Submicroscopic Falciparum Malaria in Febrile Individuals in Urban and Rural Areas of Gabon

AbstractCharacterization of the parasite reservoir is required to improve malaria control. Asymptomatic patients with subpatent parasitemia have been identified in Gabon, but the prevalence of such infections among febrile subjects is unclear. We assessed the prevalence of submicroscopic infections...

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Published in:	The American journal of tropical medicine and hygiene Vol. 96; no. 4; pp. 815 - 818
Main Authors:	Mawili-Mboumba, Denise P, Ndong, Rosalie Nikiéma, Rosa, Noemi Bahamontes, Largo, Jose Luis Llergo, Lembet-Mikolo, Aude, Nzamba, Prycil, Mbouoronde, Christelle Offouga, Kombila, Maryvonne, Bouyou Akotet, Marielle K
Format:	Journal Article
Language:	English
Published:	United States The American Society of Tropical Medicine and Hygiene 05-04-2017
Subjects:	Child Child, Preschool Female Gabon - epidemiology Humans Infant Malaria, Falciparum - blood Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Male Microscopy Plasmodium falciparum - genetics RNA, Protozoan RNA, Ribosomal, 18S - genetics Rural Population Urban Population
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Summary:	AbstractCharacterization of the parasite reservoir is required to improve malaria control. Asymptomatic patients with subpatent parasitemia have been identified in Gabon, but the prevalence of such infections among febrile subjects is unclear. We assessed the prevalence of submicroscopic infections on an island (Port-Gentil), and in urban (Libreville), semiurban (Melen), and rural (Oyem) settings in Gabon. Blood samples ( = 310) from febrile patients were tested for malaria parasites by quantitative nucleic acid sequence-based amplification (QT-NASBA). Parasites were detected in 55.8% (173/310) of samples by microscopy and in 66.4% (206/310) of samples by 18S rRNA QT-NASBA. The proportion of submicroscopic infections differed considerably between sites. Gametocytes were found in 1% (3/310) of the individuals by microscopy and in 32% (99/310) by mRNA QT-NASBA. Thus, submicroscopic parasitemia is frequent in febrile patients, and the detection of this condition is important, to improve disease control.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9637 1476-1645
DOI:	10.4269/ajtmh.15-0231