Search Results - "Laskin, Jeffrey"

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants by Laskin, Debra L, Malaviya, Rama, Laskin, Jeffrey D

“…Abstract A diverse group of toxicants has been identified that cause injury to the lung including gases (eg, ozone, chlorine), particulates/aerosols (eg,…”
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Anti-TNFα therapy in inflammatory lung diseases by Malaviya, Rama, Laskin, Jeffrey D, Laskin, Debra L

“…Increased levels of tumor necrosis factor (TNF) α have been linked to a number of pulmonary inflammatory diseases including asthma, chronic obstructive…”
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Macrophages and Tissue Injury: Agents of Defense or Destruction? by LASKIN, Debra L, SUNIL, Vasanthi R, GARDNER, Carol R, LASKIN, Jeffrey D

“…The past several years have seen the accumulation of evidence demonstrating that tissue injury induced by diverse toxicants is due not only to their direct…”
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Hydroxyl Radicals in E‑Cigarette Vapor and E‑Vapor Oxidative Potentials under Different Vaping Patterns by Son, Yeongkwon, Mishin, Vladimir, Laskin, Jeffrey D, Mainelis, Gediminas, Wackowski, Olivia A, Delnevo, Cristine, Schwander, Stephan, Khlystov, Andrey, Samburova, Vera, Meng, Qingyu

“…Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation…”
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Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms by Malaviya, Rama, Kipen, Howard M., Businaro, Rita, Laskin, Jeffrey D., Laskin, Debra L.

“…Pulmonary fibrosis is characterized by destruction and remodeling of the lung due to an accumulation of collagen and other extracellular matrix components in…”
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Long-term Respiratory Effects of Mustard Vesicants by Malaviya, Rama, Laskin, Jeffrey D., Laskin, Debra L.

“…•Mustard gas inhalation induces acute lung injury that progresses to chronic disease.•No specific treatments are available for victims of mustard gas…”
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Disease‐modifying treatment of chemical threat agent–induced acute lung injury by Radbel, Jared, Laskin, Debra L., Laskin, Jeffrey D., Kipen, Howard M.

“…Acute respiratory distress syndrome (ARDS) is a highly morbid lung pathology induced by exposure to chemical warfare agents, including vesicants, phosgene,…”
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Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis by Venosa, Alessandro, Malaviya, Rama, Choi, Hyejeong, Gow, Andrew J, Laskin, Jeffrey D, Laskin, Debra L

“…Nitrogen mustard (NM) is an alkylating agent known to cause extensive pulmonary injury progressing to fibrosis. This is accompanied by a persistent macrophage…”
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Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids by Venosa, Alessandro, Smith, Ley Cody, Murray, Alexa, Banota, Tanvi, Gow, Andrew J, Laskin, Jeffrey D, Laskin, Debra L

“…Abstract Nitrogen mustard (NM) is a vesicant known to target the lung, causing acute injury which progresses to fibrosis. Evidence suggests that activated…”
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Menthol flavoring in e-cigarette condensate causes pulmonary dysfunction and cytotoxicity in precision cut lung slices by Herbert, Julia, Kelty, Jacklyn S, Laskin, Jeffrey D, Laskin, Debra L, Gow, Andrew J

“…E-cigarette consumption is under scrutiny by regulatory authorities due to concerns about product toxicity, lack of manufacturing standards, and increasing…”
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Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices by Bellomo, Alyssa, Herbert, Julia, Kudlak, Melissa J., Laskin, Jeffrey D., Gow, Andrew J., Laskin, Debra L.

“…Nitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex…”
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DNA damage signaling in the cellular responses to mustard vesicants by Jan, Yi-Hua, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…•Mustard vesicants such as sulfur mustard and nitrogen mustard are highly reactive with DNA.•Mustards can form monofunctional and bifunctional adducts.•Cells…”
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Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants by Andres, Jaclynn, Smith, Ley Cody, Murray, Alexa, Jin, Yang, Businaro, Rita, Laskin, Jeffrey D., Laskin, Debra L.

“…•Extracellar vesicles are released following exposure to pulmonary toxicants.•Extracellular vesicles include exosomes, microvesicles and apoptotic…”
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Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radiation by Malaviya, Rama, Laskin, Jeffrey D, Businaro, Rita, Laskin, Debra L

“…Pulmonary injury induced by mustard vesicants and radiation is characterized by DNA damage, oxidative stress, and inflammation. This is associated with…”
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Chemical warfare agent research in precision‐cut tissue slices—a useful alternative approach by Herbert, Julia, Laskin, Debra L., Gow, Andrew J., Laskin, Jeffrey D.

“…The use of chemical warfare agents (CWAs) in military conflicts and against civilians is a recurrent problem. Despite ongoing CWA research using in vitro or in…”
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Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase by Mishin, Vladimir, Heck, Diane E., Jan, Yi-Hua, Richardson, Jason R., Laskin, Jeffrey D.

“…A characteristic of cytochrome P450 (CYP) enzymes is their ability to generate H2O2, either directly or indirectly via superoxide anion, a reaction referred to…”
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Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone by Szilagyi, John T, Gorczyca, Ludwik, Brinker, Anita, Buckley, Brian, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract In the placenta, the breast cancer resistance protein (BCRP)/ABCG2 efflux transporter limits the maternal-to-fetal transfer of drugs and chemicals…”
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Re‐Purposing Drugs as Countermeasures for Chemical Weapon Toxicities: Interactive Pharmacology Training by Aleksunes, Lauren M., Gray, Joshua P., Andres, Jaclynn, Laskin, Jeffrey D., Laskin, Debra

“…The risk of a terrorist attack in the U.S. has created challenges on how to effectively treat toxicities that result from exposure to chemical weapons. To…”
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Localization of the placental BCRP/ ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity by Szilagyi, John T, Vetrano, Anna M, Laskin, Jeffrey D, Aleksunes, Lauren M

“…Abstract Introduction The breast cancer resistance protein (BCRP/ ABCG2 ) is an efflux transporter in the placental barrier. By transporting chemicals from the…”
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Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression by Venosa, Alessandro, Smith, L. Cody, Gow, Andrew J., Zarbl, Helmut, Laskin, Jeffrey D., Laskin, Debra L.

“…Activated macrophages have been implicated in lung injury and fibrosis induced by the cytotoxic alkylating agent, nitrogen mustard (NM). Herein, we determined…”
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