Search Results - "Larhammar, Martin"

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons by Larhammar, Martin, Huntwork-Rodriguez, Sarah, Rudhard, York, Sengupta-Ghosh, Arundhati, Lewcock, Joseph W

“…The c-Jun- -terminal kinase (JNK) signaling pathway regulates nervous system development, axon regeneration, and neuronal degeneration after acute injury or in…”
Get full text

Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice by Andersson, Lisa S., Larhammar, Martin, Memic, Fatima, Wootz, Hanna, Schwochow, Doreen, Rubin, Carl-Johan, Patra, Kalicharan, Arnason, Thorvaldur, Wellbring, Lisbeth, Hjälm, Göran, Imsland, Freyja, Petersen, Jessica L., McCue, Molly E., Mickelson, James R., Cothran, Gus, Ahituv, Nadav, Roepstorff, Lars, Mikko, Sofia, Vallstedt, Anna, Lindgren, Gabriella, Andersson, Leif, Kullander, Klas

“…A premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses, and the Dmrt3 transcription factor is critical in the…”
Get full text

Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits by Perry, Sharn, Larhammar, Martin, Vieillard, Jennifer, Nagaraja, Chetan, Hilscher, Markus M, Tafreshiha, Atieh, Rofo, Fadi, Caixeta, Fabio V, Kullander, Klas

“…Neuronal networks within the spinal cord, collectively known as the central pattern generator (CPG), coordinate rhythmic movements underlying locomotion. The…”
Get full text

Alterations in the motor neuron-renshaw cell circuit in the Sod1G93A mouse model by Wootz, Hanna, FitzSimons-Kantamneni, Eileen, Larhammar, Martin, Rotterman, Travis M., Enjin, Anders, Patra, Kalicharan, André, Elodie, Van Zundert, Brigitte, Kullander, Klas, Alvarez, Francisco J.

“…Motor neurons become hyperexcitable during progression of amyotrophic lateral sclerosis (ALS). This abnormal firing behavior has been explained by changes in…”
Get full text

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult by Larhammar, Martin, Huntwork-Rodriguez, Sarah, Jiang, Zhiyu, Solanoy, Hilda, Sengupta Ghosh, Arundhati, Wang, Bei, Kaminker, Joshua S, Huang, Kevin, Eastham-Anderson, Jeffrey, Siu, Michael, Modrusan, Zora, Farley, Madeline M, Tessier-Lavigne, Marc, Lewcock, Joseph W, Watkins, Trent A

“…The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the…”
Get full text

SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis by Larhammar, Martin, Patra, Kalicharan, Blunder, Martina, Emilsson, Lina, Peuckert, Christiane, Arvidsson, Emma, Rönnlund, Daniel, Preobraschenski, Julia, Birgner, Carolina, Limbach, Christoph, Widengren, Jerker, Blom, Hans, Jahn, Reinhard, Wallén-Mackenzie, Åsa, Kullander, Klas

“…Abstract Background The neuromodulatory transmitters, biogenic amines, have profound effects on multiple neurons and are essential for normal behavior and…”
Get full text

Cell Death and Neurodegeneration by Andreone, Benjamin J, Larhammar, Martin, Lewcock, Joseph W

“…Neurodegenerative disease is characterized by the progressive deterioration of neuronal function caused by the degeneration of synapses, axons, and ultimately…”
Get full text

SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons by Miyamoto, Takashi, Kim, Chaeyoung, Chow, Johann, Dugas, Jason C., DeGroot, Jack, Bagdasarian, Alex L., Thottumkara, Arun P., Larhammar, Martin, Calvert, Meredith EK, Fox, Brian M., Lewcock, Joseph W., Kane, Lesley A.

“…Sterile alpha and toll/interleukin receptor motif-containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD+…”
Get full text

Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents I h and I SK by Perry, Sharn, Gezelius, Henrik, Larhammar, Martin, Hilscher, Markus M., Lamotte d'Incamps, Boris, Leao, Katarina E., Kullander, Klas

“…Abstract Renshaw cells in the spinal cord ventral horn regulate motoneuron output through recurrent inhibition. Renshaw cells can be identified in vitro using…”
Get full text

Developmental Disruption of Recurrent Inhibitory Feedback Results in Compensatory Adaptation in the Renshaw Cell-Motor Neuron Circuit by Enjin, Anders, Perry, Sharn, Hilscher, Markus M, Nagaraja, Chetan, Larhammar, Martin, Gezelius, Henrik, Eriksson, Anders, Leão, Katarina E, Kullander, Klas

“…When activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons. The…”
Get full text

Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model by Wootz, Hanna, Fitzsimons-Kantamneni, Eileen, Larhammar, Martin, Rotterman, Travis M, Enjin, Anders, Patra, Kalicharan, André, Elodie, Van Zundert, Brigitte, Kullander, Klas, Alvarez, Francisco J

“…Motor neurons become hyperexcitable during progression of amyotrophic lateral sclerosis (ALS). This abnormal firing behavior has been explained by changes in…”
Get full text

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis by Craig, Robert A., Fox, Brian M., Hu, Cheng, Lexa, Katrina W., Osipov, Maksim, Thottumkara, Arun P., Larhammar, Martin, Miyamoto, Takashi, Rana, Anil, Kane, Lesley A., Yulyaningsih, Ernie, Solanoy, Hilda, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kajiwara, Yuji, Fleck, Daniel, Lucas, Anthony, Haddick, Patrick C. G., Takahashi, Ryan H., Tong, Vincent, Wang, Jing, Canet, Mark J., Poda, Suresh B., Scearce-Levie, Kimberly, Srivastava, Ankita, Sweeney, Zachary K., Xu, Musheng, Zhang, Rui, He, Jianrong, Lei, Yanan, Zhuo, Zheng, de Vicente, Javier

“…Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a…”
Get full text

Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents Ih and ISK by Perry, Sharn, Gezelius, Henrik, Larhammar, Martin, Hilscher, Markus M., Lamotte d'Incamps, Boris, Leao, Katarina E., Kullander, Klas

“…Renshaw cells in the spinal cord ventral horn regulate motoneuron output through recurrent inhibition. Renshaw cells can be identified in vitro using…”
Get full text

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response by Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick CG, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandmann, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

“…The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although…”
Get full text

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response by Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick C G, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

“…The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although…”
Get full text

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth by Markljung, Ellen, Jiang, Lin, Jaffe, Jacob D, Mikkelsen, Tarjei S, Wallerman, Ola, Larhammar, Martin, Zhang, Xiaolan, Wang, Li, Saenz-Vash, Veronica, Gnirke, Andreas, Lindroth, Anders M, Barrés, Romain, Yan, Jie, Strömberg, Sara, De, Sachinandan, Pontén, Fredrik, Lander, Eric S, Carr, Steven A, Zierath, Juleen R, Kullander, Klas, Wadelius, Claes, Lindblad-Toh, Kerstin, Andersson, Göran, Hjälm, Göran, Andersson, Leif

“…A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal…”
Get full text

Functional and histological outcome after focal traumatic brain injury is not improved in conditional EphA4 knockout mice by Hånell, Anders, Clausen, Fredrik, Djupsjö, Anders, Vallstedt, Anna, Patra, Kalicharan, Israelsson, Charlotte, Larhammar, Martin, Björk, Maria, Paixão, Sónia, Kullander, Klas, Marklund, Niklas

“…We investigated the role of the axon guidance molecule EphA4 following traumatic brain injury (TBI) in mice. Neutralization of EphA4 improved motor function…”
Get more information

Alterations in the motor neuron-renshaw cell circuit in the Sod1 super(G93A) mouse model by Wootz, Hanna, FitzSimons-Kantamneni, Eileen, Larhammar, Martin, Rotterman, Travis M, Enjin, Anders, Patra, Kalicharan, Andre, Elodie, Van Zundert, Brigitte, Kullander, Klas, Alvarez, Francisco J

“…Motor neurons become hyperexcitable during progression of amyotrophic lateral sclerosis (ALS). This abnormal firing behavior has been explained by changes in…”
Get full text

Alterations in the motor neuron–renshaw cell circuit in the Sod1 G93A mouse model by Wootz, Hanna, FitzSimons‐Kantamneni, Eileen, Larhammar, Martin, Rotterman, Travis M., Enjin, Anders, Patra, Kalicharan, André, Elodie, Van Zundert, Brigitte, Kullander, Klas, Alvarez, Francisco J.

“…Abstract Motor neurons become hyperexcitable during progression of amyotrophic lateral sclerosis (ALS). This abnormal firing behavior has been explained by…”
Get full text

Alterations in the motor neuron–renshaw cell circuit in the Sod1 G93A mouse model by Wootz, Hanna, FitzSimons‐Kantamneni, Eileen, Larhammar, Martin, Rotterman, Travis M., Enjin, Anders, Patra, Kalicharan, André, Elodie, Van Zundert, Brigitte, Kullander, Klas, Alvarez, Francisco J.

“…Abstract Motor neurons become hyperexcitable during progression of amyotrophic lateral sclerosis (ALS). This abnormal firing behavior has been explained by…”
Get full text