Search Results - "Laskey, Sarah B."

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure by Ho, Ya-Chi, Shan, Liang, Hosmane, Nina N., Wang, Jeffrey, Laskey, Sarah B., Rosenbloom, Daniel I.S., Lai, Jun, Blankson, Joel N., Siliciano, Janet D., Siliciano, Robert F.

“…Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting CD4+ T cells. T cell activation reverses latency, but <1% of…”
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A mechanistic theory to explain the efficacy of antiretroviral therapy by Laskey, Sarah B., Siliciano, Robert F.

“…Combination antiretroviral therapy (cART) has revolutionized the treatment of HIV-1 infection, but the mechanistic basis of successful treatment is poorly…”
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Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality by Laskey, Sarah B, Pohlmeyer, Christopher W, Bruner, Katherine M, Siliciano, Robert F

“…In HIV-infected individuals receiving suppressive antiretroviral therapy, the virus persists indefinitely in a reservoir of latently infected cells. The…”
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Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses by Pohlmeyer, Christopher W, Laskey, Sarah B, Beck, Sarah E, Xu, Daniel C, Capoferri, Adam A, Garliss, Caroline C, May, Megan E, Livingston, Alison, Lichmira, Walt, Moore, Richard D, Leffell, M Sue, Butler, Nicholas J, Thorne, Jennifer E, Flynn, John A, Siliciano, Robert F, Blankson, Joel N

“…Heterologous immunity is an important aspect of the adaptive immune response. We hypothesized that this process could modulate the HIV-1-specific CD8+ T cell…”
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Re-evaluating evolution in the HIV reservoir by Rosenbloom, Daniel I. S., Hill, Alison L., Laskey, Sarah B., Siliciano, Robert F.

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Identifying Ashkenazi Jewish BRCA1/2 founder variants in individuals who do not self-report Jewish ancestry by Tennen, Ruth I., Laskey, Sarah B., Koelsch, Bertram L., McIntyre, Matthew H., Tung, Joyce Y.

“…Current guidelines recommend BRCA1 and BRCA2 genetic testing for individuals with a personal or family history of certain cancers. Three BRCA1/2 founder…”
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Defective proviruses rapidly accumulate during acute HIV-1 infection by Bruner, Katherine M, Murray, Alexandra J, Pollack, Ross A, Soliman, Mary G, Laskey, Sarah B, Capoferri, Adam A, Lai, Jun, Strain, Matthew C, Lada, Steven M, Hoh, Rebecca, Ho, Ya-Chi, Richman, Douglas D, Deeks, Steven G, Siliciano, Janet D, Siliciano, Robert F

“…Bruner et al . report that defective HIV-1 proviruses predominate in early infection, even when antiretroviral therapy is initiated in the first months after…”
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Quantitative evaluation of the antiretroviral efficacy of dolutegravir by Laskey, Sarah B, Siliciano, Robert F

“…The second-generation HIV-1 integrase strand transfer inhibitor (InSTI) dolutegravir (DTG) has had a major impact on the treatment of HIV-1 infection. Here we…”
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Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance by Gray, William T, Frey, Kathleen M, Laskey, Sarah B, Mislak, Andrea C, Spasov, Krasimir A, Lee, Won-Gil, Bollini, Mariela, Siliciano, Robert F, Jorgensen, William L, Anderson, Karen S

“…Catechol diether compounds have nanomolar antiviral and enzymatic activity against HIV with reverse transcriptase (RT) variants containing K101P, a mutation…”
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Cross-reactive microbial peptides can modulate HIV-specific CD8.sup.+ T cell responses by Pohlmeyer, Christopher W, Laskey, Sarah B, Beck, Sarah E, Xu, Daniel C, Capoferri, Adam A, Garliss, Caroline C, May, Megan E, Livingston, Alison, Lichmira, Walt, Moore, Richard D, Leffell, M. Sue, Butler, Nicholas J, Thorne, Jennifer E, Flynn, John A, Siliciano, Robert F, Blankson, Joel N

“…Heterologous immunity is an important aspect of the adaptive immune response. We hypothesized that this process could modulate the HIV-1-specific CD8.sup.+ T…”
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Re-evaluating evolution in the HIV reservoir/Lorenzo-Redondo et al. reply by Rosenbloom, Daniel I S, Hill, Alison L, Laskey, Sarah B, Siliciano, Robert F, Lorenzo-Redondo, Ramon, Fryer, Helen R, Bedford, Trevor, Kim, Eun-Young, Archer, John, Pond, Sergei L Kosakovsky, Chung, Yoon-Seok, Penugonda, Sudhir, Chipman, Jeffrey G, Fletcher, Courtney V, Schacker, Timothy W, Malim, Michael H, Rambaut, Andrew, Haase, Ashley T, McLean, Angela R, Wolinsky, Steven M

“…Despite antiretroviral therapy (ART), a latent reservoir of replication-competent HIV-1 persists in resting memory CD4+ T cells and precludes a cure1-6…”
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Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure by Ho, Ya-Chi, Shan, Liang, Hosmane, Nina N., Wang, Jeffrey, Laskey, Sarah B., Rosenbloom, Daniel I. S., Lai, Jun, Blankson, Joel N., Siliciano, Janet D., Siliciano, Robert F.

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