Search Results - "Larraufie, Marie‐Hélène"

Visible-Light-Induced Photoreductive Generation of Radicals from Epoxides and Aziridines by Larraufie, Marie-Hélène, Pellet, Rémy, Fensterbank, Louis, Goddard, Jean-Philippe, Lacôte, Emmanuel, Malacria, Max, Ollivier, Cyril

“…It's a trap! Both epoxides and aziridines substituted by an aryl ketone can be reduced efficiently using visible‐light photoredox catalysts. The radicals…”
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Radical Migration of Substituents of Aryl Groups on Quinazolinones Derived from N-Acyl Cyanamides by Larraufie, Marie-Hélène, Courillon, Christine, Ollivier, Cyril, Lacôte, Emmanuel, Malacria, Max, Fensterbank, Louis

“…A newly designed radical cascade involving N-acyl cyanamides is reported. It builds on aromatic homolytic substitutions as intermediate events and leads to…”
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Expeditious Synthesis of Phenanthridines from Benzylamines via Dual Palladium Catalysis by Maestri, Giovanni, Larraufie, Marie-Hélène, Derat, Étienne, Ollivier, Cyril, Fensterbank, Louis, Lacôte, Emmanuel, Malacria, Max

“…A method for the synthesis of phenanthridines from benzylamines and aryl iodides which uses a dual palladium-catalyzed process is developed. The domino…”
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Radical Synthesis of Guanidines from N-Acyl Cyanamides by Larraufie, Marie-Hélène, Ollivier, Cyril, Fensterbank, Louis, Malacria, Max, Lacôte, Emmanuel

“…Center stage: Additions of nitrogen‐centered radicals to cyanamide compounds provided the first radical synthesis of aromatic polycyclic guanidine derivatives…”
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A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress by Thams, Sebastian, Lowry, Emily Rhodes, Larraufie, Marie-Hélène, Spiller, Krista J., Li, Hai, Williams, Damian J., Hoang, Phuong, Jiang, Elise, Williams, Luis A., Sandoe, Jackson, Eggan, Kevin, Lieberam, Ivo, Kanning, Kevin C., Stockwell, Brent R., Henderson, Christopher E., Wichterle, Hynek

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease selectively targeting motor neurons in the brain and spinal cord. The reasons for…”
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Exception to the ortho Effect in Palladium/Norbornene Catalysis by Larraufie, Marie-Hélène, Maestri, Giovanni, Beaume, Aurore, Derat, Étienne, Ollivier, Cyril, Fensterbank, Louis, Courillon, Christine, Lacôte, Emmanuel, Catellani, Marta, Malacria, Max

“…Out of the norm: The first deviation from the ortho effect in palladium/norbornene catalysis, as evidenced by the resulting products, is reported (see scheme)…”
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Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele by Zhang, Yan, Larraufie, Marie-Hélène, Musavi, Leila, Akkiraju, Hemanth, Brown, Lewis M, Stockwell, Brent R

“…RAS mutations are found in 30% of all human cancers, with KRAS the most frequently mutated among the three RAS isoforms (KRAS, NRAS, and HRAS). However,…”
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Rearrangements of N‑Acyl Isothioureas. Alternate Access to Acylguanidines from Cyanamides by Maestri, Giovanni, Larraufie, Marie-Hélène, Ollivier, Cyril, Malacria, Max, Fensterbank, Louis, Lacôte, Emmanuel

“…We report a tin-free one-pot radical approach to the synthesis of N-acyl isothioureas and acylguanidines from N-acyl cyanamides. Photoactivated reduction of…”
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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury by Larraufie, Marie-Hélène, Gao, Xiaolin, Xia, Xiaobo, Devine, Patrick J, Kallen, Joerg, Liu, Dong, Michaud, Gregory, Harsch, Andreas, Savage, Nik, Ding, Jian, Tan, Kian, Mihalic, Manuel, Roggo, Silvio, Canham, Stephen M, Bushell, Simon M, Krastel, Philipp, Gao, Jinhai, Izaac, Aude, Altinoglu, Erhan, Lustenberger, Philipp, Salcius, Michael, Harbinski, Fred, Williams, Eric T, Zeng, Liling, Loureiro, Joseph, Cong, Feng, Fryer, Christy J, Klickstein, Lloyd, Tallarico, John A, Jain, Rishi K, Rothman, Deborah M, Wang, Shaowen

