Search Results - "Larghero Jerome"

Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products by Mebarki, Miryam, Abadie, Camille, Larghero, Jérôme, Cras, Audrey

“…Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed,…”
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Full circumferential human tracheal replacement: a systematic review by Thierry, Briac, Arakelian, Lousineh, Denoyelle, Françoise, Larghero, Jérôme, Wurtz, Alain

“…Summary Full Circumferential Tracheal Replacement (FCTR) is a surgical challenge, indicated in rare cases of extensive tracheal resection, with no consensus on…”
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Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations by Chabannon, Christian, Larghero, Jérôme

“…Access to treatment with CAR-T Cells at European hospitals in general and at French hospitals in particular remains limited, when compared with the situation…”
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Cancer Cell De-Differentiation: Plasticity-Driven Stratagem For Tumor Metastasis and Recurrence by El Marsafy, Sanaa, Larghero, Jérôme

“…Tumor recurrence is a colossal challenge in clinical oncology. This multifactorial problem is attributed to the emergence of additional genetic mutations and…”
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Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling by Lordier, Larissa, Jalil, Abdelali, Aurade, Fréderic, Larbret, Fréderic, Larghero, Jerôme, Debili, Najet, Vainchenker, William, Chang, Yunhua

“…Megakaryocyte (MK) is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis, which was a process considered to be…”
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Circadian Clock Genes Modulate Human Bone Marrow Mesenchymal Stem Cell Differentiation, Migration and Cell Cycle by Boucher, Helene, Vanneaux, Valerie, Domet, Thomas, Parouchev, Alexandre, Larghero, Jerome

“…Many of the components that regulate the circadian clock have been identified in organisms and humans. The influence of circadian rhythm (CR) on the regulation…”
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Effect of early granulocyte-colony-stimulating factor administration in the prevention of febrile neutropenia and impact on toxicity and efficacy of anti-CD19 CAR-T in patients with relapsed/refractory B-cell lymphoma by Liévin, Raphaël, Di Blasi, Roberta, Morin, Florence, Galli, Eugenio, Allain, Vincent, De Jorna, Romain, Vercellino, Laetitia, Parquet, Nathalie, Mebarki, Miryam, Larghero, Jerome, de Kerviler, Eric, Madelaine, Isabelle, Caillat-Zucman, Sophie, Chevret, Sylvie, Thieblemont, Catherine

“…Chimeric Antigen Receptor T cells (CAR-T) are an outbreaking treatment option for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Cytokine…”
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The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation by Beaupere, Carine, Garcia, Marie, Larghero, Jerome, Fève, Bruno, Capeau, Jacqueline, Lagathu, Claire

“…Summary To maintain bone mass turnover and bone mineral density (BMD), bone marrow (BM) mesenchymal stem cells (MSCs) are constantly recruited and subsequently…”
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Biofabrication of an Esophageal Tissue Construct from a Polymer Blend Using 3D Extrusion‐Based Printing by Farhat, Wissam, Ayollo, Dmitry, Arakelian, Lousineh, Thierry, Briac, Mazari-Arrighi, Elsa, Caputo, Valentino, Faivre, Lionel, Cattan, Pierre, Larghero, Jérôme, Chatelain, Francois, Fuchs, Alexandra

“…Many tissue engineering approaches are being explored to offer solutions for diseased esophageal tissue and its repair. However, classical techniques in tissue…”
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Feasibility of an acoustophoresis-based system for a high-throughput cell washing: application to bioproduction by Sugier, Hugo R., Bellebon, Ludovic, Aider, Jean-Luc, Larghero, Jérôme, Peltzer, Juliette, Martinaud, Christophe

“…These last decades have seen the emergence and development of cell-based therapies, notably those based on mesenchymal stromal cells (MSCs). The advancement of…”
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How to decrease bone marrow collection volume and risk contaminations via the operating room cell concentration? by Grimaud, Yoann, Sicre de Fontbrune, Flore, Michonneau, David, Desnoyer, Aude, Peffault de Latour, Régis, Larghero, Jérôme, Nasone, Justine, Faivre, Lionel

