Search Results - "Laschober, Gerhard"

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data by Finotello, Francesca, Mayer, Clemens, Plattner, Christina, Laschober, Gerhard, Rieder, Dietmar, Hackl, Hubert, Krogsdam, Anne, Loncova, Zuzana, Posch, Wilfried, Wilflingseder, Doris, Sopper, Sieghart, Ijsselsteijn, Marieke, Brouwer, Thomas P, Johnson, Douglas, Xu, Yaomin, Wang, Yu, Sanders, Melinda E, Estrada, Monica V, Ericsson-Gonzalez, Paula, Charoentong, Pornpimol, Balko, Justin, de Miranda, Noel Filipe da Cunha Carvalho, Trajanoski, Zlatko

“…We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data. quanTIseq was extensively validated in blood…”
Get full text

miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging by Hackl, Matthias, Brunner, Stefan, Fortschegger, Klaus, Schreiner, Carina, Micutkova, Lucia, Mück, Christoph, Laschober, Gerhard T., Lepperdinger, Günter, Sampson, Natalie, Berger, Peter, Herndler‐Brandstetter, Dietmar, Wieser, Matthias, Kühnel, Harald, Strasser, Alois, Rinnerthaler, Mark, Breitenbach, Michael, Mildner, Michael, Eckhart, Leopold, Tschachler, Erwin, Trost, Andrea, Bauer, Johann W., Papak, Christine, Trajanoski, Zlatko, Scheideler, Marcel, Grillari‐Voglauer, Regina, Grubeck‐Loebenstein, Beatrix, Jansen‐Dürr, Pidder, Grillari, Johannes

“…Summary Aging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically…”
Get full text

The impact of aging on memory T cell phenotype and function in the human bone marrow by Herndler-Brandstetter, Dietmar, Landgraf, Katja, Tzankov, Alexandar, Jenewein, Brigitte, Brunauer, Regina, Laschober, Gerhard T, Parson, Walther, Kloss, Frank, Gassner, Robert, Lepperdinger, Günter, Grubeck-Loebenstein, Beatrix

“…Age‐dependent changes of the BM drive the accumulation of a highly activated CD8+CD28− T cell population but do not impair memory T cell polyfunctionality…”
Get full text

Identification of evolutionarily conserved genetic regulators of cellular aging by Laschober, Gerhard T., Ruli, Doris, Hofer, Edith, Muck, Christoph, Carmona‐Gutierrez, Didac, Ring, Julia, Hutter, Eveline, Ruckenstuhl, Christoph, Micutkova, Lucia, Brunauer, Regina, Jamnig, Angelika, Trimmel, Daniela, Herndler‐Brandstetter, Dietmar, Brunner, Stefan, Zenzmaier, Christoph, Sampson, Natalie, Breitenbach, Michael, Fröhlich, Kai‐Uwe, Grubeck‐Loebenstein, Beatrix, Berger, Peter, Wieser, Matthias, Grillari‐Voglauer, Regina, Thallinger, Gerhard G., Grillari, Johannes, Trajanoski, Zlatko, Madeo, Frank, Lepperdinger, Günter, Jansen‐Dürr, Pidder

“…Summary To identify new genetic regulators of cellular aging and senescence, we performed genome‐wide comparative RNA profiling with selected human cellular…”
Get full text

Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan by Reitinger, Stephan, Laschober, Gerhard Thomas, Fehrer, Christine, Greiderer, Brigitte, Lepperdinger, Günter

“…Besides SPAM1 (sperm adhesion molecule 1; formerly named PH-20), further hyaluronidase-like proteins, HYAL5 (hyaluronoglucosaminidase 5) and HYALP1…”
Get full text

GiSAO.db: a database for ageing research by Hofer, Edith, Laschober, Gerhard T, Hackl, Matthias, Thallinger, Gerhard G, Lepperdinger, Günter, Grillari, Johannes, Jansen-Dürr, Pidder, Trajanoski, Zlatko

“…Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and…”
Get full text

Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data by Finotello, Francesca, Mayer, Clemens, Plattner, Christina, Laschober, Gerhard, Rieder, Dietmar, Hackl, Hubert, Krogsdam, Anne, Loncova, Zuzana, Posch, Wilfried, Wilflingseder, Doris, Sopper, Sieghart, Ijsselsteijn, Marieke, Brouwer, Thomas P, Johnson, Douglas, Xu, Yaomin, Wang, Yu, Sanders, Melinda E, Estrada, Monica V, Ericsson-Gonzalez, Paula, Charoentong, Pornpimol, Balko, Justin, da Cunha Carvalho de Miranda, Noel Filipe, Trajanoski, Zlatko

“…It was highlighted that the original article [1] contained a typesetting mistake in the name of Noel Filipe da Cunha Carvalho de Miranda. This was incorrectly…”
Get full text

Age-specific changes of mesenchymal stem cells are paralleled by upregulation of CD106 expression as a response to an inflammatory environment by Laschober, Gerhard T, Brunauer, Regina, Jamnig, Angelika, Singh, Sarvpreet, Hafen, Ulrich, Fehrer, Christine, Kloss, Frank, Gassner, Robert, Lepperdinger, Günter

