Search Results - "Large, Roddy J."

Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal by Fedigan, Stephen, Bradley, Eamonn, Webb, Timothy, Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca 2+ -activated Cl − currents ( I ClCa ) that are important for the development of…”
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The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Baker, Salah A., Harvey, Brian J., McHale, Noel G., Sergeant, Gerard P.

“…Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment by Webb, Timothy I., Kshatri, Aravind Singh, Large, Roddy J., Akande, Adebola Morayo, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Significance Large-conductance Ca ²⁺-activated K ⁺ (BK) calcium-activated potassium channels alter the excitability of a wide variety of cells including nerves…”
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LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels by Dudem, Srikanth, Large, Roddy J., Kulkarni, Shruti, McClafferty, Heather, Tikhonova, Irina G., Sergeant, Gerard P., Thornbury, Keith D., Shipston, Michael J., Perrino, Brian A., Hollywood, Mark A.

“…LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson’s disease (PD) and Essential Tremor (ET). Patients with…”
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Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC by Fong, Zhihui, Griffin, Caoimhín S., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Sergeant, Gerard P.

“…P2X1 receptors are adenosine triphosphate (ATP)-gated cation channels that are functionally important for male fertility, bladder contraction, and platelet…”
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LINGO1 is a regulatory subunit of large conductance, Ca 2+ -activated potassium channels by Dudem, Srikanth, Large, Roddy J, Kulkarni, Shruti, McClafferty, Heather, Tikhonova, Irina G, Sergeant, Gerard P, Thornbury, Keith D, Shipston, Michael J, Perrino, Brian A, Hollywood, Mark A

“…LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson's disease (PD) and Essential Tremor (ET). Patients with…”
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The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T, Large, Roddy J, Hollywood, Mark A, Thornbury, Keith D, Baker, Salah A, Harvey, Brian J, McHale, Noel G, Sergeant, Gerard P

“…Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed interstitial…”
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The role of Ca 2+ -activated Cl - current in tone generation in the rabbit corpus cavernosum by Hannigan, Karen I, Griffin, Caoimhin S, Large, Roddy J, Sergeant, Gerard P, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D

“…Rabbit corpus cavernosum smooth muscle (RCCSM) cells express ion channels that produce Ca -activated Cl ( ) current, but low sensitivity to conventional…”
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Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels by Roy, Subhrangsu, Large, Roddy J., Akande, Adebola Morayo, Kshatri, Aravind, Webb, Tim I., Domene, Carmen, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…We have designed, synthesised and characterised the effects of a number of novel anthraquinone derivatives and assessed their effects on large conductance,…”
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Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels by Kshatri, Aravind S., Li, Qin, Yan, Jiusheng, Large, Roddy J., Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Large conductance, voltage and Ca 2+ activated K + channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth…”
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Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J., Webb, Tim I., Camarasu, Costin, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo‐SR family. Their effects on bladder smooth muscle BK channels…”
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Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J, Webb, Tim I, Camarasu, Costin, Sergeant, Gerard P, McHale, Noel G, Thornbury, Keith D, Hollywood, Mark A

“…Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels…”
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Differential efficacy of GoSlo-SR compounds on BKα and BKαγ 1-4 channels by Kshatri, Aravind S, Li, Qin, Yan, Jiusheng, Large, Roddy J, Sergeant, Gerard P, McHale, Noel G, Thornbury, Keith D, Hollywood, Mark A

“…Large conductance, voltage and Ca activated K channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth muscle…”
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Inside Cover: Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family (ChemMedChem 10/2012) by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J., Webb, Tim I., Camarasu, Costin, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

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The role of Ca 2+ influx in spontaneous Ca 2+ wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Baker, Salah A., Harvey, Brian J., McHale, Noel G., Sergeant, Gerard P.

“…Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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The role of Ca super(2+) influx in spontaneous Ca super(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T, Large, Roddy J, Hollywood, Mark A, Thornbury, Keith D, Baker, Salah A, Harvey, Brian J, McHale, Noel G, Sergeant, Gerard P

“…Key points * Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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Mutations in the S4/S5 Linker and S6 of Slo1 Ablate the Response to the Novel BK Channel Opener GoSlo-SR-5-6 by Kshatri, Arvind, Webb, Tim I., Large, Roddy J., Morayo Akande, Adebola, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

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Inside Cover: Structure–Activity Relationships of a Novel Group of Large‐Conductance Ca 2+ ‐Activated K + (BK) Channel Modulators: The GoSlo‐SR Family (ChemMedChem 10/2012) by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J., Webb, Tim I., Camarasu, Costin, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

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Structure–Activity Relationships of a Novel Group of Large‐Conductance Ca 2+ ‐Activated K + (BK) Channel Modulators: The GoSlo‐SR Family by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J., Webb, Tim I., Camarasu, Costin, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

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Microarray comparison of normal and W / W v mice in the gastric fundus indicates a supersensitive phenotype by Sergeant, Gerard P., Large, Roddy J., Beckett, Elizabeth A. H., McGeough, Cathrine M., Ward, Sean M., Horowitz, Burton

“…Interstitial cells of Cajal (ICC) have been identified in specific areas throughout the smooth musculature of the gastrointestinal (GI) tract. Located within…”
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