Search Results - "Larocque, James"

Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia by Ogana, Heather A, Hurwitz, Samantha, Hsieh, Chih-Lin, Geng, Huimin, Müschen, Markus, Bhojwani, Deepa, Wolf, Mark A, Larocque, James, Lieber, Michael R, Kim, Yong Mi

“…As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed…”
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Analysis of ubiquitin E3 ligase activity using selective polyubiquitin binding proteins by Marblestone, Jeffrey G., LaRocque, James P., Mattern, Michael R., Leach, Craig A.

“…The ubiquitin proteasome pathway controls the cellular degradation of ~80–90% of the proteome in a highly regulated manner. In this pathway, E3 ligases are…”
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Ion channel screening by Dunlop, John, Bowlby, Mark, Peri, Ravikumar, Tawa, Gregory, LaRocque, James, Soloveva, Veronica, Morin, John

“…Ion channels are attractive targets for drug discovery with recent estimates indicating that voltage and ligand-gated channels account for the third and fourth…”
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High-throughput screening for Kv1.3 channel blockers using an improved FLIPR-based membrane-potential assay by Liu, Kun, Samuel, Manoj, Tillett, Jeff, Hennan, James K, Mekonnen, Belew, Soloveva, Veronica, Harrison, Richard K, Paslay, Jeff W, Larocque, James

“…Voltage-gated K(+) channels are potential drug targets for an increasing number of disease indications. Searching for compounds that modulate K(+) channel…”
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Orbital MALT Lymphoma in a Patient with Graves' Ophthalmopathy: A Unique Observation by Stark, James J., Newsom, Roger W., Roman, Janice, LaRocque, James C., Richardson, Donald W.

“…A 57-year-old woman with a six-year history of Graves' Disease with ophthalmopathy developed unilateral periorbital swelling. CT scan suggested a lacrimal…”
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Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene by van Zeijl, M, Fairhurst, J, Jones, T R, Vernon, S K, Morin, J, LaRocque, J, Feld, B, O'Hara, B, Bloom, J D, Johann, S V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin by Plotch, S J, O'Hara, B, Morin, J, Palant, O, LaRocque, J, Bloom, J D, Lang, Jr, S A, DiGrandi, M J, Bradley, M, Nilakantan, R, Gluzman, Y

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Role of Gender in Violence Experienced by Adults With Developmental Disabilities by Platt, Laura, Powers, Laurie, Leotti, Sandra, Hughes, Rosemary B., Robinson-Whelen, Susan, Osburn, Sherri, Ashkenazy, Elesia, Beers, Leanne, Lund, Emily M., Nicolaidis, Christina, Hughes, Rosemary B., Powers, Laurie E., Nicolaidis, Christina, Katz, Marsha, Oschwald, Mary, Larson, Darren, Plourde, Eddie, Raymaker, Dora, Howard, Lisa, Ashkenazy, Elesia, Beers, Leanne, Boatman, Mark, Gardner, Gail Bernice, Gray, Nicole, Grantham, Leah, Larocque, James, Millin, Mary, Osburn, Sherri, Salomon, Janice, Star, Albert, Tedlow, Andrew, Wallington, Annie, Curry, Mary Ann, Robinson-Whelen, Susan, Allen, Patti, Goe, Rebecca, Leotti, Sandy, Lund, Emily M.

“…Violence against people with developmental disabilities is a highly prevalent yet understudied phenomenon. In particular, there is a paucity of literature…”
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Cancer Immunotherapy via Regulation of the Ubiquitin Proteasome Pathway by Kumar, Suresh, Wu, Jian, LaRocque, James, Agarwal, Saket, Marblestone, Jeffrey, Kodrasov, Matthew, Weinstock, Joseph, Mattern, Michael

“…Abstract only Immune evasion is a hallmark feature of tumors as they employ various strategies to suppress the immune system's ability to recognize and destroy…”
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The relation of abuse to physical and psychological health in adults with developmental disabilities by Hughes, Rosemary B, Robinson-Whelen, Susan, Raymaker, Dora, Lund, Emily M, Oschwald, Mary, Katz, Marsha, Starr, Albert, Ashkenazy, Elesia, Powers, Laurie E, Nicolaidis, Christina

“…People with developmental disabilities are at disproportionately high risk of abuse. Although considerable evidence exists on the health-related consequences…”
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Abstract 5433: Discovery and development of novel USP2 inhibitors for cancer therapy by Kumar, Suresh, LaRocque, James P., Marblestone, Jeffrey G., Wu, Jian, Weinstock, Joseph, Sterner, David E., Mattern, Michael R.

