Search Results - "Laskin, D.L."

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing by Heck, D.E., Laskin, D.L., Gardner, C.R., Laskin, J.D.

“…In the skin, wounding initiates a complex array of physiological processes mediated by growth factors and inflammatory mediators which stimulate tissue repair…”
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Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells by Hwang, S M, Lopez, C A, Heck, D E, Gardner, C R, Laskin, D L, Laskin, J D, Denhardt, D T

“…We report that osteopontin (OPN), a secreted, Arg-Gly-Asp-containing phosphoprotein expressed at high levels in the kidney, suppresses nitric oxide (NO)…”
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Update to RIFM fragrance ingredient safety assessment, isobutyl formate, CAS Registry Number 542-55-2 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

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RIFM fragrance ingredient safety assessment, 2,6-xylenol, CAS Registry Number 576-26-1 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

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The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis by Schumacher, J.D., Kong, B., Pan, Y., Zhan, L., Sun, R., Aa, J., Rizzolo, D., Richardson, J.R., Chen, A., Goedken, M., Aleksunes, L.M., Laskin, D.L., Guo, G.L.

“…Non-alcoholic steatohepatitis (NASH) is a form of non-alcoholic fatty liver disease (NAFLD) characterized by steatosis, inflammation, and fibrosis often…”
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RIFM fragrance ingredient safety assessment, 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone, CAS Registry number 61315-75-1 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

“…The existing information supports the use of this material as described in this safety assessment. 4-(4-Methyl-3-penten-1-yl)-2(5H)-furanone was evaluated for…”
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RIFM fragrance ingredient safety assessment, 4-(4,8-dimethylnona-3,7-dienyl)pyridine, CAS Registry Number 38462-23-6 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

“…•4-(4,8-Dimethylnona-3,7-dienyl)pyridine; a safety assessment based on RIFM’s criteria.•A safety assessment based on 7 human health endpoints plus…”
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RIFM fragrance ingredient safety assessment, 1,3-propanediol, 2,2-dimethyl-, 1,3-diacetate, CAS Registry Number 13431-57-7 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

“…•1,3-Propanediol, 2,2-dimethyl-, 1,3-diacetate; a safety assessment based on RIFM’s criteria.•A safety assessment based on 7 human health endpoints plus…”
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Update to RIFM fragrance ingredient safety assessment, 3-(cis-3-hexenyloxy)propanenitrile, CAS Registry Number 142653-61-0 by Api, A.M., Bartlett, A., Belsito, D., Botelho, D., Bruze, M., Bryant-Friedrich, A., Burton, G.A., Cancellieri, M.A., Chon, H., Cronin, M., Crotty, S., Dagli, M.L., Dekant, W., Deodhar, C., Farrell, K., Fryer, A.D., Jones, L., Joshi, K., Lapczynski, A., Laskin, D.L., Lavelle, M., Lee, I., Moustakas, H., Muldoon, J., Penning, T.M., Piersma, A.H., Ritacco, G., Sadekar, N., Schember, I., Schultz, T.W., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y.

“…•3-(cis-3-Hexenyloxy)propanenitrile; a safety assessment based on RIFM’s criteria.•A safety assessment based on 7 human health endpoints plus…”
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possible mechanism of psoralen phototoxicity not involving direct interaction with DNA by Laskin, J.D, Lee, E, Yurkow, E.J, Laskin, D.L, Gallo, M.A

“…Psoralens in combination with ultraviolet light (UVA; 320-400 nm) are used in the photochemical treatment of a variety of skin diseases including vitiligo, a…”
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Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: Implications for microemboli-based drug delivery systems by Kutscher, H.L., Gao, D., Li, S., Massa, C.B., Cervelli, J., Deshmukh, M., Joseph, L.B., Laskin, D.L., Sinko, P.J.

“…The toxicodynamic relationship between the number and size of pulmonary microemboli resulting from uniformly sized, rigid polystyrene microparticles (MPs)…”
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The role of tumor necrosis factor-α and nitric oxide in acute liver injury induced by carbon tetrachloride by Morio, L.A., Laskin, D.L.

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Role of inflammatory cytokines in hepatic and pulmonary toxicity by Laskin, D.L., Heck, D.E., Laskin, J.D.

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Mice lacking inducible nitric oxide synthase are protected from acetaminophen-induced hepato-toxicity by Laskin, J.D., Gardner, C.R., Heck, D.E., Chiu, H., Durham, S.K., Laskin, D.L.

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Role of Nitric Oxide in Hematosuppression and Benzene-Induced Toxicity by Laskin, Debra L., Heck, Diane E., Punjabi, Chitra J., Laskin, Jeffrey D.

“…It is becoming increasingly apparent that nitric oxide plays a multifunctional role in regulating inflammatory processes in the body. Although nitric oxide and…”
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Pulmonary and Hepatic Effects of Inhaled Ozone in Rats by Laskin, Debra L., Pendino, Kimberly J., Punjabi, Chitra J., del Valle, Marina Rodriguez, Laskin, Jeffrey D.

“…Nitric oxide is a highly reactive molecule that has been implicated in host defense and in tissue injury. In the present studies we analyzed the effects of…”
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Activation of Bone Marrow Phagocytes Following Benzene Treatment of Mice by Laskin, Debra L., MacEachern, Laureen, Snyder, Robert

“…Techniques in flow cytometry/cell sorting were used to characterize the effects of benzene and its metabolites on subpopulations of bone marrow cells…”
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Induction of functionally active platelet-activating factor receptors in rat alveolar macrophages by PENDINO, K. J, GARDNER, C. R, LASKIN, J. D, LASKIN, D. L

“…Freshly isolated alveolar macrophages from control rats express low numbers of platelet-activating factor (PAF) receptors (4.6 x 10(3) binding sites/cell, Kd =…”
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Psoralens Potentiate Ultraviolet Light-Induced Inhibition of Epidermal Growth Factor Binding by Laskin, Jeffrey D., Lee, Edmund, Laskin, Debra L., Gallo, Michael A.

“…The psoralens, when activated by ultraviolet light of 320-400 nm (UVA light), are potent modulators of epidermal cell growth and differentiation. Previously,…”
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