Search Results - "Larsen, C.P"

Three‐Year Outcomes from BENEFIT, a Randomized, Active‐Controlled, Parallel‐Group Study in Adult Kidney Transplant Recipients by Vincenti, F., Larsen, C. P., Alberu, J., Bresnahan, B., Garcia, V. D., Kothari, J., Lang, P., Urrea, E. Mancilla, Massari, P., Mondragon‐Ramirez, G., Reyes‐Acevedo, R., Rice, K., Rostaing, L., Steinberg, S., Xing, J., Agarwal, M., Harler, M. B., Charpentier, B.

“…The clinical profile of belatacept in kidney transplant recipients was evaluated to determine if earlier results in the BENEFIT study were sustained at 3…”
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Fc‐Silent Anti‐CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection by Kim, S. C., Wakwe, W., Higginbotham, L. B., Mathews, D. V., Breeden, C. P., Stephenson, A. C., Jenkins, J., Strobert, E., Price, K., Price, L., Kuhn, R., Wang, H., Yamniuk, A., Suchard, S., Farris, A. B., Pearson, T. C., Larsen, C. P., Ford, M. L., Suri, A., Nadler, S., Adams, A. B.

“…The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective…”
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Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half‐Life and Phenotype After Adoptive Transfer by Singh, K., Stempora, L., Harvey, R. D., Kirk, A. D., Larsen, C. P., Blazar, B. R., Kean, L. S.

“…Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their…”
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CD40‐Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates by Thompson, P., Cardona, K., Russell, M., Badell, I. R., Shaffer, V., Korbutt, G., Rayat, G. R., Cano, J., Song, M., Jiang, W., Strobert, E., Rajotte, R., Pearson, T., Kirk, A. D., Larsen, C. P.

“…The widespread clinical implementation of alloislet transplantation as therapy for type 1 diabetes has been hindered by the lack of suitable islet donors…”
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Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and Function by Thompson, P., Badell, I. R., Lowe, M., Cano, J., Song, M., Leopardi, F., Avila, J., Ruhil, R., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Iwakoshi, N., Larsen, C. P., Kirk, A. D.

“…Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although…”
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High CTLA‐4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA‐4 Coinhibition and Resistance to Belatacept by Krummey, S. M., Cheeseman, J. A., Conger, J. A., Jang, P. S., Mehta, A. K., Kirk, A. D., Larsen, C. P., Ford, M. L.

“…The CD28/cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high…”
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An Anti‐CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA‐4 Ig by Pinelli, D. F., Wagener, M. E., Liu, D., Yamniuk, A., Tamura, J., Grant, S., Larsen, C. P., Suri, A., Nadler, S. G., Ford, M. L.

“…The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but…”
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Nondepleting Anti‐CD40‐Based Therapy Prolongs Allograft Survival in Nonhuman Primates by Badell, I. R., Thompson, P. W., Turner, A. P., Russell, M. C., Avila, J. G., Cano, J. A., Robertson, J. M., Leopardi, F. V., Strobert, E. A., Iwakoshi, N. N., Reimann, K. A., Ford, M. L., Kirk, A. D., Larsen, C. P.

“…Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has…”
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Dual Islet Transplantation Modeling of the Instant Blood‐Mediated Inflammatory Reaction by Martin, B. M., Samy, K. P., Lowe, M. C., Thompson, P. W., Cano, J., Farris, A. B., Song, M., Dove, C. R., Leopardi, F. V., Strobert, E. A., Jenkins, J. B., Collins, B. H., Larsen, C. P., Kirk, A. D.

“…Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet…”
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CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8 by Badell, I. R., Russell, M. C., Cardona, K., Shaffer, V. O., Turner, A. P., Avila, J. G., Cano, J. A., Leopardi, F. V., Song, M., Strobert, E. A., Ford, M. L., Pearson, T. C., Kirk, A. D., Larsen, C. P.

“…Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization…”
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Transplant Tolerance in Non‐Human Primates: Progress, Current Challenges and Unmet Needs by Kean, L. S., Gangappa, S., Pearson, T. C., Larsen, C. P.