“…Ubiquitylation and deubiquitylation control the stability, localization and activity of many cellular proteins. Deubiquitylation is performed by a family of…”
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Ubiquitin ligase Idol Inhibitors for Treating Hypercholesterolemia by Marblestone, Jeffrey, Wu, Jian, LaRocque, James, Agarwal, Saket, Kodrasov, Matthew, Weinstock, Joseph, Kumar, Suresh, Mattern, Michael, Sterner, David

“…Abstract only Despite widespread use of statins and other therapeutics, hypercholesterolemia remains a significant medical issue for a many patients unable to…”
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Abstract A21: Inhibition of USP7 for the treatment of multiple myeloma and other malignancies by Nicholson, Benjamin, Kodrasov, Matthew P., LaRocque, James P., Eddins, Michael J., Kumar, Suresh, Chauhan, Dharminder, Anderson, Kenneth C., Mattern, Michael R.

“…The conjugation and deconjugation of ubiquitin controls the stability, localization and activity of many cellular proteins. Deconjugation of ubiquitin is…”
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Abstract 5432: Discovery and characterization of USP22 inhibitors as novel anti-cancer agents by Wang, Feng, Stanek, Timothy R., Biswas, Leelabati, Kodrasov, Matthew, LaRocque, James, Wu, Jian, Sterner, David, Weinstock, Joseph, Mattern, Michael, McMahon, Steven B., Kumar, Suresh

“…The degradation of most cellular proteins is regulated by coordinated addition and removal of ubiquitin by families of ubiquitin E3 ligases and…”
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Community-Based Participatory Research to Adapt Health Measures for Use by People With Developmental Disabilities by Nicolaidis, Christina, Raymaker, Dora, Katz, Marsha, Oschwald, Mary, Goe, Rebecca, Leotti, Sandra, Grantham, Leah, Plourde, Eddie, Salomon, Janice, Hughes, Rosemary B, Powers, Laurie E

“…People with developmental disabilities (DD) are often not included as participants in research owing to a variety of ethical and practical challenges. One…”
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Characterization of the cloned full-length and a truncated human target of rapamycin: Activity, specificity, and enzyme inhibition as studied by a high capacity assay by Toral-Barza, Lourdes, Zhang, Wei-Guo, Lamison, Craig, LaRocque, James, Gibbons, James, Yu, Ker

“…The mammalian target of rapamycin (mTOR/TOR) is implicated in cancer and other human disorders and thus an important target for therapeutic intervention. To…”
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Development and comparison of two nonradioactive kinase assays for I kappa B kinase by Sadler, Tammy M, Achilleos, Maria, Ragunathan, Shoba, Pitkin, Adam, LaRocque, James, Morin, John, Annable, Rebecca, Greenberger, Lee M, Frost, Philip, Zhang, Yixian

“…In response to diverse stimuli, the transcription factor NF-κB is activated by the IKK kinase complex containing two kinases (IKKα and IKKβ) that phosphorylate…”
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Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide) by Dunlop, John, Lock, Tim, Jow, Brian, Sitzia, Fabrizio, Grauer, Steven, Jow, Flora, Kramer, Angela, Bowlby, Mark R, Randall, Andrew, Kowal, Dianne, Gilbert, Adam, Comery, Thomas A, Larocque, James, Soloveva, Veronica, Brown, Jon, Roncarati, Renza

“…The alpha7 nicotinic acetylcholine receptor (nAChR) has been implicated in Alzheimer's disease and schizophrenia, leading to efforts targeted toward…”
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Glucocerebrosidase treatment of type I Gaucher disease with severe pulmonary involvement by PELINI, M, BOICE, D, O'NEIL, K, LAROCQUE, J

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When Robots Are Good: Fully Automated Thermo LAS Robotic Assay System with Dual FLIPRTETRA and TAP SelecT Robotic Cell Culture System by Soloveva, Veronica, Larocque, James, Mckillip, Edward

“…Cell-based assays for identification of biologically active small molecules from chemical libraries are becoming increasingly popular for HTS aimed at a…”
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