Search Results - "Laroux, Stephen"

A Comparative Evaluation of the Measurement Properties of Three Histological Indices of Mucosal Healing in Ulcerative Colitis: Geboes Score, Robarts Histopathology Index and Nancy Index by Peyrin-Biroulet, Laurent, Arenson, Ethan, Rubin, David T, Siegel, Corey A, Lee, Scott, Stephen Laroux, F, Zhou, Wen, Finney-Hayward, Tricia, Sanchez Gonzalez, Yuri, Shields, Alan L

“…Abstract Background and Aims To inform their future use in regulated clinical trials to evaluate treatment efficacy hypotheses, the measurement properties of…”
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Cutting Edge: MyD88 Controls Phagocyte NADPH Oxidase Function and Killing of Gram-Negative Bacteria by Laroux, F. Stephen, Romero, Xavier, Wetzler, Lee, Engel, Pablo, Terhorst, Cox

“…MyD88 is an adaptor protein for the TLR family of proteins that has been implicated as a critical mediator of innate immune responses to pathogen detection. In…”
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Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models by Zhang, Liang, Wallace, Craig D., Erickson, Jamie E., Nelson, Christine M., Gaudette, Stephanie M., Pohl, Calvin S., Karsen, Samuel D., Simler, Gricelda H., Peng, Ruoqi, Stedman, Christopher A., Laroux, F. Stephen, Wurbel, Marc A., Kamath, Rajesh V., McRae, Bradford L., Schwartz Sterman, Annette J., Mitra, Soumya

“…Intestinal permeability and neutrophil activity are closely linked to inflammatory bowel disease (IBD) pathophysiology. Here we discuss two techniques for…”
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Role of the Proteasome and NF-κ B in Streptococcal Cell Wall-Induced Polyarthritis by Palombella, Vito J., Conner, Elaine M., Fuseler, John W., Destree, Antonia, Davis, Jonathan M., Laroux, F. Stephen, Wolf, Robert E., Huang, Jianqing, Brand, Stephen, Elliott, Peter J., Lazarus, Douglas, McCormack, Teresa, Parent, Lana, Stein, Ross, Adams, Julian, Grisham, Matthew B.

“…The transcription factor NF-κ B activates a number of genes whose protein products are proinflammatory. In quiescent cells, NF-κ B exists in a latent form and…”
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Mechanisms of inflammation: the good, the bad and the ugly by Laroux, F Stephen

“…To the general public, the term, inflammation, is associated with pain, swelling, fever and a general sense of unease ranging from mere nuisance to…”
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Role of T-cell-associated lymphocyte function-associated antigen-1 in the pathogenesis of experimental colitis by Pavlick, Kevin P., Ostanin, Dmitry V., Furr, Kathryn L., Laroux, F. Stephen, Brown, Carla M., Gray, Laura, Kevil, Christopher G., Grisham, Matthew B.

“…The β2 integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) is important for lymphocyte trafficking and activation as well as recruitment to…”
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Correlation of mucosal healing endpoints with long-term clinical and patient-reported outcomes in ulcerative colitis by Parkes, Gareth, Ungaro, Ryan C., Danese, Silvio, Abreu, Maria T., Arenson, Ethan, Zhou, Wen, Ilo, Dapo, Laroux, F. Stephen, Deng, Huiwen, Sanchez Gonzalez, Yuri, Peyrin-Biroulet, Laurent

“…Background We evaluated the clinical relevance of achieving histologic endoscopic mucosal improvement (HEMI) and the more stringent target of histologic…”
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Efficacy and Safety of Upadacitinib for Perianal Fistulizing Crohn’s Disease: A Post Hoc Analysis of 3 Phase 3 Trials by Colombel, Jean-Frédéric, Lacerda, Ana P., Irving, Peter M., Panaccione, Remo, Reinisch, Walter, Rieder, Florian, Steinlauf, Adam, Schwartz, David, Feng, Tian, Dubcenco, Elena, Anyanwu, Samuel I., Laroux, F. Stephen, Cunneen, Colla, Powell, Nick

“…Efficacy of upadacitinib, an oral Janus kinase inhibitor, for moderate-to-severe Crohn’s disease was demonstrated in phase 3 induction (U-EXCEL, U-EXCEED) and…”
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Myocardial Ischemia/Reperfusion Injury in NADPH Oxidase–Deficient Mice by Hoffmeyer, Michaela R, Jones, Steven P, Ross, Christopher R, Sharp, Brent, Grisham, Matthew B, Laroux, F Stephen, Stalker, Timothy J, Scalia, Rosario, Lefer, David J

“…ABSTRACT—Previous studies have suggested that oxygen-derived free radicals are involved in the pathophysiology of myocardial ischemia/reperfusion (MI/R)…”
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DSS‐induced colitis is exacerbated in STAT‐6 knockout mice by Elrod, John W, Laroux, F Stephen, Houghton, Jeffrey, Carpenter, April, Ando, Tomoaki, Jennings, Merilyn H, Grisham, Matt, Walker, Nicole, Alexander, J Steven

“…Background: Several transcription factors have been proposed to regulate IBD including the signal transducer and activator of transcription‐6 (STAT‐6)…”
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Cedirogant Population Pharmacokinetics and Pharmacodynamic Analyses of Interleukin‐17A Inhibition in Two Phase 1 Studies in Healthy Participants and Participants with Moderate to Severe Psoriasis by Maier, Corinna S., Eckert, Doerthe, Laroux, F. Stephen, Hew, Kinjal M., Suleiman, Ahmed A., Liu, Wei, Mohamed, Mohamed‐Eslam F.

