Search Results - "Larsson, Connie A"

The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome by Larsson, Connie A, Cote, Gilbert, Quintás-Cardama, Alfonso

“…Over the past few years, large-scale genomic studies of patients with myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML) have unveiled…”
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Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity by Pant, Vinod, Xiong, Shunbin, Wasylishen, Amanda R., Larsson, Connie A., Aryal, Neeraj K., Chau, Gilda, Tailor, Ramesh C., Lozano, Guillermina

“…Gastrointestinal (GI) syndrome is a serious side effect and doselimiting toxicity observed in patients undergoing lower-abdominal radiotherapy. Previous mouse…”
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Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration by Larsson, Connie A., Moyer, Sydney M., Liu, Bin, Michel, Keith A., Pant, Vinod, Yang, Peirong, Wong, Justin, El-Naggar, Adel K., Krahe, Ralf, Lozano, Guillermina

“…TP53 mutations occur in ∼50% of all human tumors, with increased frequency in aggressive cancers that are notoriously difficult to treat. Additionally, p53…”
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Tumorigenesis promotes Mdm4-S overexpression by Pant, Vinod, Larsson, Connie A, Aryal, Neeraj, Xiong, Shunbin, You, M James, Quintas-Cardama, Alfonso, Lozano, Guillermina

“…Disruption of the p53 tumor suppressor pathway is a primary cause of tumorigenesis. In addition to mutation of the p53 gene itself, overexpression of major…”
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Mdm proteins: critical regulators of embryogenesis and homoeostasis by Moyer, Sydney M., Larsson, Connie A., Lozano, Guillermina

“…Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancer-related studies. A multitude of…”
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Mdm proteins： critical regulators of embryogenesis and hornoeostasis by Sydney M. Moyer Connie A. Larsson Guillermina Lozano

“…Mdm2 and Mdm4 are negative regulators of the tumour suppressor p53; hence, this relationship is the focus of many cancerrelated studies. A multitude of…”
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Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes by Ortiz, G J, Li, Y, Post, S M, Pant, V, Xiong, S, Larsson, C A, El-Naggar, A K, Johnson, D G, Lozano, G

“…MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor suppressor and is elevated in many human cancers that retain wild-type p53. MDM2 SNP309G…”
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Mdm proteins: critical regulators of embry ogenesis and homeostasis by Moyer, Sydney M, Larsson, Connie A, Lozano, Guillermina

“…Mdm2 and Mdm4 are negative regulators of the tumor suppressor p53; hence, this relationship is the focus of many cancer related studies. A multitude of…”
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BET Bromodomain Inhibition Reduces Leukemic Burden and Prolongs Survival In The Eμ-TCL1 Transgenic Mouse Model Of Chronic Lymphocytic Leukemia (CLL) Independent Of TP53 Mutation Status by Larsson, Connie A, Kojima, Kensuke, Wang, Yong, Navin, Nicholas, Gallardo, Miguel, Primo, Daniel, Rojas, Jose L., Martinez, Joaquin, Manshouri, Taghi, Lee, Hun Ju, Bradner, James E, Ballesteros, Juan, Post, Sean M., Lozano, Guillermina (Gigi), Quintás-Cardama, Alfonso

“…Inhibition of Brd4, a bromodomain and extra-terminal (BET) protein, results in antiproliferative effects and terminal differentiation in the MYC-driven B-cell…”
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