Search Results - "Lasch, S. J."

Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates by Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S., Casazza, A. M., Firestone, R. A., Hellström, I., Hellström, K. E.

“…Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an…”
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(6-Maleimidocaproyl)hydrazone of doxorubicin. A new derivative for the preparation of immunoconjugates of doxorubicin by Willner, David, Trail, Pamela A, Hofstead, Sandra J, King, H. Dalton, Lasch, Shirley J, Braslawsky, Gary R, Greenfield, Robert S, Kaneko, Takushi, Firestone, Raymond A

“…The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to…”
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Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates by TRAIL, P. A, WILLNER, D, BRASLAWSKY, G. R, BROWN, J, HOFSTEAD, S. J, GREENFIELD, R. S, FIRESTONE, R. A, MOSURE, K, KADOW, K. F, YANG, M. B, HELLSTRÖM, K. E, HELLSTRÖM, I, KNIPE, J, HENDERSON, A. J, LASCH, S. J, ZOECKLER, M. E, TRAILSMITH, M. D, DOYLE, T. W, KING, H. D, CASAZZA, A. M

“…The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the…”
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Synthesis and antitumor activity of the immunoconjugate BR96-Dox by Firestone, R.A., Willner, D., Hofstead, S.J., King, H.D., Kaneko, T., Braslawsky, G.R., Greenfield, R.S., Trail, P.A., Lasch, S.J., Henderson, A.J., Casazza, A.M., Hellström, I., Hellström, K.E.

“…BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a…”
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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Linkers:  A Novel Method for Increasing the Potency of Doxorubicin Immunoconjugates by King, H. Dalton, Yurgaitis, Derek, Willner, David, Firestone, Raymond A, Yang, Michael B, Lasch, Shirley J, Hellström, Karl Erik, Trail, Pamela A

“…Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to…”
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Antigen-specific activity of carcinoma-reactive BR64-doxorubicin conjugates evaluated in vitro and in human tumor xenograft models by TRAIL, P. A, WILLNER, D, LASCH, S. J, HENDERSON, A. J, GREENFIELD, R. S, KING, D, ZOECKLER, M. E, BRASLAWSKY, G. R

“…The anticarcinoma antibody BR64 was conjugated to a doxorubicin derivative, doxorubicin 13-[3-(2-pyridyldithio)propionyl]hydrazone, and the resulting…”
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Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity by Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A

“…The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a Lewisy-related, tumor-associated…”
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Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Peptide Linkers:  Inhibition of Aggregation by Methoxytriethyleneglycol Chains by King, H. Dalton, Dubowchik, Gene M, Mastalerz, Harold, Willner, David, Hofstead, Sandra J, Firestone, Raymond A, Lasch, Shirley J, Trail, Pamela A

“…High mole ratio BR96 immunoconjugates were synthesized using branched peptide−doxorubicin linkers designed to liberate doxorubicin following antigen-specific…”
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Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages by Dubowchik, Gene M, Radia, Shilpa, Mastalerz, Harold, Walker, Michael A, Firestone, Raymond A, Dalton King, H, Hofstead, Sandra J, Willner, David, Lasch, Shirley J, Trail, Pamela A

“…Bivalent doxorubicin (DOX)-dipeptides ( 16a– c) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases…”
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BR96 conjugates of highly potent anthracyclines by King, H.Dalton, Staab, Andrew J., Pham-Kaplita, Kahnie, Yurgaitis, Derek, Firestone, Raymond A., Lasch, Shirley J., Trail, Pamela A.

“…The 6-maleimidocaproylhydrazone derivatives of highly potent antitumor agents 5-Diacetoxypentyldoxorubicin and Morpholinodoxorubicin were synthesized and…”
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