Search Results - "Larbret, Fréderic"

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling by Lordier, Larissa, Jalil, Abdelali, Aurade, Fréderic, Larbret, Fréderic, Larghero, Jerôme, Debili, Najet, Vainchenker, William, Chang, Yunhua

“…Megakaryocyte (MK) is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis, which was a process considered to be…”
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Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach by Raslova, Hana, Kauffmann, Audrey, Sekkaï, Dalila, Ripoche, Hugues, Larbret, Fréderic, Robert, Thomas, Le Roux, Diana Tronik, Kroemer, Guido, Debili, Najet, Dessen, Philippe, Lazar, Vladimir, Vainchenker, William

“…Polyploidization is a part of the normal developmental process leading to platelet production during megakaryocyte (MK) differentiation. Ploidization is mainly…”
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Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens by Martínez, María Carmen, Larbret, Fréderic, Zobairi, Fatiha, Coulombe, Josée, Debili, Najet, Vainchenker, William, Ruat, Martial, Freyssinet, Jean-Marie

“…Hedgehog (Hh) proteins are considered diffusible morphogens that can be membrane anchored, playing an essential role during development. Here we show that Hh…”
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P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1 by Gilles, Laure, Guièze, Romain, Bluteau, Dominique, Cordette-Lagarde, Véronique, Lacout, Catherine, Favier, Rémi, Larbret, Fréderic, Debili, Najet, Vainchenker, William, Raslova, Hana

“…The molecular mechanisms that regulate megakaryocyte (MK) ploidization are poorly understood. Using MK differentiation from primary human CD34+ cells, we…”
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Impact of rising seawater temperature on a phagocytic cell population during V. parahaemolyticus infection in the sea anemone E. pallida by Billaud, Mélanie, Larbret, Frédéric, Czerucka, Dorota

“…Climate change is increasing ocean temperatures and consequently impacts marine life (e.g., bacterial communities). In this context, studying host-pathogen…”
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Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells by BEN SAHRA, Issam, LAURENT, Kathiane, DECKERT, Marcel, AUBERGER, Patrick, TANTI, Jean-François, BOST, Frédéric, GIULIANO, Sandy, LARBRET, Frédéric, PONZIO, Gilles, GOUNON, Pierre, LE MARCHAND-BRUSTEL, Yannick, GIORGETTI-PERALDI, Sophie, CORMONT, Mireille, BERTOLOTTO, Corine

“…Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and…”
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Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma by Berestjuk, Ilona, Lecacheur, Margaux, Carminati, Alexandrine, Diazzi, Serena, Rovera, Christopher, Prod’homme, Virginie, Ohanna, Mickael, Popovic, Ana, Mallavialle, Aude, Larbret, Frédéric, Pisano, Sabrina, Audebert, Stéphane, Passeron, Thierry, Gaggioli, Cédric, Girard, Christophe A, Deckert, Marcel, Tartare‐Deckert, Sophie

“…Resistance to BRAF/MEK inhibitor therapy in BRAF V600 ‐mutated advanced melanoma remains a major obstacle that limits patient benefit. Microenvironment…”
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A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma by Girard, Christophe A, Lecacheur, Margaux, Ben Jouira, Rania, Berestjuk, Ilona, Diazzi, Serena, Prod'homme, Virginie, Mallavialle, Aude, Larbret, Frédéric, Gesson, Maéva, Schaub, Sébastien, Pisano, Sabrina, Audebert, Stéphane, Mari, Bernard, Gaggioli, Cédric, Leucci, Eleonora, Marine, Jean-Christophe, Deckert, Marcel, Tartare-Deckert, Sophie

“…Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with therapy failure…”
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A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell–derived primitive hematopoiesis by Klimchenko, Olena, Mori, Marcella, DiStefano, Antonio, Langlois, Thierry, Larbret, Frédéric, Lecluse, Yann, Feraud, Olivier, Vainchenker, William, Norol, Françoise, Debili, Najet

“…The megakaryocytic (MK) and erythroid lineages are tightly associated during differentiation and are generated from a bipotent megakaryocyte-erythroid…”
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Proplatelet formation is regulated by the Rho/ROCK pathway by Chang, Yunhua, Auradé, Frédéric, Larbret, Frédéric, Zhang, Yanyan, Le Couedic, Jean-Pierre, Momeux, Laurence, Larghero, Jerôme, Bertoglio, Jacques, Louache, Fawzia, Cramer, Elisabeth, Vainchenker, William, Debili, Najet

“…Platelets are released by megakaryocytes (MKs) via cytoplasmic extensions called proplatelets, which require profound changes in the microtubule and actin…”
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Deubiquitinase Inhibitors Impair Leukemic Cell Migration Through Cofilin Oxidation and Alteration of Actin Reorganization by Larbret, Frédéric, Biber, Pierric, Dubois, Nicholas, Ivanov, Stoyan, Lafanechere, Laurence, Tartare-Deckert, Sophie, Deckert, Marcel

