Search Results - "Larijani, Mani"

A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket by King, Justin J, Larijani, Mani

“…Activation-induced cytidine deaminase (AID) and its relative APOBEC3 cytidine deaminases boost immune response by mutating immune or viral genes. Because of…”
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Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes by Grant, Michael, Larijani, Mani

“…APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host…”
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Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering by Ghorbani, Atefeh, Quinlan, Emma M, Larijani, Mani

“…The immune system is unique among all biological sub-systems in its usage of DNA-editing enzymes to introduce targeted gene mutations and double-strand DNA…”
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Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans by Quinlan, Emma M., King, Justin J., Amemiya, Chris T., Hsu, Ellen, Larijani, Mani

“…Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of antibodies in…”
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The biochemistry of activation-induced deaminase and its physiological functions by Larijani, Mani, Martin, Alberto

“…Highlights ► We discuss the evolution of AID within the APOBEC family of deaminases. ► We present a 3-dimensional model of AID and discuss structure–function…”
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Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut by Fritz, Jörg H., Rojas, Olga Lucia, Simard, Nathalie, McCarthy, Douglas D., Hapfelmeier, Siegfried, Rubino, Stephen, Robertson, Susan J., Larijani, Mani, Gosselin, Jean, Ivanov, Ivaylo I., Martin, Alberto, Casellas, Rafael, Philpott, Dana J., Girardin, Stephen E., McCoy, Kathy D., Macpherson, Andrew J., Paige, Christopher J., Gommerman, Jennifer L.

“…IgA secreting plasma cells in the lamina propria are shown to be an important source of iNOS and TNF required to maintain the homeostatic balance between…”
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Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AID by Larijani, Mani, Martin, Alberto

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway by Yoshioka, Ema, Chelakkot, Vipin Shankar, Licursi, Maria, Rutihinda, Suzette G, Som, Jayoti, Derwish, Leena, King, Justin J, Pongnopparat, Theerawat, Mearow, Karen, Larijani, Mani, Dorward, Ann M, Hirasawa, Kensuke

“…Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic…”
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Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish by Ghorbani, Atefeh, Khataeipour, S Javad, Solbakken, Monica H, Huebert, David N G, Khoddami, Minasadat, Eslamloo, Khalil, Collins, Cassandra, Hori, Tiago, Jentoft, Sissel, Rise, Matthew L, Larijani, Mani

“…Antibody affinity maturation in vertebrates requires the enzyme activation-induced cytidine deaminase (AID) which initiates secondary antibody diversification…”
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Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells by Monajemi, Mahdis, Woodworth, Claire F, Zipperlen, Katrin, Gallant, Maureen, Grant, Michael D, Larijani, Mani

“…Due to constitutive expression in cells targeted by human immunodeficiency virus (HIV), and immediate mode of viral restriction upon HIV entry into the host…”
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A licensing step links AID to transcription elongation for mutagenesis in B cells by Methot, Stephen P., Litzler, Ludivine C., Subramani, Poorani Ganesh, Eranki, Anil K., Fifield, Heather, Patenaude, Anne-Marie, Gilmore, Julian C., Santiago, Gabriel E., Bagci, Halil, Côté, Jean-François, Larijani, Mani, Verdun, Ramiro E., Di Noia, Javier M.

“…Activation-induced deaminase (AID) mutates the immunoglobulin ( Ig ) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B…”
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Characterization and Transcript Expression Analyses of Atlantic Cod Viperin by Eslamloo, Khalil, Ghorbani, Atefeh, Xue, Xi, Inkpen, Sabrina M, Larijani, Mani, Rise, Matthew L

“…Viperin is a key antiviral effector in immune responses of vertebrates including the Atlantic cod ( ). Using cloning, sequencing and gene expression analyses,…”
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AID, APOBEC3A and APOBEC3B efficiently deaminate deoxycytidines neighboring DNA damage induced by oxidation or alkylation by Diamond, Cody P., Im, Junbum, Button, Erynn A., Huebert, David N.G., King, Justin J., Borzooee, Faeze, Abdouni, Hala S., Bacque, Lisa, McCarthy, Erin, Fifield, Heather, Berghuis, Lesley M., Larijani, Mani

“…AID/APOBEC3 (A3) enzymes instigate genomic mutations that are involved in immunity and cancer. Although they can deaminate any deoxycytidine (dC) to…”
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Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys by Holland, Stephen J., Berghuis, Lesley M., King, Justin J., Iyer, Lakshminarayan M., Sikora, Katarzyna, Fifield, Heather, Peter, Sarah, Quinlan, Emma M., Sugahara, Fumiaki, Shingate, Prashant, Trancoso, Inês, Iwanami, Norimasa, Temereva, Elena, Strohmeier, Christine, Kuratani, Shigeru, Venkatesh, Byrappa, Evanno, Guillaume, Aravind, L., Schorpp, Michael, Larijani, Mani, Boehm, Thomas

“…Cytidine deaminases of the AID/APOBEC family catalyze C-to-U nucleotide transitions in mRNA or DNA. Members of the APOBEC3 branch are involved in antiviral…”
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Catalytic Pocket Inaccessibility of Activation-Induced Cytidine Deaminase Is a Safeguard against Excessive Mutagenic Activity by King, Justin J., Manuel, Courtney A., Barrett, Crystal V., Raber, Susanne, Lucas, Heather, Sutter, Patricia, Larijani, Mani

“…Activation-induced cytidine deaminase (AID) mutates cytidine to uridine at immunoglobulin loci to initiate secondary antibody diversification but also causes…”
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Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination by Zahn, Astrid, Eranki, Anil K., Patenaude, Anne-Marie, Methot, Stephen P., Fifield, Heather, Cortizas, Elena M., Foster, Paul, Imai, Kohsuke, Durandy, Anne, Larijani, Mani, Verdun, Ramiro E., Di Noia, Javier M.

“…Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by…”
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APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome by Borzooee, Faezeh, Joris, Krista D, Grant, Michael D, Larijani, Mani

“…APOBEC3G (A3G) is a host enzyme that mutates the genomes of retroviruses like HIV. Since A3G is expressed pre-infection, it has classically been considered an…”
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Zebrafish AID is capable of deaminating methylated deoxycytidines by Abdouni, Hala, King, Justin J, Suliman, Mussa, Quinlan, Matthew, Fifield, Heather, Larijani, Mani

“…Activation-induced cytidine deaminase (AID) deaminates deoxycytidine (dC) to deoxyuracil (dU) at immunoglobulin loci in B lymphocytes to mediate secondary…”
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The Concerted Action of Msh2 and UNG Stimulates Somatic Hypermutation at A · T Base Pairs by Frieder, Darina, Larijani, Mani, Collins, Cathy, Shulman, Marc, Martin, Alberto

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment by Monajemi, Mahdis, Woodworth, Claire F, Benkaroun, Jessica, Grant, Michael, Larijani, Mani

“…The enzyme APOBEC3G (A3G) mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine (dC) to deoxyuridine (dU) on minus strand viral DNA…”
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