Search Results - "Larsen, Mads Delbo"
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Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination
Published in Nature communications (05-10-2021)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs)…”
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Evasion of Classical Complement Pathway Activation on Plasmodium falciparum -Infected Erythrocytes Opsonized by PfEMP1-Specific IgG
Published in Frontiers in immunology (07-01-2019)“…Members of the PfEMP1 protein family are expressed on the surface of -infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are…”
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Immunoassay for quantification of antigen-specific IgG fucosylation
Published in EBioMedicine (01-07-2022)“…BACKGROUNDImmunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly…”
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No sweet deal: the antibody-mediated immune response to malaria
Published in Trends in parasitology (01-06-2022)“…IgG antibodies are key effector molecules in acquired immunity to Plasmodium falciparum malaria, and the PfEMP1 adhesins expressed on the surface of the…”
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Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity
Published in Trends in immunology (01-10-2022)“…Healthy immune responses require efficient protection without excessive inflammation. Recent discoveries on the degree of fucosylation of a human N-linked…”
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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
Published in Science (American Association for the Advancement of Science) (26-02-2021)“…Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is…”
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IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax
Published in Infection and immunity (01-08-2018)“…Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the erythrocyte membrane protein 1 (PfEMP1) family of clonally…”
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Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level
Published in Immunology (01-03-2024)“…The type and strength of effector functions mediated by immunoglobulin G (IgG) antibodies rely on the subclass and the composition of the N297 glycan…”
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Malaria parasite evasion of classical complement pathway attack
Published in Molecular immunology (01-09-2017)Get full text
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The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees
Published in EBioMedicine (01-01-2023)“…Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically…”
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The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccineesResearch in context
Published in EBioMedicine (01-01-2023)“…Background: Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses,…”
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