“…Cedirogant (ABBV‐157) is an orally bioavailable inverse agonist of retinoic acid‐related orphan receptor gamma thymus. Data from 2 Phase 1 studies were used to…”
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Regulation of chronic colitis in athymic nu/nu (nude) mice by Laroux, F. Stephen, Norris, Hillary H., Houghton, Jeff, Pavlick, Kevin P., Bharwani, Sulaiman, Merrill, Dana M., Fuseler, John, Chervenak, Robert, Grisham, Matthew B.

“…The objective of this study was to assess the roles of NK cells, B cells and/or intraepithelial lymphocytes (IEL) in suppressing the development of colitis in…”
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Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease by Pavlick, Kevin P, Laroux, F Stephen, Fuseler, John, Wolf, Robert E, Gray, Laura, Hoffman, Jason, Grisham, Matthew B

“…The inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis) are a collection of chronic idiopathic inflammatory disorders of the intestine…”
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The Oxidative and Nitrosative Chemistry of the Nitric Oxide/Superoxide Reaction in the Presence of Bicarbonate by Jourd'heuil, David, Miranda, Katrina M., Kim, Sung M., Espey, Michael G., Vodovotz, Yoram, Laroux, Stephen, Mai, Christie T., Miles, Allen M., Grisham, Matthew B., Wink, David A.

“…The primary product of the interaction between nitric oxide (NO) and superoxide ([figure]) is peroxynitrite (ONOO−), which is capable of either oxidizing or…”
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43131 Population Pharmacokinetic and Pharmacodynamic Analyses of Cedirogant in Healthy Subjects and Subjects with Moderate to Severe Psoriasis by Maier, Corinna, Eckert, Doerthe, Laroux, Stephen, Hew, Kinjal M., Suleiman, Ahmed, Liu, Wei, Mohamed, Mohamed-Eslam F.

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Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression by Ji, Hong-bin, Liao, Gongxian, Faubion, William A, Abadia-Molina, Ana C, Cozzo, Cristina, Laroux, F. Stephen, Caton, Andrew, Terhorst, Cox

“…CD4(+)25(+) regulatory T (Treg) cells maintain immunological self-tolerance through mechanisms that are only in part understood. Previous studies suggest that…”
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Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis by Krieglstein, Christian F., Cerwinka, Wolfgang H., Sprague, Andrew G., Laroux, F. Stephen, Grisham, Matthew B., Koteliansky, Victor E., Senninger, Norbert, Granger, D. Neil, de Fougerolles, Antonin R.

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Targeting dendritic cell inhibitory receptors to down regulate immune response in inflammatory disease by Wei, Hsi-Ju, Chen, Liang, Patil, Suresh, Barbon, Jeffrey, Waire, James, McCarthy, Donna, Deora, Arun, Laroux, Stephen, Jin, Liang, Tian, Yu, Veldman, Trudi, Ghayur, Tariq, Hegde, Subramanya

“…Abstract Immune regulator receptors play a crucial role in immune homeostasis by balancing activating vs inhibitory immune responses and are distributed across…”
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Use of MM-SES-CD Endoscopic Improvement Thresholds Enhances Effect Size Differentiation between Adalimumab vs. Placebo: A Post-hoc Analysis of the EXTEND Trial by Wong, Emily C L, Dulai, Parambir S, Marshall, John K, Laroux, Stephen, Jairath, Vipul, Reinisch, Walter, Narula, Neeraj

“…Abstract Introduction The Modified Multiplier of the SES-CD (MM-SES-CD) refines the assessment of endoscopic Crohn's Disease (CD) severity by differentially…”
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1095 EXHALED BREATH ANALYSIS OF VOLATILE ORGANIC COMPOUNDS IS ASSOCIATED WITH LUMINAL DISEASE ACTIVITY IN PATIENTS WITH ULCERATIVE COLITIS by Qazi, Taha, Bhat, Shubha, Ma, Jin, Wong, Katrina, Rayan, Carla, Gramuglia, Mary Beth, Grove, David, Laroux, Stephen, Regueiro, Miguel D., Cohen, Benjamin L., Zambrano, Javier A., Dweik, Raed, Rieder, Florian

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