“…Regeneration, tissue remodeling, and organ repair after injury, which rely on the regulated activity of tissue-borne stem cells, become increasingly…”
Get more information

Microarray analysis reveals similarity between CD8+CD28− T cells from young and elderly persons, but not of CD8+CD28+ T cells by Lazuardi, Lutfan, Herndler-Brandstetter, Dietmar, Brunner, Stefan, Laschober, Gerhard T., Lepperdinger, Günter, Grubeck-Loebenstein, Beatrix

“…We isolated highly purified CD8 + CD28 + and CD8 + CD28 − T cell populations from healthy young and elderly persons for gene expression profiling using…”
Get full text

Non-regulatory CD8+CD45RO+CD25+ T-lymphocytes may compensate for the loss of antigen-inexperienced CD8+CD45RA+ T-cells in old age by Herndler-Brandstetter, Dietmar, Veel, Ellen, Laschober, Gerhard T, Pfister, Gerald, Brunner, Stefan, Walcher, Susanne, Parson, Walther, Lepperdinger, Günter, Grubeck-Loebenstein, Beatrix

“…The age-related decline in immune system functions is responsible for the increased prevalence of infectious diseases and the low efficacy of vaccination in…”
Get more information

Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells by Laschober, Gerhard Thomas, Brunauer, Regina, Jamnig, Angelika, Fehrer, Christine, Greiderer, Brigitte, Lepperdinger, Günter

“…During the lifetime of an adult organism, stem cells face extrinsic and intrinsic aging. Mesenchymal stem cells (MSC) can be expanded in culture, and the…”
Get full text

Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan by Fehrer, Christine, Brunauer, Regina, Laschober, Gerhard, Unterluggauer, Hermann, Reitinger, Stephan, Kloss, Frank, Gülly, Christian, Gaßner, Robert, Lepperdinger, Günter

“…Summary Mesenchymal stem cells (MSC) are capable of differentiating into bone, fat, cartilage, tendon and other organ progenitor cells. Despite the abundance…”
Get full text

Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies? by Lepperdinger, Günter, Brunauer, Regina, Jamnig, Angelika, Laschober, Gerhard, Kassem, Moustapha

“…The prospective clinical use of multipotent mesenchymal stromal stem cells (MSC) holds enormous promise for the treatment of a large number of degenerative and…”
Get full text

Synthesis of (±)-trans-2,5-Diisopropylborolane by Laschober, Gerhard, Zorzi, Massimo, Hodgetts, Kevin J.

“…The cyclic hydroboration of 2,7-dimethyl-2,6-octadiene (6) was studied. It was found that the stereochemical outcome of the reaction was dependent upon the…”
Get full text

Clinical evaluation of capillary B-type natriuretic peptide testing by Schreinlechner, Michael, Mrakovic, Anita, Laschober, Gerhard, Mayerl, Christina, Griesmacher, Andrea, van Lippen, Lian, Semjonow, Veronique, Nieuwenhuis, Jeroen, van Reenen, Alexander, Mair, Johannes

“…Background Capillary B-type natriuretic peptide (BNP) testing is attractive in outpatient and emergency settings. The aim of this study was to perform an…”
Get more information

Aging of Murine Mesenchymal Stem Cells by FEHRER, CHRISTINE, LASCHOBER, GERHARD, LEPPERDINGER, GÜNTER

“…:  Mesenchymal stem cells (MSCs) are able to differentiate into distinct lineages such as adipo‐, osteo‐, and chondrocytes. MSCs were isolated from three mouse…”
Get full text

Age-associated functional changes of human mesenchymal stem cells by Brunauer, Regina, Laschober, Gerhard, Fehrer, Christine, Lepperdinger, Günter

Get full text

The role of oxygen termination of nanocrystalline diamond on immobilisation of BMP-2 and subsequent bone formation by Kloss, Frank R, Gassner, Robert, Preiner, Johannes, Ebner, Andreas, Larsson, Karin, Hächl, Oliver, Tuli, Tarkan, Rasse, Michael, Moser, Doris, Laimer, Klaus, Nickel, Eike A, Laschober, Gerhard, Brunauer, Regina, Klima, Günther, Hinterdorfer, Peter, Steinmüller-Nethl, Doris, Lepperdinger, Günter

“…Abstract Medical implants are increasingly often inserted into bone of frail patients, who are advanced in years. Due to age, severe trauma or…”
Get full text

Mini Review: Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies? by Lepperdinger, Gunter, Brunauer, Regina, Jamnig, Angelika, Laschober, Gerhard, Kassem, Moustapha

“…The prospective clinical use of multipotent mesenchymal stromal stem cells (MSC) holds enormous promise for the treatment of a large number of degenerative and…”
Get full text

High-yield recombinant expression of the extremophile enzyme, bee hyaluronidase in Pichia pastoris by Reitinger, Stephan, Boroviak, Thorsten, Laschober, Gerhard Thomas, Fehrer, Christine, Müllegger, Johannes, Lindner, Herbert, Lepperdinger, Günter

“…Hyaluronidase from honey bee was recombinantly expressed as a secreted glycoprotein in Pichia pastoris. The active enzyme was produced in milligram quantities…”
Get full text