Search Results - "Larman, Mark"

Deep learning versus manual morphology-based embryo selection in IVF: a randomized, double-blind noninferiority trial by Illingworth, Peter J., Venetis, Christos, Gardner, David K., Nelson, Scott M., Berntsen, Jørgen, Larman, Mark G., Agresta, Franca, Ahitan, Saran, Ahlström, Aisling, Cattrall, Fleur, Cooke, Simon, Demmers, Kristy, Gabrielsen, Anette, Hindkjær, Johnny, Kelley, Rebecca L., Knight, Charlotte, Lee, Lisa, Lahoud, Robert, Mangat, Manveen, Park, Hannah, Price, Anthony, Trew, Geoffrey, Troest, Bettina, Vincent, Anna, Wennerström, Susanne, Zujovic, Lyndsey, Hardarson, Thorir

“…To assess the value of deep learning in selecting the optimal embryo for in vitro fertilization, a multicenter, randomized, double-blind, noninferiority…”
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Vitrification of mouse embryos with super-cooled air by Larman, Mark G., Ph.D, Gardner, David K., Ph.D

“…Objective To develop a closed vitrification device (i.e., one that requires no direct contact with liquid nitrogen) for successful cryostorage of embryos…”
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Calcium-free vitrification reduces cryoprotectant-induced zona pellucida hardening and increases fertilization rates in mouse oocytes by Larman, Mark G, Sheehan, Courtney B, Gardner, David K

“…Despite the success of embryo cyropreservation, routine oocyte freezing has proved elusive with only around 200 children born since the first reported birth in…”
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Sex-related physiology of the preimplantation embryo by Gardner, David K., Larman, Mark G., Thouas, George A.

“…Male and female preimplantation mammalian embryos differ not only in their chromosomal complement, but in their proteome and subsequent metabolome. This…”
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PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development by Saunders, Christopher M, Larman, Mark G, Parrington, John, Cox, Llewellyn J, Royse, Jillian, Blayney, Lynda M, Swann, Karl, Lai, F Anthony

“…Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca(2+) oscillations that are essential for embryo development. The…”
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Analysis of oocyte physiology to improve cryopreservation procedures by Gardner, David K., Sheehan, Courtney B., Rienzi, Laura, Katz-Jaffe, Mandy, Larman, Mark G.

“…In contrast to the preimplantation mammalian embryo, it has been notoriously difficult to cryopreserve the metaphase II oocyte. The ability to store oocytes…”
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Role of Phospholipase C-ζ Domains in Ca2+-dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Cytoplasmic Ca2+ Oscillations by Nomikos, Michail, Blayney, Lynda M., Larman, Mark G., Campbell, Karen, Rossbach, Andreas, Saunders, Christopher M., Swann, Karl, Lai, F. Anthony

“…The sperm-specific phospholipase C-ζ (PLCζ) elicits fertilization-like Ca2+ oscillations and activation of embryo development when microinjected into mammalian…”
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Cryopreservation in ART and concerns with contamination during cryobanking by Larman, Mark G., Hashimoto, Shu, Morimoto, Yoshiharu, Gardner, David K.

“…The cryopreservation of gametes and embryos is vital to numerous fields of reproductive biology, including assisted human reproduction. With improved culture…”
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Exposure of mouse oocytes to 1,2-propanediol during slow freezing alters the proteome by Katz-Jaffe, Mandy G., Ph.D, Larman, Mark G., Ph.D, Sheehan, Courtney B., B.Sc, Gardner, David K., D.Phil

“…Objective To examine the effect of exposure to 1,2-propanediol (PrOH) on the mammalian oocyte proteome. Design Experimental study. Setting Research laboratory…”
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Ultrarapid vitrification of mouse oocytes and embryos by Larman, Mark G, Gardner, David K

“…Cryopreservation facilitates long-term storage of gametes and embryos for numerous purposes. For example, cryobanking of unique mouse strains, particularly…”
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The role of calcium in ABA‐induced gene expression and stomatal movements by Webb, Alex A. R., Larman, Mark G., Montgomery, Lucy T., Taylor, Jane E., Hetherington, Alistair M.

“…Summary There is much interest in the transduction pathways by which abscisic acid (ABA) regulates stomatal movements (ABA‐turgor signalling) and by which this…”
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Vitrification of mouse pronuclear oocytes with no direct liquid nitrogen contact by Larman, Mark G, Sheehan, Courtney B, Gardner, David K

“…The ability to routinely cryopreserve human oocytes and embryos represents a significant advancement in the field of assisted reproductive technology. Although…”
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Inhibiting MAP Kinase Activity Prevents Calcium Transients and Mitosis Entry in Early Sea Urchin Embryos by Philipova, Rada, Larman, Mark G., Leckie, Calum P., Harrison, Patrick K., Groigno, Laurence, Whitaker, Michael

“…A transient calcium increase triggers nuclear envelope breakdown (mitosis entry) in sea urchin embryos. Cdk1/cyclin B kinase activation is also known to be…”
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ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos by Philipova, Rada, Kisielewska, Jolanta, Lu, Pin, Larman, Mark, Huang, Jun-Yong, Whitaker, Michael

“…Fertilization of sea urchin eggs results in a large, transient increase in intracellular free Ca 2+ concentration that is responsible for re-initiation of the…”
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CURRENT GUIDELINES ON THE MOUSE EMBRYO ASSAY (MEA) CAN ALLOW SUBOPTIMAL PRODUCTS TO BE USED WITHIN IVF LABS by Strait, Erik, Cowan, Patrick, Krier, Emma, Lee, Hamilton, Updike, Allison Joy, Puc, Airam Mex, Larman, Mark

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MOUSE EMBRYO ASSAY (MEA): SHOWING THAT THE 1-CELL EMBRYO IS A MORE SENSITIVE STARTING POINT THAN THE 2-CELL by Cowan, Patrick, Allyn, Victoria, Krier, Emma, Lee, Hamilton, Strait, Erik, Updike, Allison Joy, Puc, Airam Mex, Larman, Mark

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EXTENDED EXPOSURE TIME TO EMBRYOGLUE™ Results IN IMPROVED MOUSE FETAL DEVELOPMENT by Joris, Hubert, Mestres, Enric, Acacio, Mònica, Casals, Alba, Costa-Borges, Nuno, Calderón, Gloria, Larman, Mark G.

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MOUSE EMBRYO ASSAY (MEA): IT’S NOT WHAT YOU DO, IT’S THE WAY THAT YOU DO IT by Vang, Pa, Carriere, Megan, Strait, Erik, Allyn, Victoria, Cowan, Patrick, Lee, Hamilton, Arab, Jennifer, Mex-Puc, Airam, Larman, Mark G.

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Appendix E: Rapid-i TM : Closed Vitrification Device by Vitrolife by Larman, Mark G

“…Cryopreservation of gametes and embryos is a growing technique in numerous reproductive fields including human-assisted reproduction. With improved…”
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Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles by Cimadomo, Danilo, Chiappetta, Viviana, Innocenti, Federica, Saturno, Gaia, Taggi, Marilena, Marconetto, Anabella, Casciani, Valentina, Albricci, Laura, Maggiulli, Roberta, Coticchio, Giovanni, Ahlström, Aisling, Berntsen, Jørgen, Larman, Mark, Borini, Andrea, Vaiarelli, Alberto, Ubaldi, Filippo Maria, Rienzi, Laura

“…Preimplantation genetic testing for aneuploidies (PGT-A) is arguably the most effective embryo selection strategy. Nevertheless, it requires greater workload,…”
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