Search Results - "Larschan, Erica N."
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Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types
Published in Genome Biology (03-06-2016)“…For many genes, RNA polymerase II stably pauses before transitioning to productive elongation. Although polymerase II pausing has been shown to be a mechanism…”
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The Drosophila CLAMP protein associates with diverse proteins on chromatin
Published in PloS one (27-12-2017)“…Gaining new insights into gene regulation involves an in-depth understanding of protein-protein interactions on chromatin. A powerful model for studying…”
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Dosage Compensation: How to Be Compensated…Or Not?
Published in Current biology (02-12-2019)“…Diverse dosage compensation mechanisms have evolved across species to equalize gene expression between sexes and between the sex chromosomes and autosomes. New…”
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The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males
Published in Development (Cambridge) (23-08-2019)“…The binding of the male-specific lethal dosage compensation complex (DCC) exclusively to the male X chromosome provides an excellent model system to understand…”
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Wisdom from the fly
Published in Trends in genetics (01-11-2014)“…Arguably, almost all research in Drosophila can be considered basic research, yet many of the most essential and fundamental concepts of human genetics were…”
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Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP
Published in Genes & development (15-07-2017)“…The conserved histone locus body (HLB) assembles prior to zygotic gene activation early during development and concentrates factors into a nuclear domain of…”
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The essential Drosophila CLAMP protein differentially regulates non-coding roX RNAs in male and females
Published in Chromosome research (01-06-2017)“…Heterogametic species require chromosome-wide gene regulation to compensate for differences in sex chromosome gene dosage. In Drosophila melanogaster ,…”
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Comparative analysis of metazoan chromatin organization
Published in Nature (London) (28-08-2014)“…A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human are analysed;…”
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CLAMP and Zelda function together to promote Drosophila zygotic genome activation
Published in eLife (03-08-2021)“…During the essential and conserved process of zygotic genome activation (ZGA), chromatin accessibility must increase to promote transcription. Drosophila is a…”
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