Search Results - "Larochelle, N"

Muscle-Specific Overexpression of the Adenovirus Primary Receptor CAR Overcomes Low Efficiency of Gene Transfer to Mature Skeletal Muscle by Nalbantoglu, J, Larochelle, N, Wolf, E, Karpati, G, Lochmuller, H, Holland, P C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice by Lochmüller, H, Petrof, B J, Pari, G, Larochelle, N, Dodelet, V, Wang, Q, Allen, C, Prescott, S, Massie, B, Nalbantoglu, J, Karpati, G

“…Adenovirus (AV)-mediated gene transfer into skeletal muscles of adult immune-competent animals has been limited by the fact that a cell-mediated immune attack…”
Get more information

Efficient muscle-specific transgene expression after adenovirus-mediated gene transfer in mice using a 1.35 kb muscle creatine kinase promoter/enhancer by LAROCHELLE, N, LOCHMÜLLER, H, NALBANTOGLU, J, ZHAO, J, JANI, A, HALLAUER, P, HASTINGS, K. E. M, MASSIE, B, PRESCOTT, S, PETROF, B. J, KARPATI, G

“…Replication-defective (E1-E3-deleted) human adenovirus vectors are a promising means of therapeutic gene delivery to skeletal muscle cells. Since the tropism…”
Get full text

Factors Influencing the Efficacy, Longevity, and Safety of Electroporation-Assisted Plasmid-Based Gene Transfer into Mouse Muscles by Molnar, Maria J, Gilbert, Rénald, Lu, Yifan, Liu, An-Bang, Guo, Athena, Larochelle, Nancy, Orlopp, Kristian, Lochmuller, Hanns, Petrof, Basil J, Nalbantoglu, Josephine, Karpati, George

“…Intramuscular injection of plasmid is a potential alternative to viral vectors for the transfer of therapeutic genes into skeletal muscle fibers. The low…”
Get full text

Impact of the coxsackie and adenovirus receptor (CAR) on glioma cell growth and invasion: Requirement for the C‐terminal domain by Huang, Kuo‐Cheng, Altinoz, Meric, Wosik, Karolina, Larochelle, Nancy, Koty, Zafiro, Zhu, Lixia, Holland, Paul C., Nalbantoglu, Josephine

“…Expression of the coxsackie and adenovirus receptor (CAR) is downregulated in malignant glioma cell lines and is barely detectable in high‐grade primary…”
Get full text

Efficient and fast functional screening of microdystrophin constructs in vivo and in vitro for therapy of duchenne muscular dystrophy by Jørgensen, Louise H, Larochelle, Nancy, Orlopp, Kristian, Dunant, Patrick, Dudley, Roy W R, Stucka, Rolf, Thirion, Christian, Walter, Maggie C, Laval, Steven H, Lochmüller, Hanns

“…Duchenne muscular dystrophy (DMD) is an X-linked, lethal genetic disorder affecting the skeletal muscle compartment, and is caused by mutation(s) in the…”
Get more information

Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice by Dunant, Patrick, Larochelle, Nancy, Thirion, Christian, Stucka, Rolf, Ursu, Daniel, Petrof, Basil J, Wolf, Eckhard, Lochmüller, Hanns

“…Successful gene therapy of Duchenne muscular dystrophy may require the lifelong expression of a therapeutic gene in all affected muscles. The most promising…”
Get full text

Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses by Larochelle, Nancy, Deol, Jatinderpal R, Srivastava, Vinit, Allen, Carol, Mizuguchi, Hiroyuki, Karpati, George, Holland, Paul C, Nalbantoglu, Josephine

“…Adenoviral vectors that use the coxsackievirus and adenovirus receptor do not transduce mature muscle efficiently. Group B adenoviruses use CD46 as their cell…”
Get more information

The Short MCK1350 Promoter/Enhancer Allows for Sufficient Dystrophin Expression in Skeletal Muscles of mdx Mice by Larochelle, Nancy, Oualikene, Wahiba, Dunant, Patrick, Massie, Bernard, Karpati, George, Nalbantoglu, Josephine, Lochmuller, Hanns

“…First-generation adenovirus vectors (AdV) have been used successfully to transfer a human dystrophin minigene to skeletal muscle of mdx mice. In most studies,…”
Get full text

Strategies for muscle-specific targeting of adenoviral gene transfer vectors by Thirion, Christian, Larochelle, Nancy, Volpers, Christoph, Dunant, Patrick, Stucka, Rolf, Holland, Paul, Nalbantoglu, Josephine, Kochanek, Stefan, Lochmüller, Hanns

“…Currently, adenoviral transfer of therapeutic genes such as dystrophin is hampered by low transduction efficiency of adult skeletal muscle. This is largely due…”
Get full text

Interferons impair early transgene expression by adenovirus-mediated gene transfer in muscle cells by ACSADI, G, O'HAGAN, D, LOCHMÜLLER, H, PRESCOTT, S, LAROCHELLE, N, NALBANTOGLU, J, JANI, A, KARPATI, G

“…Recombinant adenovirus (AVR) promises to be an efficient vector in gene therapy for neuromuscular diseases, but in preclinical experiments the expression of…”
Get full text

Subacute Neutropenia Treated by Splenectomy by Auger, C, Jobin, J B, Larochelle, L N

Get full text

Intercapillary glomerulosclerosis of Kimmelstiel and Wilson or glomerulohyalinosis of diabetics; clinical study by LAROCHELLE, L N

Get more information

Therapeutic aspects of various new antibiotics and of penicillin by LAROCHELLE, L N

Get more information

Hyperinsulinism due to adenoma of the pancreas by LAROCHELLE, L N, MORIN, Y

Get more information

La fatigue hypoglycémique by LAROCHELLE, L N

Get more information

Treatment of simple ocular paralysis by oral Echothiophate (phospholine iodide) by PLAMONDON, M, LAROCHELLE, L N

Get more information

Le thiouracil; aspect théorique et clinique by LAROCHELLE, L N, JOBIN, J

Get more information

Periarteritis nodosa and its treatment with corticotrophin by LAROCHELLE, L N, JULIEN, J M

Get more information

DISCUSSION ON THE ORAL TREATMENT OF DIABETES MELLITUS by ROBILLARD, R, LAROCHELLE, L N, PRUDHOMME, J, HOFFMAN, M

Get more information