Search Results - "Larrouture, Quitterie C."

Support of bone mineral deposition by regulation of pH by Blair, Harry C, Larrouture, Quitterie C, Tourkova, Irina L, Liu, Li, Bian, Jing Hao, Stolz, Donna Beer, Nelson, Deborah J, Schlesinger, Paul H

“…Osteoblasts secrete collagen and isolate bone matrix from extracellular space. In the matrix, alkaline phosphatase generates phosphate that combines with…”
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Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs by Larrouture, Quitterie C., Cribbs, Adam P., Rao, Srinivasa R., Philpott, Martin, Snelling, Sarah J., Knowles, Helen J.

“…Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative…”
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The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1 by Robinson, Lisa J, Soboloff, Jonathan, Tourkova, Irina L, Larrouture, Quitterie C, Onwuka, Kelechi M, Papachristou, Dionysios J, Gross, Scott, Hooper, Robert, Samakai, Elsie, Worley, Paul F, Liu, Peng, Tuckermann, Jan, Witt, Michelle R, Blair, Harry C

“…The calcium-selective ion channel Orai1 has a complex role in bone homeostasis, with defects in both bone production and resorption detected in Orai1 germline…”
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Creatine energy substrate increases bone density in the Pahenu2 classical PKU mouse in the context of phenylalanine restriction by Dobrowolski, Steven F., Tourkova, Irina L., Larrouture, Quitterie C., Blair, Harry C.

“…Pathophysiology of osteopenia in phenylalanine hydroxylase (PAH) deficient phenylketonuria (PKU) is poorly characterized. The Pahenu2 mouse is universally…”
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Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice by Tourkova, Irina L., Larrouture, Quitterie C., Liu, Silvia, Luo, Jianhua, Shipman, Katherine E., Onwuka, Kelechi M., Weisz, Ora A., Riazanski, Vladimir, Nelson, Deborah J., MacDonald, Matthew L., Schlesinger, Paul H., Blair, Harry C.

“…Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na+/H+ exchange, but apical proton uptake is…”
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Glutamine energy substrate anaplerosis increases bone density in the Pahenu2 classical PKU mouse in the absence of phenylalanine restriction by Dobrowolski, Steven F., Phua, Yu Leng, Tourkova, Irina L., Sudano, Cayla, Vockley, Jerry, Larrouture, Quitterie C., Blair, Harry C.

“…Osteopenia is an under‐investigated clinical presentation of phenylalanine hydroxylase (PAH)‐deficient phenylketonuria (PKU). While osteopenia is not fully…”
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The ecto-nucleotide pyrophosphatase/phosphodiesterase 2 promotes early osteoblast differentiation and mineralization in stromal stem cells by Tourkova, Irina L, Larrouture, Quitterie C, Liu, Silvia, Luo, Jianhua, Schlesinger, Paul H, Blair, Harry C

“…The phosphodiesterase enzymes mediate calcium-phosphate deposition in various tissues, although which enzymes are active in bone mineralization is unclear…”
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Age-related decline in bone mineral transport and bone matrix proteins in osteoblasts from stromal stem cells by Tourkova, Irina L, Larrouture, Quitterie C, Onwuka, Kelechi M, Liu, Silvia, Luo, Jianhua, Schlesinger, Paul H, Blair, Harry C

“…We studied osteoblast bone mineral transport and matrix proteins as a function of age. In isolated bone marrow cells from long bones of young (3 or 4 mo) and…”
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Epithelial‐like transport of mineral distinguishes bone formation from other connective tissues by Blair, Harry C., Larrouture, Quitterie C., Tourkova, Irina L., Nelson, Deborah J., Dobrowolski, Steven F., Schlesinger, Paul H.

“…We review unique properties of bone formation including current understanding of mechanisms of bone mineral transport. We focus on formation only; mechanism of…”
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Adrenocorticotropic hormone and 1,25-dihydroxyvitamin D 3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes by Tourkova, Irina L, Liu, Li, Sutjarit, Nareerat, Larrouture, Quitterie C, Luo, Jianhua, Robinson, Lisa J, Blair, Harry C

“…To improve definition of the physical and hormonal support of bone formation, we studied differentiation of human osteoblasts in vitro at varying combinations…”
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Phylogeny and chemistry of biological mineral transport by Schlesinger, Paul H., Braddock, Demetrios T., Larrouture, Quitterie C., Ray, Evan C., Riazanski, Vladimir, Nelson, Deborah J., Tourkova, Irina L., Blair, Harry C.

