Search Results - "Laschke, MW"

The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue by Laschke, M W, Vollmar, B, Menger, M D

“…The implantation of biomaterials into the human body has become an indispensable part of almost all fields of modern medicine. Accordingly, there is an…”
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The dorsal skinfold chamber: A versatile tool for preclinical research in tissue engineering and regenerative medicine by Laschke, M W, Menger, M D

“…The dorsal skinfold chamber is a rodent model for non-invasive microcirculatory analyses of striated muscle and skin tissue throughout an observation period of…”
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Rodent animal models of delayed bone healing and non-union formation: a comprehensive review by Garcia, P, Histing, T, Holstein, J H, Klein, M, Laschke, M W, Matthys, R, Ignatius, A, Wildemann, B, Lienau, J, Peters, A, Willie, B, Duda, G, Claes, L, Pohlemann, T, Menger, M D

“…Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain a major clinical challenge. Animal models…”
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Generation of co-culture spheroids as vascularisation units for bone tissue engineering by Walser, R, Metzger, W, Görg, A, Pohlemann, T, Menger, M D, Laschke, M W

“…Cell spheroids represent attractive building units for bone tissue engineering, because they provide a three-dimensional environment with intensive direct…”
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Erythropoietin promotes network formation of transplanted adipose tissue-derived microvascular fragments by Karschnia, P, Scheuer, C, Heß, A, Später, T, Menger, M D, Laschke, M W

“…The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF) is an emerging pre-vascularisation strategy. Ad-MVF rapidly…”
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Seeding density is a crucial determinant for the in vivo vascularisation capacity of adipose tissue-derived microvascular fragments by Später, T, Körbel, C, Frueh, F S, Nickels, R M, Menger, M D, Laschke, M W

“…Adipose tissue-derived microvascular fragments (ad-MVF) represent effective vascularisation units for the seeding of dermal substitutes. However, particularly…”
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High glucose exposure promotes proliferation and in vivo network formation of adipose-tissue-derived microvascular fragments by Laschke, M W, Seifert, M S, Scheuer, C, Kontaxi, E, Metzger, W, Menger, M D

“…High glucose concentrations have been shown to activate endothelial cells and promote angiogenesis. In the present study, it was investigated whether high…”
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Potentials and limitations of Integra® flowable wound matrix seeded with adipose tissue-derived microvascular fragments by Später, T, Frueh, F S, Menger, M D, Laschke, M W

“…Adipose tissue-derived microvascular fragments (ad-MVF) represent promising vascularisation units for bioengineered Integra® matrix wound dressing (MWD)…”
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Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments by Laschke, M W, Kleer, S, Scheuer, C, Schuler, S, Garcia, P, Eglin, D, Alini, M, Menger, M D

“…In tissue engineering, the generation of tissue constructs comprising preformed microvessels is a promising strategy to guarantee their adequate…”
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BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions by Orth, M, Kruse, N J, Braun, B J, Scheuer, C, Holstein, J H, Khalil, A, Yu, X, Murphy, W L, Pohlemann, T, Laschke, M W, Menger, M D

“…Atrophic non-unions are a major clinical problem. Mineral coated microparticles (MCM) are electrolyte-coated hydroxyapatite particles that have been shown in…”
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Adipose tissue-derived microvascular fragments from aged donors exhibit an impaired vascularisation capacity by Laschke, M W, Grässer, C, Kleer, S, Scheuer, C, Eglin, D, Alini, M, Menger, M D

“…Adipose tissue-derived microvascular fragments are promising vascularisation units for applications in the field of tissue engineering. Elderly patients are…”
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Effects of macrophage-activating lipopeptide-2 (MALP-2) on the vascularisation of implanted polyurethane scaffolds seeded with microvascular fragments by Grässer, C, Scheuer, C, Parakenings, J, Tschernig, T, Eglin, D, Menger, M D, Laschke, M W

“…The seeding of scaffolds with adipose tissue-derived microvascular fragments represents a promising strategy to establish a sufficient blood supply in tissue…”
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Pre-cultivation of adipose tissue-derived microvascular fragments in porous scaffolds does not improve their in vivo vascularisation potential by Laschke, M W, Kleer, S, Scheuer, C, Eglin, D, Alini, M, Menger, M D

“…Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into…”
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Tissue engineering and regenerative approaches to improving the healing of large bone defects by Verrier, S, Alini, M, Alsberg, E, Buchman, S R, Kelly, D, Laschke, M W, Menger, M D, Murphy, W L, Stegemann, J P, Schütz, M, Miclau, T, Stoddart, M J, Evans, C

“…Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and remain a clinical challenge. Healing such defects requires the…”
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Cell therapy for bone repair: narrowing the gap between vision and practice by Stegemann, J P, Verrier, S, Gebhard, F, Laschke, M W, Martin, I, Simpson, H, Miclau, T

“…This position paper summarises a vision of how cell-based therapies can be applied clinically to regenerate bone, as well as the steps needed to narrow the gap…”
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Perioperative steroid administration inhibits angiogenic host tissue response to porous polyethylene (Medpor) implants by Ehrmantraut, S, Laschke, M W, Merkel, D, Scheuer, C, Willnecker, V, Meyer-Lindenberg, A, Menger, M D, Naumann, A

“…Porous polyethylene (Medpor) is an alloplastic biomaterial, which is commonly used in plastic and reconstructive surgery. In the present study, we analyzed the…”
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Promoting external inosculation of prevascularised tissue constructs by pre-cultivation in an angiogenic extracellular matrix by Laschke, M W, Mussawy, H, Schuler, S, Eglin, D, Alini, M, Menger, M D

“…The engineering of preformed microvessels offers the promising opportunity to rapidly vascularise implanted tissue constructs by the process of inosculation…”
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Vasculogenesis: a new piece of the endometriosis puzzle by Laschke, M W, Giebels, C, Menger, M D

“…BACKGROUND; Endometriosis is a complex disease with a multifactorial pathogenesis, which is crucially dependent on the development of new blood vessels. Based…”
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Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions by Nenicu, Anca, Gu, Yuan, Körbel, Christina, Menger, Michael D, Laschke, Matthias W

“…Background and Purpose Telmisartan suppresses the development of endometriotic lesions. However, the drug also up‐regulates the expression of COX‐2, which has…”
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Effects of locally applied adipose tissue-derived microvascular fragments by thermoresponsive hydrogel on bone healing by Orth, M., Altmeyer, M.A.B., Scheuer, C., Braun, B.J., Holstein, J.H., Eglin, D., D'Este, M., Histing, T., Laschke, M.W., Pohlemann, T., Menger, M.D.

“…[Display omitted] Insufficient vascularization is a major cause for the development of non-unions. To overcome this problem, adipose tissue-derived…”
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