Search Results - "Larue, Valery"

The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101 by El Meshri, Salah Edin, Boutant, Emmanuel, Mouhand, Assia, Thomas, Audrey, Larue, Valéry, Richert, Ludovic, Vivet-Boudou, Valérie, Mély, Yves, Tisné, Carine, Muriaux, Delphine, de Rocquigny, Hugues

“…HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with RNA, and the p6…”
Get full text

Investigation of RNA-Ligand Interactions by 19F NMR Spectroscopy Using Fluorinated Probes by Lombès, Thomas, Moumné, Roba, Larue, Valéry, Prost, Elise, Catala, Marjorie, Lecourt, Thomas, Dardel, Frédéric, Micouin, Laurent, Tisné, Carine

“…Spy swap: The interaction between an unlabeled RNA and unlabeled ligands (red hexagon) can be monitored by 19F NMR spectroscopy using small fluorinated…”
Get full text

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis by Mouhand, Assia, Belfetmi, Anissa, Catala, Marjorie, Larue, Valéry, Zargarian, Loussiné, Brachet, Franck, Gorelick, Robert J, Van Heijenoort, Carine, Mirambeau, Gilles, Barraud, Pierre, Mauffret, Olivier, Tisné, Carine

“…Abstract During HIV-1 assembly and budding, Gag protein, in particular the C-terminal domain containing the nucleocapsid domain (NCd), p1 and p6, is the site…”
Get full text

The structure of “defective in induced resistance” protein of Arabidopsis thaliana, DIR1, reveals a new type of lipid transfer protein by Lascombe, Marie‐Bernard, Bakan, Bénédicte, Buhot, Nathalie, Marion, Didier, Blein, Jean‐Pierre, Larue, Valéry, Lamb, Chris, Prangé, Thierry

“…Screening of transfer DNA (tDNA) tagged lines of Arabidopsis thaliana for mutants defective in systemic acquired resistance led to the characterization of…”
Get full text

Structure-Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-Bromo-1H-indole-3-acetohydroxamic Acid by Petit, Sylvain, Duroc, Yann, Larue, Valéry, Giglione, Carmela, Léon, Carole, Soulama, Coralie, Denis, Alexis, Dardel, Frédéric, Meinnel, Thierry, Artaud, Isabelle

“…SAR by NMR: A series of indole compounds derived from 5‐bromo‐1H‐indole‐3‐acetohydroxamic acid were synthesized. Their inhibitory activities were evaluated…”
Get full text

New peptide deformylase inhibitors and cooperative interaction: a combination to improve antibacterial activity by GOEMAERE, Emilie, MELET, Armelle, MEINNEL, Thierry, DARDEL, Frederic, ARTAUD, Isabelle, PAGES, Jean-Marie, LARUE, Valéry, LIEUTAUD, Aurélie, DE SOUSA, Rodolphe Alves, CHEVALIER, Jacqueline, YIMGA-DJAPA, Liselotte, GIGLIONE, Carmela, HUGUET, Florian, ALIMI, Mickael

“…Bacterial drug resistance is a worrying public health problem and there is an urgent need for research and development to provide new antibacterial molecules…”
Get full text

The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag by Chen, Xiaowei, Coric, Pascale, Larue, Valery, Turcaud, Serge, Wang, Xiao, Nonin-Lecomte, Sylvie, Bouaziz, Serge

“…During the maturation of HIV-1 particle, the Gag polyprotein is cleaved into several proteins by the HIV-1 protease. These proteins rearrange to form…”
Get full text

Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates by Piton, Jérémie, Larue, Valéry, Thillier, Yann, Dorléans, Audrey, Pellegrini, Olivier, de la Sierra-Gallay, Inés Li, Vasseur, Jean-Jacques, Debart, Françoise, Tisné, Carine, Condon, Ciarán

“…The initiation of mRNA degradation often requires deprotection of its 5′ end. In eukaryotes, the 5′-methylguanosine (cap) structure is principally removed by…”
Get full text

Fragment-based design of small RNA binders: Promising developments and contribution of NMR by Moumné, Roba, Catala, Marjorie, Larue, Valéry, Micouin, Laurent, Tisné, Carine

“…Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In…”
Get full text

Solution conformation of an RNA–DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand by Hantz, Edith, Larue, Valery, Ladam, Patrick, Le Moyec, Laurence, Gouyette, Catherine, Huynh Dinh, Tam

“…RNA–DNA hybrid duplexes are involved in transcription, replication and reverse transcription of nucleic acids. Information on such duplexes may shed some light…”
Get full text

Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors by Boularot, Adrien, Giglione, Carmela, Petit, Sylvain, Duroc, Yann, Alves de Sousa, Rodolphe, Larue, Valéry, Cresteil, Thierry, Dardel, Frédéric, Artaud, Isabelle, Meinnel, Thierry

“…New classes of antibiotics are urgently needed to counter increasing levels of pathogen resistance. Peptide deformylase (PDF) was originally selected as a…”
Get full text

Characterization of RNA binding and chaperoning activities of HIV-1 Vif protein: Importance of the C-terminal unstructured tail by Sleiman, Dona, Bernacchi, Serena, Xavier Guerrero, Santiago, Brachet, Franck, Larue, Valéry, Paillart, Jean-Christophe, Tisné, Carine

“…The viral infectivity factor (Vif) is essential for the productive infection and dissemination of HIV-1 in non-permissive cells, containing the cellular…”
Get full text

Backbone resonance assignments of the m1A22 tRNA methyltransferase TrmK from Bacillus subtilis by Dégut, Clément, Barraud, Pierre, Larue, Valéry, Tisné, Carine

“…RNA modification is a post-transcriptional process by which certain nucleotides are altered after their initial incorporation into an RNA chain. Transfer RNAs…”
Get full text

Magnetic resonance spectroscopy of cellular lipid extracts from sensitive, resistant and reverting K562 cells and flow cytometry for investigating the P-glycoprotein function in resistance reversion by Le Moyec, Laurence, Legrand, Ollivier, Larue, Valery, Kawakami, Mutsumi, Marie, Jean Pierre, Calvo, Fabien, Hantz, Edith, Taillandier, Eliane

“…The proton NMR spectra of K562 cells contain resonances of lipids. When these cells acquire multidrug resistance phenotype, the NMR lipid signals are modified…”
Get full text

Investigation of RNA-Ligand Interactions by super(19)FNMR Spectroscopy Using Fluorinated Probes by Lombes, Thomas, Moumne, Roba, Larue, Valery, Prost, Elise, Catala, Marjorie, Lecourt, Thomas, Dardel, Frederic, Micouin, Laurent, Tisne, Carine

“…Spy swap: The interaction between an unlabeled RNA and unlabeled ligands (red hexagon) can be monitored by super(19)FNMR spectroscopy using small fluorinated…”
Get full text

The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling by Moncoq, Karine, Broutin, Isabelle, Larue, Valéry, Perdereau, Dominique, Cailliau, Katia, Browaeys-Poly, Edith, Burnol, Anne-Françoise, Ducruix, Arnaud

“…Grb14 belongs to the Grb7 family of adapter proteins and was identified as a negative regulator of insulin signal transduction. Its inhibitory effect on the…”
Get full text

Aminoglycoside and glycopeptide renal toxicity in intensive care patients studied by proton magnetic resonance spectroscopy of urine by Le Moyec, Laurence, Racine, Stéphane, Le Toumelin, Philippe, Adnet, Frédéric, Larue, Valéry, Cohen, Yves, Leroux, Yves, Cupa, Michel, Hantz, Edith

“…OBJECTIVEAminoglycoside and glycopeptide antibiotics are responsible for renal toxicity. In most cases, the nephrotoxicity is limited to a reversible tubular…”
Get full text

Solution conformation of α, β or γ-methylglutamyl-containing derivatives as probes of vitamin K-dependent carboxylase using molecular modelling and nuclear magnetic resonance by Larue, Valery, Gharbi-Benarous, Josyane, Acher, Francine, Arulmozhi, Veerappan, Tisné, Carine, Todeschi, Nathalie, Azerad, Robert, Girault, Jean-Pierre

“…In the present study, the conformational behaviour of methyl substituted N-BOC glutamic acid methyl esters (2M, 3T, 3E, 4T, 4E) has been completely…”
Get full text

Synthesis of New Phosphonated Tripod Ligands as Putative New Therapeutic Agents in the Chelation Treatment of Metal Intoxications by Burgada, Ramon, Bailly, Theodorine, Lecouvey, Marc, Larue, Valery, Leroux, Yves

“…In a quest for new chelation therapy drugs for the treatment of intoxication by actinides, some new phosphonated chelating tripod ligands have been…”
Get full text

Structural characterization of B. subtilis m1A22 tRNA methyltransferase TrmK: insights into tRNA recognition by Dégut, Clément, Roovers, Martine, Barraud, Pierre, Brachet, Franck, Feller, André, Larue, Valéry, Al Refaii, Abdalla, Caillet, Joël, Droogmans, Louis, Tisné, Carine

“…Abstract 1-Methyladenosine (m1A) is a modified nucleoside found at positions 9, 14, 22 and 58 of tRNAs, which arises from the transfer of a methyl group onto…”
Get full text