…Podolanczuk et al provide an update in interstitial lung disease for 2020. The emergence of severe acute respiratory syndrome coronavirus 2…”
Get full text

Associations of circulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases with clinically relevant outcomes in idiopathic pulmonary fibrosis: Data from the IPF-PRO Registry by Amubieya, Olawale, Todd, Jamie L, Neely, Megan L, Kaner, Robert J, Lasky, Joseph A, Namen, Andrew, Hesslinger, Christian, Palmer, Scott M, Weigt, S Samuel, Belperio, John A

“…We assessed the prognostic utility of circulating levels of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in…”
Get full text

Safety, tolerability and appropriate use of nintedanib in idiopathic pulmonary fibrosis by Corte, Tamera, Bonella, Francesco, Crestani, Bruno, Demedts, Maurits G, Richeldi, Luca, Coeck, Carl, Pelling, Katy, Quaresma, Manuel, Lasky, Joseph A

“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterised by dyspnea and loss of lung function. Using pooled data from the replicate,…”
Get full text

A New Piece to Help Solve the Interstitial Lung Disease Diagnostic Puzzle by Cosgrove, Gregory P, Lasky, Joseph A

“…Cosgrove and Lasky discuss the study of Richeldi et al which explored the use of a genomic classifier (GC) of lung tissue derived from pooled transbronchial…”
Get full text

HDAC8 inhibition ameliorates pulmonary fibrosis by Saito, Shigeki, Zhuang, Yan, Suzuki, Takayoshi, Ota, Yosuke, Bateman, Marjorie E, Alkhatib, Ala L, Morris, Gilbert F, Lasky, Joseph A

“…Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative lung disease, and fibroblast-myofibroblast differentiation (FMD) is thought to be a key event in…”
Get more information

Using Bronchoscopic Lung Cryobiopsy and a Genomic Classifier in the Multidisciplinary Diagnosis of Diffuse Interstitial Lung Diseases by Kheir, Fayez, Alkhatib, Ala, Berry, Gerald J., Daroca, Philip, Diethelm, Lisa, Rampolla, Reinaldo, Saito, Shigeki, Smith, David L., Weill, David, Bateman, Marjorie, Abdelghani, Ramsy, Lasky, Joseph A.

“…Challenges remain for establishing a specific diagnosis in cases of interstitial lung disease (ILD). Bronchoscopic lung cryobiopsy (BLC) has impacted the…”
Get full text

Case Report: Blinatumomab as upfront consolidation and maintenance therapy in a pediatric patient with high-risk B-cell acute lymphoblastic leukemia by Gupta, Sumit, Casey, Jessica, Lasky, Joseph

“…Introduction B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. The current conventional chemotherapy regimens have high…”
Get full text

A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis by Rosas, Ivan O., Goldberg, Hilary J., Collard, Harold R., El-Chemaly, Souheil, Flaherty, Kevin, Hunninghake, Gary M., Lasky, Joseph A., Lederer, David J., Machado, Roberto, Martinez, Fernando J., Maurer, Rie, Teller, Danielle, Noth, Imre, Peters, Elizabeth, Raghu, Ganesh, Garcia, Joe G.N., Choi, Augustine M.K.

“…Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO,…”
Get full text

Imatinib Treatment for Idiopathic Pulmonary Fibrosis: Randomized Placebo-controlled Trial Results by DANIELS, Craig E, LASKY, Joseph A, LIMPER, Andrew H, MIERAS, Kathleen, GABOR, Edith, SCHROEDER, Darrell R

“…Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with no known efficacious therapy. Imatinib is a tyrosine kinase inhibitor with potential…”
Get full text

Idiopathic Pulmonary Fibrosis in United States Automated Claims. Incidence, Prevalence, and Algorithm Validation by Esposito, Daina B, Lanes, Stephan, Donneyong, Macarius, Holick, Crystal N, Lasky, Joseph A, Lederer, David, Nathan, Steven D, O'Quinn, Sean, Parker, Joseph, Tran, Trung N

“…Estimates of idiopathic pulmonary fibrosis (IPF) incidence and prevalence from electronic databases without case validation may be inaccurate. Develop claims…”
Get full text

Safety of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis: Global Pharmacovigilance Data by Lasky, Joseph A., Criner, Gerard J., Lazarus, Howard M., Kohlbrenner, Veronika, Bender, Shaun, Richeldi, Luca

“…Introduction The safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis (IPF) have been characterized using data from clinical…”
Get full text