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Proplatelet formation is regulated by the Rho/ROCK pathway by Chang, Yunhua, Auradé, Frédéric, Larbret, Frédéric, Zhang, Yanyan, Le Couedic, Jean-Pierre, Momeux, Laurence, Larghero, Jerôme, Bertoglio, Jacques, Louache, Fawzia, Cramer, Elisabeth, Vainchenker, William, Debili, Najet

“…Platelets are released by megakaryocytes (MKs) via cytoplasmic extensions called proplatelets, which require profound changes in the microtubule and actin…”
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Banking or Bankrupting: Strategies for Sustaining the Economic Future of Public Cord Blood Banks by Magalon, Jeremy, Maiers, Martin, Kurtzberg, Joanne, Navarrete, Cristina, Rubinstein, Pablo, Brown, Colin, Schramm, Catherine, Larghero, Jérome, Katsahian, Sandrine, Chabannon, Christian, Picard, Christophe, Platz, Alexander, Schmidt, Alexander, Katz, Gregory

“…Cord blood is an important source of stem cells. However, nearly 90% of public cord blood banks have declared that they are struggling to maintain their…”
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Advanced therapy medicinal products: Regulatory framework, hospital and pharmaceutical circuits in Europe and France by Mebarki, Miryam, Madelaine, Isabelle, Larghero, Jérôme, de Jorna, Romain

“…Advanced therapy medicinal products (ATMPs) represent a new class of biological medicines. The European regulation has classified ATMPs into three categories:…”
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CAR-T cells gene therapy medicines: Regulatory status and pharmaceutical circuits in Europe and France by de Jorna, Romain, Madelaine, Isabelle, Larghero, Jérôme, Mebarki, Miryam

“…CAR-T cells belong to a new class of biological medicines, referred to as Advanced Therapy Medicinal Products (ATMPs). Despite the cellular component,…”
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Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance by Moras, Martina, Hattab, Claude, Gonzalez-Menendez, Pedro, Fader, Claudio M, Dussiot, Michael, Larghero, Jerome, Le Van Kim, Caroline, Kinet, Sandrina, Taylor, Naomi, Lefevre, Sophie D, Ostuni, Mariano A

“…Erythroblast maturation in mammals is dependent on organelle clearance throughout terminal erythropoiesis. We studied the role of the outer mitochondrial…”
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Understanding the Angiogenic Characteristics of Clinical-Grade Mesenchymal Stromal Cells Isolated from Human Umbilical Cord by Carcopino, Charlotte, Rossi, Elisa, Mebarki, Miryam, El Hamaoui, Divina, Gaussem, Pascale, Larghero, Jérôme, Smadja, David M, Cras, Audrey

“…Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on…”
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Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation during Human Terminal Erythropoiesis by Moras, Martina, Hattab, Claude, Gonzalez-Menendez, Pedro, Martino, Suella, Larghero, Jerome, Le Van Kim, Caroline, Kinet, Sandrina, Taylor, Naomi, Lefevre, Sophie D, Ostuni, Mariano A

“…Translocator protein (TSPO) and voltage dependent anion channels (VDAC) are two proteins forming a macromolecular complex in the outer mitochondrial membrane…”
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Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis by Alhaj Hussen, Kutaiba, Vu Manh, Thien-Phong, Guimiot, Fabien, Nelson, Elisabeth, Chabaane, Emna, Delord, Marc, Barbier, Maxime, Berthault, Claire, Dulphy, Nicolas, Alberdi, Antonio José, Burlen-Defranoux, Odile, Socié, Gerard, Bories, Jean Christophe, Larghero, Jerôme, Vanneaux, Valérie, Verhoeyen, Els, Wirth, Thierry, Dalod, Marc, Gluckman, Jean Claude, Cumano, Ana, Canque, Bruno

“…The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid…”
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Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis by Keita, Seydou, Diop, Samuel, Lekiashvili, Shalva, Chabaane, Emna, Nelson, Elisabeth, Strullu, Marion, Arfeuille, Chloé, Guimiot, Fabien, Domet, Thomas, Duchez, Sophie, Evrard, Bertrand, Darde, Thomas, Larghero, Jerome, Verhoeyen, Els, Cumano, Ana, Macintyre, Elizabeth A., Kasraian, Zeinab, Jouen, François, Goodhardt, Michele, Garrick, David, Chalmel, Frederic, Alhaj Hussen, Kutaiba, Canque, Bruno

“…Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that human lymphopoiesis is…”
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