Search Results - "Larbi, K. Y."

MRL/lpr lupus‐prone mice show exaggerated ICAM‐1‐dependent leucocyte adhesion and transendothelial migration in response to TNF‐α by Marshall, D., Dangerfield, J. P., Bhatia, V. K., Larbi, K. Y., Nourshargh, S., Haskard, D. O.

“…Objective. Endothelial activation and dysfunctional leucocyte–endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus…”
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VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration by Larbi, Karen Y., Allen, Andrew R., Tam, Frederick W.K., Haskard, Dorian O., Lobb, Roy R., Silva, Patricia M.R., Nourshargh, Sussan

“…Eosinophil accumulation has been associated with the pathogenesis of numerous allergic inflammatory disorders. Despite the great interest in this response,…”
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Platelet-endothelial cell adhesion molecule-1 (PECAM-1)–deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane by Thompson, Richard D., Noble, Karen E., Larbi, Karen Y., Dewar, Ann, Duncan, Gordon S., Mak, Tak W., Nourshargh, Sussan

“…Studies with neutralizing antibodies have indicated roles for platelet-endothelial cell adhesion molecule-1 (PECAM-1) in leukocyte migration through the…”
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Complex pattern of inhibition by Mg2+ of exocytosis from permeabilised eosinophils by Larbi, K Y, Gomperts, B D

“…Inhibition by Mg2+ ions of exocytotic secretion from permeabilised eosinophils, stimulated by Ca2+ and GTP gamma S, and in the presence and absence of ATP, has…”
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Practical considerations regarding the use of streptolysin-O as a permeabilising agent for cells in the investigation of exocytosis by Larbi, K Y, Gomperts, B D

“…Streptolysin-O is widely used in cell biological investigations in order to make large (>12 nm) pores in the plasma membrane and so to render the cytosol…”
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Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation by McMillan, Sarah J, Kearley, Jennifer, Campbell, J. Darren, Zhu, Xing-Wu, Larbi, Karen Y, Shipley, J. Michael, Senior, Robert M, Nourshargh, Sussan, Lloyd, Clare M

“…Matrix metalloproteinases (MMPs) are a large family of endopeptidases that proteolytically degrade extracellular matrix. Many different cells produce MMP-9,…”
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MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-[alpha] by Marshall, D, Dangerfield, J P, Bhatia, V K, Larbi, K Y, Nourshargh, S, Haskard, D O

“…Objective. Endothelial activation and dysfunctional leucocyte-endothelial interactions are thought to play key roles in the pathogenesis of systemic lupus…”
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Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In Vivo by Young, Rebecca E, Thompson, Richard D, Larbi, Karen Y, La, Mylinh, Roberts, Clare E, Shapiro, Steven D, Perretti, Mauro, Nourshargh, Sussan

“…Neutrophil elastase (NE) remains a controversial player in the process of leukocyte transmigration and much of this controversy stems from conflicting reports…”
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Migration of leukocytes through the vessel wall and beyond by Yadav, Rashmi, Larbi, Karen Y, Young, Rebecca E, Nourshargh, Sussan

“…The migration of leukocytes from the vascular lumen to sites of infection and/or injury in the extravascular tissue involves a series of sequential and…”
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Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo by Thompson, R D, Wakelin, M W, Larbi, K Y, Dewar, A, Asimakopoulos, G, Horton, M A, Nakada, M T, Nourshargh, S

“…The final stage in the migration of leukocytes to sites of inflammation involves movement of leukocytes through the endothelial cell layer and the perivascular…”
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Thirty years of stimulus-secretion coupling: from Ca(2+) toGTP in the regulation of exocytosis by Pinxteren, J A, O'Sullivan, A J, Larbi, K Y, Tatham, P E, Gomperts, B D

“…Calcium, initially considered as the universal link between receptor stimulation and the onset of exocytosis in secretory cells, is now recognised as only one…”
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PECAM-1 (CD31) Homophilic Interaction Up-Regulates alpha sub(6) beta sub(1) on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of alpha sub(6) Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane by Dangerfield, J, Larbi, KY, Huang, M-T, Dewar, A, Nourshargh, S

“…Platelet-endothelial cell adhesion molecule (PECAM)-1 has been implicated in leukocyte migration through the perivascular basement membrane (PBM) though the…”
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P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses by Larbi, Karen Y., Dangerfield, John P., Culley, Fiona J., Marshall, Diane, Haskard, Dorian O., Jose, Peter J., Williams, Timothy J., Nourshargh, Sussan

“…The study investigated the role of P‐selectin in the responses of eosinophil transmigration and eotaxin generation in vivo elicited by interleukin (IL)‐13, as…”
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Complex pattern of inhibition by Mg super(2+) of exocytosis from permeabilised eosinophils by Larbi, KY, Gomperts, B D

“…Inhibition by Mg super(2+) ions of exocytotic secretion from permeabilised eosinophils, stimulated by Ca super(2+) and GTP gamma S, and in the presence and…”
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Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and beta sub(3) Integrin Blockade on Leukocyte Transmigration In Vivo by Thompson, R D, Wakelin, M W, Larbi, KY, Dewar, A, Asimakopoulos, G, Horton, MA, Nakada, M T, Nourshargh, S

“…The final stage in the migration of leukocytes to sites of inflammation involves movement of leukocytes through the endothelial cell layer and the perivascular…”
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