Search Results - "Larsen, CP"

The CD40 pathway in allograft rejection, acceptance, and tolerance by Larsen, Christian P, Pearson, Thomas C

“…The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling…”
Get full text

Long‐term survival of pig‐to‐rhesus macaque renal xenografts is dependent on CD4 T cell depletion by Kim, Steven C., Mathews, David V., Breeden, Cynthia P., Higginbotham, Laura B., Ladowski, Joseph, Martens, Gregory, Stephenson, Allison, Farris, Alton B., Strobert, Elizabeth A., Jenkins, Joe, Walters, Eric M., Larsen, Christian P., Tector, Matthew, Tector, Alfred J., Adams, Andrew B.

“…The shortage of available organs remains the greatest barrier to expanding access to transplant. Despite advances in genetic editing and immunosuppression,…”
Get full text

Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long‐Term Renal Allograft Function by Adams, A. B., Goldstein, J., Garrett, C., Zhang, R., Patzer, R. E., Newell, K. A., Turgeon, N. A., Chami, A. S., Guasch, A., Kirk, A. D., Pastan, S. O., Pearson, T. C., Larsen, C. P.

“…Belatacept, a T cell costimulation blocker, demonstrated superior renal function, lower cardiovascular risk, and improved graft and patient survival in renal…”
Get full text

Diagnosis of IgG4-Related Tubulointerstitial Nephritis by RAISSIAN, Yassaman, NASR, Samih H, SETHI, Sanjeev, FIDLER, Mary E, CORNELL, Lynn D, LARSEN, Christopher P, COLVIN, Robert B, SMYRK, Thomas C, TAKAHASHI, Naoki, BHALODIA, Ami, SOHANI, Aliyah R, LIZHI ZHANG, CHARI, Suresh

“…IgG4-related systemic disease is an autoimmune disease that was first recognized in the pancreas but also affects other organs. This disease may manifest as…”
Get full text

Membranous glomerulonephritis is a manifestation of IgG4-related disease by Alexander, Mariam P, Larsen, Christopher P, Gibson, Ian W, Nasr, Samih H, Sethi, Sanjeev, Fidler, Mary E, Raissian, Yassaman, Takahashi, Naoki, Chari, Suresh, Smyrk, Thomas C, Cornell, Lynn D

“…IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that typically manifests as fibro-inflammatory masses that can affect nearly any organ…”
Get more information

Migration patterns of dendritic leukocytes. Implications for transplantation by Austyn, J M, Larsen, C P

Get more information

Belatacept‐Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells by Mathews, D. V., Wakwe, W. C., Kim, S. C., Lowe, M. C., Breeden, C., Roberts, M. E., Farris, A. B., Strobert, E. A., Jenkins, J. B., Larsen, C. P., Ford, M. L., Townsend, R., Adams, A. B.

“…Recently, newer therapies have been designed to more specifically target rejection in an effort to improve efficacy and limit unwanted toxicity. Belatacept, a…”
Get full text

Five-Year Safety and Efficacy of Belatacept in Renal Transplantation by VINCENTI, Flavio, BLANCHO, Gilles, NASHAN, Björn, SOULILLOU, Jean-Paul, VANRENTERGHEM, Yves, WEKERLE, Thomas, AGARWAL, Mamta, GUJRATHI, Sheila, JINSHAN SHEN, SHI, Rebecca, TOWNSEND, Robert, CHARPENTIER, Bernard, DURRBACH, Antoine, FRIEND, Peter, GRINYO, Josep, HALLORAN, Philip F, KLEMPNAUER, Jurgen, LANG, Philippe, LARSEN, Christian P, MÜHLBACHER, Ferdinand

“…Belatacept is a first-in-class co-stimulation blocker in development for primary maintenance immunosuppression. A Phase II study comparing belatacept with…”
Get full text

Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and Function by Thompson, P., Badell, I. R., Lowe, M., Cano, J., Song, M., Leopardi, F., Avila, J., Ruhil, R., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Iwakoshi, N., Larsen, C. P., Kirk, A. D.

