Search Results - "Lasheras, Juan C."

The biomechanics of arterial aneurysms by LASHERAS, Juan C

“…The formation of an arterial aneurysm is believed to be a multifactorial and predominantly degenerative process, resulting from a complex interplay between…”
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Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy by del Álamo, Juan C, Meili, Ruedi, Álvarez-González, Begoña, Alonso-Latorre, Baldomero, Bastounis, Effie, Firtel, Richard, Lasheras, Juan C

“…We introduce a novel three-dimensional (3D) traction force microscopy (TFM) method motivated by the recent discovery that cells adhering on plane surfaces…”
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FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells by Hu, Ying-Li, Lu, Shaoying, Szeto, Kai W., Sun, Jie, Wang, Yingxiao, Lasheras, Juan C., Chien, Shu

“…Cell migration requires the fine spatiotemporal integration of many proteins that regulate the fundamental processes that drive cell movement. Focal adhesion…”
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Three-Dimensional Balance of Cortical Tension and Axial Contractility Enables Fast Amoeboid Migration by Álvarez-González, Begoña, Meili, Ruedi, Bastounis, Effie, Firtel, Richard A., Lasheras, Juan C., del Álamo, Juan C.

“…Fast amoeboid migration requires cells to apply mechanical forces on their surroundings via transient adhesions. However, the role these forces play in…”
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Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis by Yeh, Yi-Ting, Serrano, Ricardo, François, Joshua, Chiu, Jeng-Jiann, Li, Yi-Shuan Julie, del Álamo, Juan C., Chien, Shu, Lasheras, Juan C.

“…Leukocyte transmigration across vessel walls is a critical step in the innate immune response. Upon their activation and firm adhesion to vascular endothelial…”
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Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells by Hur, Sung Sik, del Álamo, Juan C, Park, Joon Seok, Li, Yi-Shuan, Nguyen, Hong A, Teng, Dayu, Wang, Kuei-Chun, Flores, Leona, Alonso-Latorre, Baldomero, Lasheras, Juan C, Chien, Shu

“…We use a novel 3D inter-/intracellular force microscopy technique based on 3D traction force microscopy to measure the cell–cell junctional and intracellular…”
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Both contractile axial and lateral traction force dynamics drive amoeboid cell motility by Bastounis, Effie, Meili, Ruedi, Álvarez-González, Begoña, Francois, Joshua, del Álamo, Juan C, Firtel, Richard A, Lasheras, Juan C

“…Chemotaxing Dictyostelium discoideum cells adapt their morphology and migration speed in response to intrinsic and extrinsic cues. Using Fourier traction force…”
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Spatio-Temporal Analysis of Eukaryotic Cell Motility by Improved Force Cytometry by Álamo, Juan C. del, Meili, Ruedi, Alonso-Latorre, Baldomero, Rodríguez-Rodríguez, Javier, Aliseda, Alberto, Firtel, Richard A., Lasheras, Juan C.

“…Cell motility plays an essential role in many biological systems, but precise quantitative knowledge of the biophysical processes involved in cell migration is…”
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The mechanics of the adhesive locomotion of terrestrial gastropods by Lai, Janice H, del Alamo, Juan C, Rodríguez-Rodríguez, Javier, Lasheras, Juan C

“…Research on the adhesive locomotion of terrestrial gastropods is gaining renewed interest as it provides a source of guidance for the design of soft biomimetic…”
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Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation by Yeh, Yi-Ting, Skinner, Danielle E, Criado-Hidalgo, Ernesto, Chen, Natalie Shee, Garcia-De Herreros, Antoni, El-Sakkary, Nelly, Liu, Lawrence, Zhang, Shun, Kandasamy, Adithan, Chien, Shu, Lasheras, Juan C, Del Álamo, Juan C, Caffrey, Conor R

“…The eggs of the parasitic blood fluke, Schistosoma, are the main drivers of the chronic pathologies associated with schistosomiasis, a disease of poverty…”
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Myosin II is essential for the spatiotemporal organization of traction forces during cell motility by Meili, Ruedi, Alonso-Latorre, Baldomero, del Alamo, Juan C, Firtel, Richard A, Lasheras, Juan C

“…Amoeboid motility requires spatiotemporal coordination of biochemical pathways regulating force generation and consists of the quasi-periodic repetition of a…”
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Shp2 plays a crucial role in cell structural orientation and force polarity in response to matrix rigidity by Lee, Hsiao-Hui, Lee, Hsin-Chang, Chou, Chih-Chiang, Hur, Sung Sik, Osterday, Katie, del Álamo, Juan C., Lasheras, Juan C., Chien, Shu

“…Cells can sense and respond to physical properties of their surrounding extracellular matrix. We have demonstrated here that tyrosine phosphatase Shp2 plays an…”
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Elucidating the Biomechanics of Leukocyte Transendothelial Migration by Quantitative Imaging by Schwartz, Amy B, Campos, Obed A, Criado-Hidalgo, Ernesto, Chien, Shu, Del Álamo, Juan C, Lasheras, Juan C, Yeh, Yi-Ting

“…Leukocyte transendothelial migration is crucial for innate immunity and inflammation. Upon tissue damage or infection, leukocytes exit blood vessels by…”
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Anisotropic rheology and directional mechanotransduction in vascular endothelial cells by del Álamo, Juan C, Norwich, Gerard N, Li, Yi-shuan Julie, Lasheras, Juan C, Chien, Shu

“…Adherent cells remodel their cytoskeleton, including its directionality, in response to directional mechanical stimuli with consequent redistribution of…”
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Hemodynamic changes due to stent placement in bifurcating intracranial aneurysms by CANTON, Gador, LEVY, David I, LASHERAS, Juan C

“…The aim of this study was to measure changes in intraaneurysm flow dynamics and mechanical stresses resulting from the placement of Neuroform stents in…”
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Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease by Zhu, Terry, Chiacchia, Samuel, Kameny, Rebecca J., Garcia De Herreros, Antoni, Gong, Wenhui, Raff, Gary W., Boehme, Jason B., Maltepe, Emin, Lasheras, Juan C., Black, Stephen M., Datar, Sanjeev A., Fineman, Jeffrey R.

“…The risk and progression of pulmonary vascular disease in patients with congenital heart disease is dependent on the hemodynamics associated with different…”
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Three-Dimensional Monolayer Stress Microscopy by Serrano, Ricardo, Aung, Aereas, Yeh, Yi-Ting, Varghese, Shyni, Lasheras, Juan C., del Álamo, Juan C.

“…Many biological processes involve the collective generation and transmission of mechanical stresses across cell monolayers. In these processes, the monolayer…”
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Interaction of a Migrating Cell Monolayer with a Flexible Fiber by Valencia, Leticia, López-Llorente, Verónica, Lasheras, Juan C., Jorcano, José L., Rodríguez-Rodríguez, Javier

“…Mechanical forces influence the development and behavior of biological tissues. In many situations, these forces are exerted or resisted by elastic compliant…”
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Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms by Salsac, Anne-Virginie, Sparks, Steven R, Lasheras, Juan C

“…The purpose of this study is to characterize the evolution of the hemodynamic forces acting on the arterial walls at progressive stages of enlargement of…”
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Two-Layer Elastographic 3-D Traction Force Microscopy by Álvarez-González, Begoña, Zhang, Shun, Gómez-González, Manuel, Meili, Ruedi, Firtel, Richard A., Lasheras, Juan C., del Álamo, Juan C.

“…Cellular traction force microscopy (TFM) requires knowledge of the mechanical properties of the substratum where the cells adhere to calculate cell-generated…”
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