Search Results - "Lary, C."

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases by Jucker, Mathias, Walker, Lary C.

“…Many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, are characterized by the progressive…”
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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases by Jucker, Mathias, Walker, Lary C.

“…The prion paradigm – the hypothesis that the seeded aggregation of certain proteins is key to understanding age-related neurodegenerative disorders – is…”
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Alzheimer's disease: From immunotherapy to immunoprevention by Jucker, Mathias, Walker, Lary C.

“…Recent Aβ-immunotherapy trials have yielded the first clear evidence that removing aggregated Aβ from the brains of symptomatic patients can slow the…”
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Neurodegenerative Diseases: Expanding the Prion Concept by Walker, Lary C, Jucker, Mathias

“…The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of many age-related neurodegenerative diseases. This paradigm holds that…”
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Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders by Jucker, Mathias, Walker, Lary C.

“…The misfolding and aggregation of specific proteins is a seminal occurrence in a remarkable variety of neurodegenerative disorders. In Alzheimer disease (the…”
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Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases by Walker, Lary C

“…Most age-related neurodegenerative diseases are associated with the misfolding and aberrant accumulation of specific proteins in the nervous system. The…”
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The Exceptional Vulnerability of Humans to Alzheimer’s Disease by Walker, Lary C, Jucker, Mathias

“…Like many humans, non-human primates deposit copious misfolded Aβ protein in the brain as they age. Nevertheless, the complete behavioral and pathologic…”
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The prion principle and Alzheimer's disease by Walker, Lary C, Jucker, Mathias

“…Similarities to molecular mechanisms underlying prion diseases may help to refine Alzheimer's disease therapies…”
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Evidence for iatrogenic transmission of Alzheimer’s disease by Jucker, Mathias, Walker, Lary C.

“…Credible evidence suggests that, under extraordinary circumstances, Alzheimer’s disease may be transmitted by a prion-like mechanism — yielding insights into…”
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Glial tauopathy: Neurons optional? by Walker, Lary C

“…In some neurodegenerative disorders, tau protein accumulates in astrocytes and/or oligodendrocytes, even though these glial cells produce much less of the…”
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Prion-like mechanisms in Alzheimer disease by Walker, Lary C

“…Senile plaques and neurofibrillary tangles are the principal histopathologic hallmarks of Alzheimer disease. The essential constituents of these lesions are…”
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Nonhuman primate models of Alzheimer-like cerebral proteopathy by Heuer, Eric, Rosen, Rebecca F, Cintron, Amarallys, Walker, Lary C

“…Nonhuman primates are useful for the study of age-associated changes in the brain and behavior in a model that is biologically proximal to humans. The Aβ and…”
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Aβ Plaques by Walker, Lary C

“…Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer's disease. Plaques are highly diverse structures;…”
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Mechanisms of protein seeding in neurodegenerative diseases by Walker, Lary C, Diamond, Marc I, Duff, Karen E, Hyman, Bradley T

“…Most age-associated neurodegenerative diseases involve the aggregation of specific proteins within the nervous system. In Alzheimer disease, the insidious…”
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Neurodegeneration: Amyloid-β pathology induced in humans by Jucker, Mathias, Walker, Lary C

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The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease by Walker, Lary C, Schelle, Juliane, Jucker, Mathias

“…Since the discovery that prion diseases can be transmitted to experimental animals by inoculation with afflicted brain matter, researchers have speculated that…”
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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease by Rasmussen, Jay, Mahler, Jasmin, Beschorner, Natalie, Kaeser, Stephan A., Häsler, Lisa M., Baumann, Frank, Nyström, Sofie, Portelius, Erik, Blennow, Kaj, Lashley, Tammaryn, Fox, Nick C., Sepulveda-Falla, Diego, Glatzel, Markus, Oblak, Adrian L., Ghetti, Bernardino, Nilsson, K. Peter R., Hammarström, Per, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias

“…The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes…”
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Sabotage by the brain's supporting cells by Walker, Lary C

“…Disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (also known as motor neuron disease) are each defined by a core…”
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Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases by Walker, Lary C., LeVine, Harry

“…With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant…”
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Sabotage by the brain’s supporting cells helps fuel neurodegeneration by Walker, Lary C.

“…Several neurodegenerative disorders are linked to the build-up of abnormal α-synuclein protein in distinct cell types. It emerges that differing intracellular…”
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