Persistence of penicillin G benzathine in pregnant group B streptococcus carriers

Persistence of penicillin G benzathine in pregnant group B streptococcus carriers

To determine if streptococcicidal levels of penicillin G benzathine can be detected in maternal serum 4 weeks after treatment with 4.8 million units. Thirty-seven pregnant women with positive group B streptococcus vaginal or urine cultures were each given 4.8 million units of penicillin G benzathine...

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Bibliographic Details
Published in:Obstetrics and gynecology (New York. 1953) Vol. 90; no. 2; pp. 240 - 243
Main Authors: Weeks, Jonathan W., Myers, Steven R., Lasher, Lisa, Goldsmith, Jane, Watkins, Christopher, Gall, Stanley A.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-08-1997
The American College of Obstetricians and Gynecologists
Elsevier Science
Subjects:
Adult
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Carrier State
Female
Fetal Blood - chemistry
Humans
Infant, Newborn
Medical sciences
Penicillin G Benzathine - administration & dosage
Penicillin G Benzathine - blood
Penicillin G Benzathine - therapeutic use
Penicillins - administration & dosage
Penicillins - blood
Penicillins - therapeutic use
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - microbiology
Streptococcal Infections - drug therapy
Streptococcal Infections - prevention & control
Streptococcus agalactiae - drug effects
Streptococcus agalactiae - isolation & purification
Time Factors
Human
Concentration factor
Benzylpenicillin
Infection
Pregnancy
Penicillin derivatives
Streptococcaceae
Antibiotic
Chemotherapy
Treatment
Streptococcal infection
Streptococcus B
Bacteriosis
Bacteria
Micrococcales
Female
Serum
Antibacterial agent
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Summary:To determine if streptococcicidal levels of penicillin G benzathine can be detected in maternal serum 4 weeks after treatment with 4.8 million units. Thirty-seven pregnant women with positive group B streptococcus vaginal or urine cultures were each given 4.8 million units of penicillin G benzathine. Maternal blood samples were collected after injection and at delivery. Serum penicillin levels were measured by high-pressure liquid chromatography. Follow-up cultures were done when possible. None of the patients had serum penicillin levels below 0.20 μg/mL 30 days after treatment. Cord blood levels were approximately 50% lower than maternal levels. In all but three subjects, cord blood levels exceeded 0.06 μg/mL, the minimal inhibitory concentration for group B streptococcus. The three exceptions were patients who delivered more than 100 days after treatment. Group B streptococcus cultures were negative at the time of delivery in 72% of cases. None of the patients with positive cultures were moderately or heavily colonized. In pregnant women, penicillin G benzathine levels are high enough to inhibit the growth of group B streptococcus for more than 4 weeks after injection with 4.8 million units. Further studies are needed to evaluate whether this regimen can prevent neonatal colonization and invasive group B streptococcus disease.
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ISSN:0029-7844
1873-233X
DOI:10.1016/S0029-7844(97)00247-0