“…Actin networks are dynamically regulated through constant depolymerization and polymerization cycles. Although the fundamental mechanisms that govern these…”
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CD99 isoforms regulate CD1a expression in human monocyte‐derived DCs through ATF‐2/CREB‐1 phosphorylation by Mahiddine, Karim, Mallavialle, Aude, Bziouech, Hanen, Larbret, Frédéric, Bernard, Alain, Bernard, Ghislaine

“…CD1a expression is considered one of the major characteristics qualifying in vitro human dendritic cells (DCs) during their generation process. Here, we report…”
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Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma by Diazzi, Serena, Baeri, Alberto, Fassy, Julien, Lecacheur, Margaux, Marin‐Bejar, Oskar, Girard, Christophe A, Lefevre, Lauren, Lacoux, Caroline, Irondelle, Marie, Mounier, Carine, Truchi, Marin, Couralet, Marie, Ohanna, Mickael, Carminati, Alexandrine, Berestjuk, Ilona, Larbret, Frederic, Gilot, David, Vassaux, Georges, Marine, Jean‐Christophe, Deckert, Marcel, Mari, Bernard, Tartare‐Deckert, Sophie

“…Lineage dedifferentiation toward a mesenchymal‐like state displaying myofibroblast and fibrotic features is a common mechanism of adaptive and acquired…”
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Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells by Dirat, Béatrice, Ader, Isabelle, Golzio, Muriel, Massa, Fabienne, Mettouchi, Amel, Laurent, Kathiane, Larbret, Frédéric, Malavaud, Bernard, Cormont, Mireille, Lemichez, Emmanuel, Cuvillier, Olivier, Tanti, Jean François, Bost, Frédéric

“…Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug…”
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Nanoblades allow high-level genome editing in murine and human organoids by Tiroille, Victor, Krug, Adrien, Bokobza, Emma, Kahi, Michel, Bulcaen, Mattijs, Ensinck, Marjolein M., Geurts, Maarten H., Hendriks, Delilah, Vermeulen, François, Larbret, Frédéric, Gutierrez-Guerrero, Alejandra, Chen, Yu, Van Zundert, Indra, Rocha, Susana, Rios, Anne C., Medaer, Louise, Gijsbers, Rik, Mangeot, Philippe E., Clevers, Hans, Carlon, Marianne S., Bost, Frédéric, Verhoeyen, Els

“…Genome engineering has become more accessible thanks to the CRISPR-Cas9 gene-editing system. However, using this technology in synthetic organs called…”
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The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera by Dupont, Sabrina, Massé, Aline, James, Chloé, Teyssandier, Irène, Lécluse, Yann, Larbret, Frédéric, Ugo, Valérie, Saulnier, Patrick, Koscielny, Serge, Le Couédic, Jean Pierre, Casadevall, Nicole, Vainchenker, William, Delhommeau, François

“…The JAK2 617V>F mutation is frequent in polycythemia vera (PV) and essential thrombocythemia (ET). Using quantitative polymerase chain reaction (PCR), we found…”
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Saccharomyces boulardii Strain CNCM I-745 Modifies the Mononuclear Phagocytes Response in the Small Intestine of Mice Following Salmonella Typhimurium Infection by Ibáñez, Lidia, Pontier-Bres, Rodolphe, Larbret, Frederic, Rekima, Akila, Verhasselt, Valérie, Blin-Wakkach, Claudine, Czerucka, Dorota

“…Intestinal mononuclear phagocytes (MPs) comprise dendritic cells (DCs) and macrophages (Mφs) that play different roles in response to infection. After…”
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Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis by Chaligné, Ronan, James, Chloé, Tonetti, Carole, Besancenot, Rodolphe, Le Couédic, Jean Pierre, Fava, Fanny, Mazurier, Fréderic, Godin, Isabelle, Maloum, Karim, Larbret, Frédéric, Lécluse, Yann, Vainchenker, William, Giraudier, Stéphane

“…The MPL (W515L and W515K) mutations have been detected in granulocytes of patients suffering from certain types of primitive myelofibrosis (PMF). It is still…”
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Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process by Lordier, Larissa, Chang, Yunhua, Jalil, Abdelali, Aurade, Frédéric, Garçon, Loïc, Lécluse, Yann, Larbret, Frédéric, Kawashima, Toshiyuki, Kitamura, Toshio, Larghero, Jérôme, Debili, Najet, Vainchenker, William

“…Polyploidization of megakaryocytes (MKs), the platelet precursors, occurs by endomitosis, a mitotic process that fails at late stages of cytokinesis…”
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Technical Advance: Actin CytoFRET, a novel FRET flow cytometry method for detection of actin dynamics in resting and activated T cell by Larbret, Frédéric, Dubois, Nicholas, Brau, Frédéric, Guillemot, Elodie, Mahiddine, Karim, Tartare‐Deckert, Sophie, Verhasselt, Valérie, Deckert, Marcel

“…Actin CytoFRET represents a novel real‐time quantitative method to study actin cytoskeleton dynamics in intact T cell by flow cytometry. Actin cytoskeleton…”
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