Search Results - "Larbig, Gregor"

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping by Larbig, Gregor, Pickhardt, Marcus, Lloyd, David G, Schmidt, Boris, Mandelkow, Eckhard

“…The aggregation of tau protein into paired helical filaments is one of the hallmarks of Alzheimer's disease and related dementias. We therefore continue our…”
Get more information

Inhibitors and modulators of beta- and gamma-secretase by Schmidt, Boris, Baumann, Stefanie, Braun, Hannes A, Larbig, Gregor

“…Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as potential cause. The beta- and gamma-secretases…”
Get more information

Renal Targeting: Peptide-Based Drug Delivery to Proximal Tubule Cells by Wischnjow, Artjom, Sarko, Dikran, Janzer, Maria, Kaufman, Christina, Beijer, Barbro, Brings, Sebastian, Haberkorn, Uwe, Larbig, Gregor, Kübelbeck, Armin, Mier, Walter

“…Kidney-specific drug targeting is an attractive strategy to reduce unwanted side effects and to enhance drug efficacy within the renal tissue. For this purpose…”
Get full text

Drug Conjugation Affects Pharmacokinetics and Specificity of Kidney-Targeted Peptide Carriers by Janzer, Maria, Larbig, Gregor, Kübelbeck, Armin, Wischnjow, Artjom, Haberkorn, Uwe, Mier, Walter

“…Peptides play a crucial role as biological vectors for targeted drug delivery. In particular, in cases of specific receptor expression, peptides are highly…”
Get full text

Phenylthiazolyl-Hydrazide and Its Derivatives Are Potent Inhibitors of τ Aggregation and Toxicity in Vitro and in Cells by Pickhardt, Marcus, Larbig, Gregor, Khlistunova, Inna, Coksezen, Atilla, Meyer, Bernd, Mandelkow, Eva-Maria, Schmidt, Boris, Mandelkow, Eckhard

“…One of the key pathological features of Alzheimer's disease is the aggregation of tau protein. We are therefore searching for compounds capable of inhibiting…”
Get full text

Short and Diverse Route Toward Complex Natural Product-Like Macrocycles by Beck, Barbara, Larbig, Gregor, Mejat, Beatrice, Magnin-Lachaux, Marina, Picard, Anne, Herdtweck, Eberhardt, Dömling, Alexander

“…A general strategy toward macrocyclic compounds using multicomponent reaction (MCR) chemistry, e.g., Passerini and Ugi variants, and ring-closing metathesis…”
Get full text

Towards erythropoietin mimicking small molecules by Dömling, Alexander, Beck, Barbara, Baumbach, William, Larbig, Gregor

“…Design, synthesis and preliminary biological activity of small molecular weight EPO agonists is reported. Small molecules potentially mimicking the hormone…”
Get full text

Inhibitors Designed for Presenilin 1 by Means of Aspartic Acid Activation. Preliminary Communication by Larbig, Gregor, Zall, Andrea, Schmidt, Boris

“…γ‐Secretase, a multiprotein aspartic protease crucial to Alzheimer's dementia, is not available for NMR experiments and has, so far, escaped crystallization. A…”
Get full text

Modulators and inhibitors of gamma- and beta-secretases by Schmidt, Boris, Baumann, Stefanie, Narlawar, Rajeshwar, Braun, Hannes A, Larbig, Gregor

“…Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as a potential cause. The beta- and…”
Get more information

P2-138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl-hydrazide or rhodanine core structures by Pickhardt, Marcus, Bulic, Bruno, Larbig, Gregor, Coksezen, Atilla, Biernat, Jacek, Khlistunova, Inna, Mandelkow, Eva-Maria, Schmidt, Boris, Waldmann, Herbert, Meyer, Bernd, Mandelkow, Eckhard

Get full text

Synthesis of Tetramic and Tetronic Acids as β-Secretase Inhibitors by Larbig, Gregor, Schmidt, Boris

“…The aspartic protease β-secretase (BACE-1) is an attractive target for the therapy of Alzheimer's disease. The known inhibitors share a high analogy to the…”
Get full text

Book Review: Classics in Total Synthesis II: More Targets, Strategies, Methods.By K.C. Nicolaou and S.A. Snyder by Schmidt, Boris, Larbig, Gregor

Get full text