“…Acute kidney injury (AKI) is a life-threatening disease with no known curative or preventive therapies. Data from multiple animal models and human studies have…”
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Synthesis of natural quinazolinones and some of their analogues through radical cascade reactions involving N-acylcyanamides by Larraufie, Marie-Hélène, Malacria, Max, Courillon, Christine, Ollivier, Cyril, Fensterbank, Louis, Lacôte, Emmanuel

“…Two natural quinazolinones and two analogues can be prepared from the cascade cyclizations of alkyl-substituted N-acylcyanamide radicals, including 5-exo-dig…”
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Intramolecular Homolytic Substitution of Sulfinates and Sulfinamides by Coulomb, Julien, Certal, Victor, Larraufie, Marie‐Hélène, Ollivier, Cyril, Corbet, Jean‐Pierre, Mignani, Gérard, Fensterbank, Louis, Lacôte, Emmanuel, Malacria, Max

“…A general and efficient method for the synthesis of cyclic sulfinates and sulfinamides based on intramolecular homolytic substitution (SHi) at the sulfur atom…”
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Visible-Light-Induced Photoreductive Generation of Radicals from Epoxides and Aziridines by Larraufie, Marie-Hélène, Pellet, Rémy, Fensterbank, Louis, Goddard, Jean-Philippe, Lacôte, Emmanuel, Malacria, Max, Ollivier, Cyril

“…Gefangen! Epoxide und Aziridine mit Arylketonsubstituent können effizient mit Photoredoxkatalysatoren reduziert werden, die mit sichtbarem Licht arbeiten. Die…”
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Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility by Larraufie, Marie-Helene, Yang, Wan Seok, Jiang, Elise, Thomas, Ajit G., Slusher, Barbara S., Stockwell, Brent R.

“…[Display omitted] Introducing a reactive carbonyl to a scaffold that does not otherwise have an electrophilic functionality to create a reversible covalent…”
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Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa by Jover, Irene, Ramos, Maria C., Escámez, María José, Lozoya, Estrella, Tormo, José R., de Prado-Verdún, Diana, Mencía, Ángeles, Pont, Mercè, Puig, Carles, Larraufie, Marie-Helene, Gutiérrez-Caballero, Cristina, Reyes, Fernando, Trincado, Juan Luis, García-González, Vicente, Cerrato, Rosario, Andrés, Miriam, Crespo, Maribel, Vicente, Francisca, Godessart, Nuria, Genilloud, Olga, Larcher, Fernando, Nueda, Arsenio

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease caused by loss of function mutations in the gene coding for collagen VII (C7) due…”
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Radical Synthesis of Guanidines from N-Acyl Cyanamides by Larraufie, Marie-Hélène, Ollivier, Cyril, Fensterbank, Louis, Malacria, Max, Lacôte, Emmanuel

“…Auf dem Podium: Das Einführen von stickstoffzentrierten Radikalen in Cyanamidverbindungen ermöglichte die erste radikalische Synthese aromatischer…”
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Exception to the ortho Effect in Palladium/Norbornene Catalysis by Larraufie, Marie-Hélène, Maestri, Giovanni, Beaume, Aurore, Derat, Étienne, Ollivier, Cyril, Fensterbank, Louis, Courillon, Christine, Lacôte, Emmanuel, Catellani, Marta, Malacria, Max

“…Die erste Abweichung vom ortho‐Effekt in der Palladium‐Norbornen‐Katalyse gibt sich anhand der Reaktionsprodukte zu erkennen (siehe Schema). DFT‐Rechnungen…”
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Radical Synthesis of Guanidines from N ‐Acyl Cyanamides by Larraufie, Marie‐Hélène, Ollivier, Cyril, Fensterbank, Louis, Malacria, Max, Lacôte, Emmanuel

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Exception to the ortho Effect in Palladium/Norbornene Catalysis by Larraufie, Marie‐Hélène, Maestri, Giovanni, Beaume, Aurore, Derat, Étienne, Ollivier, Cyril, Fensterbank, Louis, Courillon, Christine, Lacôte, Emmanuel, Catellani, Marta, Malacria, Max

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Visible‐Light‐Induced Photoreductive Generation of Radicals from Epoxides and Aziridines by Larraufie, Marie‐Hélène, Pellet, Rémy, Fensterbank, Louis, Goddard, Jean‐Philippe, Lacôte, Emmanuel, Malacria, Max, Ollivier, Cyril

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