Search Results - "Larsen, Christian Jacques"

Human ARF binds E2F1 and inhibits its transcriptional activity by EYMIN, Béatrice, KARAYAN, Lucie, SEITE, Paule, BRAMBILLA, Christian, BRAMBILLA, Elisabeth, LARSEN, Christian-Jacques, GAZZERI, Sylvie

“…The INK4a/ARF locus which is frequently inactivated in human tumours encodes two different tumour suppressive proteins, p16(INK4a) and ARF. p16(INK4a) is a…”
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Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes by AYRAULT, Olivier, ANDRIQUE, Laetitia, LARSEN, Christian-Jacques, SEITE, Paule

“…The tumor suppressor Arf (Alternative Reading Frame) protein (p14ARF in human and p19ARF in mouse) is mainly located in the nucleolus consistent with its…”
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Human ARF protein interacts with topoisomerase I and stimulates its activity by KARAYAN, Lucie, RIOU, Jean-Francois, SEITE, Paule, MIGEON, Julien, CANTEREAU, Anne, LARSEN, Christian-Jacques

“…The ARF gene (p19(ARF) in mouse and p14(ARF) in man) has become a central actor of the cell cycle regulation process as it participates to the ARF-MDM2-p53…”
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In vitro and in vivo analysis of the interaction between 5.8S rRNA and ARF protein reveal a new difference between murine p19ARF and human p14ARF by ANDRIQUE, Laëtitia, AYRAULT, Olivier, LARSEN, Christian-Jacques, SEITE, Paule

“…Both human and murine ARF proteins have been recently reported to impair rRNA maturation and ribosomes biogenesis through a p53-independent pathway. A specific…”
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Cannibalisme et dormance des cellules cancéreuses humaines by Larsen, Christian-Jacques

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La colonisation métastatique du foie par des cellules de tumeurs colorectales est supprimée par deux micro-RNAs cellulaires (miR-483-5p et miR-551a) by Larsen, Christian-Jacques

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Quand gliomes riment avec exosomes by Larsen, Christian-Jacques

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Tribunes libres et débats transversaux by Larsen, Christian-Jacques

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La technologie CRISPR-Cas9 : une des clés des thérapies personnalisées ? by Larsen, Christian-Jacques

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Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I by AYRAULT, Olivier, KARAYAN, Lucie, RIOU, Jean-Francois, LARSEN, Christian-Jacques, SEITE, Paule

“…We recently reported an interaction between the p14(ARF) protein and human topoisomerase I (Topo I) resulting in the stimulation of the relaxation activity of…”
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La culture ex vivo de cellules tumorales circulantes : un réel espoir de thérapeutique personnalisée? by Larsen, Christian-Jacques

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Les mécanismes épigénétiques à l’œuvre dans les gliomes pédiatriques by Larsen, Christian-Jacques

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P16INK4A is implicated in both the immediate and adaptative response of human keratinocytes to UVB irradiation by CHAZAL, Marjorie, MARIONNET, Claire, MICHEL, Laurence, MOLLIER, Karine, DAZARD, Jean-Eudes, DELLA VALLE, Véronique, LARSEN, Christian-Jacques, GRAS, Marie-Pierre, BASSET-SEGUIN, Nicole

“…The p16(INK4A-ARF) locus plays a crucial role in the control of cellular proliferation via both the Rb and P53 pathways. We previously demonstrated that this…”
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Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias by Bernard, O, Guglielmi, P, Jonveaux, P, Cherif, D, Gisselbrecht, S, Mauchauffe, M, Berger, R, Larsen, C J, Mathieu-Mahul, D

“…Molecular study of a t(1;14)(p32;q11) translocation found in an acute T-cell leukemia (Kd cells) with a relatively mature phenotype is reported. Complex DNA…”
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L’intrication des voies métaboliques dans la progression tumorale by Larsen, Christian-Jacques

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Le (R)-2-hydroxyglutarate ou (R)-2HG est bien un oncométabolite by Larsen, Christian-Jacques

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Modèles d’oncogenèse : un monde sans fin ? by Larsen, Christian-Jacques

“…Nos connaissances de la biologie des tumeurs ont bénéficié à la fin du xxe siècle de l’apport de la génétique (oncogènes, gènes suppresseurs de tumeur,…”
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L’histone désacétylase SIRT6 : un gène suppresseur au potentiel thérapeutique excitant by Larsen, Christian-Jacques

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Le 2-hydroxyglutarate (2-HG) produit par la mutation R132 d'IDH1 inhibe la déméthylation de l'histone H3 qui est requise pour la différenciation cellulaire by Larsen, Christian-Jacques

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Les mutations des gènes IDH1 et 2 dans les gliomes conditionnent l'acquisition d'un phénotype « hyperméthylateur » au sein des tumeurs by Larsen, Christian-Jacques

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