Search Results - "Larsen, Nicolai B"

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts by Larsen, Nicolai B., Gao, Alan O., Sparks, Justin L., Gallina, Irene, Wu, R. Alex, Mann, Matthias, Räschle, Markus, Walter, Johannes C., Duxin, Julien P.

“…DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the…”
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Dynamics of the Eukaryotic Replicative Helicase at Lagging-Strand Protein Barriers Support the Steric Exclusion Model by Kose, Hazal B., Larsen, Nicolai B., Duxin, Julien P., Yardimci, Hasan

“…Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG…”
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PARP1-dependent DNA-protein crosslink repair by Fábián, Zita, Kakulidis, Ellen S., Hendriks, Ivo A., Kühbacher, Ulrike, Larsen, Nicolai B., Oliva-Santiago, Marta, Wang, Junhui, Leng, Xueyuan, Dirac-Svejstrup, A. Barbara, Svejstrup, Jesper Q., Nielsen, Michael L., Caldecott, Keith, Duxin, Julien P.

“…DNA-protein crosslinks (DPCs) are toxic lesions that inhibit DNA related processes. Post-translational modifications (PTMs), including SUMOylation and…”
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Stalled replication forks generate a distinct mutational signature in yeast by Larsen, Nicolai B., Liberti, Sascha E., Vogel, Ivan, Jørgensen, Signe W., Hickson, Ian D., Mankouri, Hocine W.

“…Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in…”
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Esc2 promotes telomere stability in response to DNA replication stress by Jørgensen, Signe W, Liberti, Sascha E, Larsen, Nicolai B, Lisby, Michael, Mankouri, Hocine W, Hickson, Ian D

“…Abstract Telomeric regions of the genome are inherently difficult-to-replicate due to their propensity to generate DNA secondary structures and form…”
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The Escherichia coli Tus–Ter replication fork barrier causes site-specific DNA replication perturbation in yeast by Larsen, Nicolai B., Sass, Ehud, Suski, Catherine, Mankouri, Hocine W., Hickson, Ian D.

“…Replication fork (RF) pausing occurs at both ‘programmed’ sites and non-physiological barriers (for example, DNA adducts). Programmed RF pausing is required…”
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The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair by Sparks, Justin L., Chistol, Gheorghe, Gao, Alan O., Räschle, Markus, Larsen, Nicolai B., Mann, Matthias, Duxin, Julien P., Walter, Johannes C.

“…Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten genome integrity. Using Xenopus egg extracts, we previously showed…”
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Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway by Liu, Julio C Y, Kühbacher, Ulrike, Larsen, Nicolai B, Borgermann, Nikoline, Garvanska, Dimitriya H, Hendriks, Ivo A, Ackermann, Leena, Haahr, Peter, Gallina, Irene, Guérillon, Claire, Branigan, Emma, Hay, Ronald T, Azuma, Yoshiaki, Nielsen, Michael Lund, Duxin, Julien P, Mailand, Niels

“…DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically…”
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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis by Gallina, Irene, Hendriks, Ivo A., Hoffmann, Saskia, Larsen, Nicolai B., Johansen, Joachim, Colding-Christensen, Camilla S., Schubert, Lisa, Sellés-Baiget, Selene, Fábián, Zita, Kühbacher, Ulrike, Gao, Alan O., Räschle, Markus, Rasmussen, Simon, Nielsen, Michael L., Mailand, Niels, Duxin, Julien P.

“…Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These…”
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Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery by Krakovka, Sascha, Ranjbarian, Farahnaz, Luján, Lucas A., Saura, Alicia, Larsen, Nicolai B., Jiménez-González, Alejandro, Reggenti, Anna, Luján, Hugo D., Svärd, Staffan G., Hofer, Anders

“…Giardiasis is a diarrheal disease caused by the unicellular parasite Giardia intestinalis, for which metronidazole is the main treatment option. The parasite…”
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Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1 by Bocquet, Nicolas, Bizard, Anna H, Abdulrahman, Wassim, Larsen, Nicolai B, Faty, Mahamadou, Cavadini, Simone, Bunker, Richard D, Kowalczykowski, Stephen C, Cejka, Petr, Hickson, Ian D, Thomä, Nicolas H

“…The 'dissolvasome', composed of TopIIIα, BLM and RMI proteins, coordinates DNA-helicase and DNA-topoisomerase activities to resolve double Holliday junctions…”
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A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation by Larsen, Nicolai B, Hickson, Ian D, Mankouri, Hocine W

“…Site-specific arrest of DNA replication is a useful tool for analyzing cellular responses to DNA replication perturbation. The E. coli Tus-Ter replication…”
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Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes by Larsen, Nicolai B, Hickson, Ian D, Mankouri, Hocine W

“…The high-affinity binding of the Tus protein to specific 21-bp sequences, called Ter, causes site-specific, and polar, DNA replication fork arrest in E coli…”
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Giardia intestinalis thymidine kinase: a high-affinity enzyme crucial for DNA synthesis and an Achilles heel exploitable for drug discovery by Krakovka, Sascha, Ranjbarian, Farahnaz, Luján, Lucas A., Saura, Alicia, Larsen, Nicolai B., Jiménez-González, Alejandro, Regenti, Anna, Luján, Hugo D., Svärd, Staffan G., Hofer, Anders

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Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase III[alpha] and RMI1 by Bocquet, Nicolas, Bizard, Anna H, Abdulrahman, Wassim, Larsen, Nicolai B, Faty, Mahamadou, Cavadini, Simone, Bunker, Richard D, Kowalczykowski, Stephen C, Cejka, Petr, Hickson, Ian D, Thomä, Nicolas H

“…Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require enzymatic separation. Topoisomerase…”
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Histamine immunoreactive axons in the macaque retina by Gastinger, MJ, O'Brien, JJ, Larsen, NB, Marshak, DW

“…The goal of these experiments was to identify the neurotransmitter in centrifugal axons of the macaque retina. Macaca mulatta retinas and optic nerves were…”
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Diabetic retinopathy--new challenges by Larsen, Jens Nicolai B, Sjølie, Anne Katrin

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