“…Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although…”
Get full text

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways by Rajotte, Ray V, Larsen, Christian P, Cardona, Kenneth, Korbutt, Gregory S, Milas, Zvonimir, Lyon, James, Cano, Jose, Jiang, Wanhong, Bello-Laborn, Hameeda, Hacquoil, Brad, Strobert, Elizabeth, Gangappa, Shivaprakash, Weber, Collin J, Pearson, Thomas C

“…We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets…”
Get full text

An Integrated Safety Profile Analysis of Belatacept in Kidney Transplant Recipients by GRINYO, Josep, CHARPENTIER, Bernard, LARSEN, Christian P, MEDINA PESTANA, José, VANRENTERGHEM, Yves, VINCENTI, Flavio, REYES-ACEVEDO, Rafael, APANOVITCH, Anne Marie, GUJRATHI, Sheila, AGARWAL, Mamta, THOMAS, Dolca

“…Belatacept is associated with better renal function and an improved cardiovascular/metabolic risk profile versus cyclosporine in kidney transplant recipients…”
Get full text

A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival by Lowe, M., Badell, I. R., Thompson, P., Martin, B., Leopardi, F., Strobert, E., Price, A. A., Abdulkerim, H. S., Wang, R., Iwakoshi, N. N., Adams, A. B., Kirk, A. D., Larsen, C. P., Reimann, K. A.

“…The importance of CD40/CD154 costimulatory pathway blockade in immunosuppression strategies is well‐documented. Efforts are currently focused on monoclonal…”
Get full text

Heterologous immunity provides a potent barrier to transplantation tolerance by Adams, Andrew B, Williams, Matthew A, Jones, Thomas R, Shirasugi, Nozomu, Durham, Megan M, Kaech, Susan M, Wherry, E John, Onami, Thandi, Lanier, J Gibson, Kokko, Kenneth E, Pearson, Thomas C, Ahmed, Rafi, Larsen, Christian P

“…Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman…”
Get full text

Heterologous immunity: an overlooked barrier to tolerance by Adams, Andrew B., Pearson, Thomas C., Larsen, Christian P.

“…In less than 50 years the field of organ transplantation has transitioned from an experimental concept to clinical commonplace. Notwithstanding the dramatic…”
Get full text

Alternative Immunomodulatory Strategies for Xenotransplantation: CD40/154 Pathway‐Sparing Regimens Promote Xenograft Survival by Thompson, P., Badell, I. R., Lowe, M., Turner, A., Cano, J., Avila, J., Azimzadeh, A., Cheng, X., Pierson III, R. N., Johnson, B., Robertson, J., Song, M., Leopardi, F., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Larsen, C. P., Kirk, A. D.

“…Immunosuppressive therapies that block the CD40/CD154 costimulatory pathway have proven to be uniquely effective in preclinical xenotransplant models. Given…”
Get full text

An Anti‐CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA‐4 Ig by Pinelli, D. F., Wagener, M. E., Liu, D., Yamniuk, A., Tamura, J., Grant, S., Larsen, C. P., Suri, A., Nadler, S. G., Ford, M. L.

“…The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but…”
Get full text

Pathogen Stimulation History Impacts Donor‐Specific CD8+ T Cell Susceptibility to Costimulation/Integrin Blockade–Based Therapy by Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A. E., Larsen, C. P., Ford, M. L.

“…Recent studies have shown that the quantity of donor‐reactive memory T cells is an important factor in determining the relative heterologous immunity barrier…”
Get full text

A New Look at Blockade of T‐cell Costimulation: A Therapeutic Strategy for Long‐term Maintenance Immunosuppression by Larsen, C. P., Knechtle, S. J., Adams, A., Pearson, T., Kirk, A. D.

“…Activated T cells orchestrate the immune response that results in graft rejection; therefore, a common goal among current immunosuppressive therapies is to…”
Get full text

Experience with a Novel Efalizumab‐Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation by Turgeon, N. A., Avila, J. G., Cano, J. A., Hutchinson, J. J., Badell, I. R., Page, A. J., Adams, A. B., Sears, M. H., Bowen, P. H., Kirk, A. D., Pearson, T. C., Larsen, C. P.

“…Islet transplantation is an experimental therapy for selected patients with type 1 diabetes (T1DM). It remains limited by immunosuppressive drug toxicity,…”
Get full text

Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival by Adams, Andrew B, Shirasugi, Nozomu, Jones, Thomas R, Durham, Megan M, Strobert, Elizabeth A, Cowan, Shannon, Rees, Phyllis, Hendrix, Rose, Price, Karen, Kenyon, Norma S, Hagerty, David, Townsend, Robert, Hollenbaugh, Dianne, Pearson, Thomas C, Larsen, Christian P

“…In recent years, reagents have been developed that specifically target signals critical for effective T cell activation and function. Manipulation of the…”
Get full text