“…Three physiologically mineralizing tissues — teeth, cartilage and bone — have critical common elements and important evolutionary relationships…”
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Growth and mineralization of osteoblasts from mesenchymal stem cells on microporous membranes: Epithelial-like growth with transmembrane resistance and pH gradient by Larrouture, Quitterie C., Tourkova, Irina L., Stolz, Donna B., Riazanski, Vladimir, Onwuka, Kelechi M., Franks, Jonathan M., Dobrowolski, Steven F., Nelson, Deborah J., Schlesinger, Paul H., Blair, Harry C.

“…Osteoblasts in vivo form an epithelial-like layer with tight junctions between cells. Bone formation involves mineral transport into the matrix and acid…”
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The function of the calcium channel Orai1 in osteoclast development by Robinson, Lisa J., Soboloff, Jonathan, Tourkova, Irina L., Larrouture, Quitterie C., Witt, Michelle R., Gross, Scott, Hooper, Robert, Samakai, Elsie, Worley, Paul F., Barnett, John B., Blair, Harry C.

“…To determine the intrinsic role of Orai1 in osteoclast development, Orai1‐floxed mice were bred with LysMcre mice to delete Orai1 from the myeloid lineage…”
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A New View of Bone Loss in Phenylketonuria by Dobrowolski, Steven F., Tourkova, Irina L., Sudano, Cayla R., Larrouture, Quitterie C, Blair, Harry C.

“…Osteopenia is common in phenylalanine hydroxylase deficient phenylketonuria (PKU). PKU is managed by limiting dietary phenylalanine. Osteopenia in PKU might…”
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Adrenocorticotropic hormone and 1,25-dihydroxyvitamin D3 enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes by Tourkova, Irina L, Liu, Li, Sutjarit, Nareerat, Larrouture, Quitterie C, Luo, Jianhua, Robinson, Lisa J, Blair, Harry C

“…To improve definition of the physical and hormonal support of bone formation, we studied differentiation of human osteoblasts in vitro at varying combinations…”
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Glutamine energy substrate anaplerosis increases bone density in the Pah enu2 classical PKU mouse in the absence of phenylalanine restriction by Dobrowolski, Steven F, Phua, Yu Leng, Tourkova, Irina L, Sudano, Cayla, Vockley, Jerry, Larrouture, Quitterie C, Blair, Harry C

“…Osteopenia is an under-investigated clinical presentation of phenylalanine hydroxylase (PAH)-deficient phenylketonuria (PKU). While osteopenia is not fully…”
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Chloride–hydrogen antiporters ClC‐3 and ClC‐5 drive osteoblast mineralization and regulate fine‐structure bone patterning in vitro by Larrouture, Quitterie C., Nelson, Deborah J., Robinson, Lisa J., Liu, Li, Tourkova, Irina, Schlesinger, Paul H., Blair, Harry C.

“…Osteoblasts form an epithelium‐like layer with tight junctions separating bone matrix from extracellular fluid. During mineral deposition, calcium and…”
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Suppression of arthritis-induced bone erosion by a CRAC channel antagonist by Blair, Harry C, Soboloff, Jonathan, Robinson, Lisa J, Tourkova, Irina L, Larrouture, Quitterie C, Witt, Michelle R, Holaskova, Ida, Schafer, Rosana, Elliott, Meenal, Hirsch, Raphael, Barnett, John B

“…ObjectiveWe have shown in vitro and in vivo that osteoclast maturation requires calcium-release activated calcium (CRAC) channels. In inflammatory arthritis,…”
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Osteoclasts Are Multinucleated Cells that Degrade Cartilage as Well as Bone by Larrouture, Quitterie C

“…Osteoclasts are essential for bone remodelling and are normally found at the bone surface where they create resorption pits. Osteoclasts are present in…”
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