“…Given the significant morbidity associated with current post‐transplant immunosuppressive regimens, induction of immune tolerance continues to be an important…”
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Clinicopathologic Features of Membranous-Like Glomerulopathy With Masked IgG Kappa Deposits by Larsen, C P, Boils, C L, Cossey, L N, Sharma, S G, Walker, P D

“…Ig deposits identified on renal biopsy samples by paraffin immunofluorescence that show negative staining by routine immunofluorescence on frozen tissue have…”
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A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival by LOWE, M, BADELL, I. R, ADAMS, A. B, KIRK, A. D, LARSEN, C. P, REIMANN, K. A, THOMPSON, P, MARTIN, B, LEOPARDI, F, STROBERT, E, PRICE, A. A, ABDULKERIM, H. S, WANG, R, IWAKOSHI, N. N

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Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole‐Blood Chimerism in Rhesus Macaques by Ramakrishnan, S. K., Page, A., Farris, A. B., Singh, K., Leopardi, F., Hamby, K., Sen, S., Polnett, A., Deane, T., Song, M., Stempora, L., Strobert, E., Kirk, A. D., Larsen, C. P., Kean, L. S.

“…Although there is evidence linking hematopoietic chimerism induction and solid organ transplant tolerance, the mechanistic requirements for chimerism‐induced…”
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NK Cells Rapidly Reject Allogeneic Bone Marrow in the Spleen Through a Perforin‐ and Ly49D‐Dependent, but NKG2D‐Independent Mechanism by Hamby, K., Trexler, A., Pearson, T. C., Larsen, C. P., Rigby, M. R., Kean, L. S.

“…We have used a sensitive and specific in vivo killing assay to monitor the kinetics, anatomic location and mechanisms controlling NK‐mediated rejection of…”
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Human and Porcine Islet Transplants in a New Double Capsule by Safley, S.A, Gordon, K.B, Barber, G.F, Holdcraft, R.W, Turgeon, N, Larsen, C.P, Gazda, L, Weber, C.J

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Expanded Nonhuman Primate Tregs Exhibit a Unique Gene Expression Signature and Potently Downregulate Alloimmune Responses by Anderson, A., Martens, C. L., Hendrix, R., Stempora, L. L., Miller, W. P., Hamby, K., Russell, M., Strobert, E., Blazar, B. R., Pearson, T. C., Larsen, C. P., Kean, L. S.

“…We have established two complementary strategies for purifying naturally occurring regulatory T cells (Tregs) from rhesus macaques in quantities that would be…”
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Completion of the first FDA phase 3 multicenter trial of Islet transplantation in type 1 diabetes by the NIH CIT consortium by Ricordi, C, Hering, B, Bridges, N, Eggerman, T, Naji, A, Posselt, A, Stock, P, Kaufman, D, Larsen, C.P, Turgeon, N, Oberholzer, J, Barbaro, B, Korsgren, O, Markmann, J, Alejandro, R, Rickels, M.R, Senior, P.A, Luo, X, Zhang, X, Bellin, M, Lei, J, Clarke, W, Hunsicker, L, Goldstein, J, Czarniecki, C, Priore, A, Green, N, Shapiro, A

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150: Flow Cytometric Parameters of CD8 Lavage Cells in Detection of Acute Cellular Rejection in Lung Transplant by Neujahr, D.C, Mohammed, A, Ulukpo, O, Pelaez, A, Ramirez, A, Lawrence, E.C, Force, S.D, Gal, A.A, Larsen, C.P, Kirk, A.D

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455: Surgical Repair of Gastroesophageal Reflux in Lung Transplant Recipients Is Associated with Decreased Armed Effector T Cells and Increased Exhausted T Cells within the Allograft by Neujahr, D.C, Pelaez, A, Ramirez, A, Force, S.D, Lawrence, E.C, Cardona, A.C, Kirk, A.D, Larsen, C.P

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